Objective:To research the therapeutic effect of Huayu Tonglin Recipe in treating chronic prostatitis. Method: A randomized controlled trial was carried out. Seventy one patients with chronic prostatitis were separated into two groups. Treatment group (41 cases) was treated with Huayu Tonglin Recipe, control group (30 cases) with Qianlieanshuan,a patent traditional Chinese drug and Norfloxacin. The treatment course was 1 month. The clinical effects of these two groups were compared and analysed. Result: After 1 month of treatment, 2 cases (4.9%) were completely cured, remarkable effective in 8 cases,(19.5%), and improved in 24 cases (58.5%) in treatment group, the effective rate was 82.9%; in control group, 1 case (3.3%) was completely cured, remarkable effective in 5 cases (16.7%), and improved in 14 cases (46.7%), the total effective rate was 66.7%. The total effective rate showed significant difference between these two groups (P<0.05). Conclusion: Huayu Tonglin Recipe is an effective recipe for chronic prostatitis.