Objective To investigate the clinical effect of Huagan Decoction combined with lansoprazole in the treatment of refractory gastroesophageal reflux disease (GERD). Methods A total of 66 patients with refractory GERD were randomly divided into treatment group and control group, with 33 patients in each group. The patients in the control group were given oral lansoprazole, and those in the treatment group were given oral Huagan Decoction in addition to the treatment in the control group. The two groups were observed in terms of traditional Chinese medicine (TCM) syndrome score and Gastroesophageal Reflux Disease Questionnaire (GERD-Q) score before treatment and after 4 weeks of treatment, and clinical outcome was compared between the two groups. Results Both groups had significant reductions in TCM syndrome score and GERD-Q score after treatment (P<0.05), and the treatment group had significantly greater reductions than the control group (P<0.05). There was a significant difference in the treatment outcome of TCM syndrome between the two groups (P<0.05). Conclusion Huagan Decoction combined with lansoprazole has a good clinical effect in the treatment of refractory GERD, with few adverse events.