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Sudden Death Secondary to an Undiagnosed B‐Cell Lymphoma of the Hypopharynx and Infiltration of the Inferior Constrictor Muscle
Authors:Sara Lo Pinto MD  Rosario Barranco MD  Maria Cuccì MD  Fiorella Caputo MD  Francesca Fossati MD  Giulio Fraternali Orcioni MD  Francesco Ventura MD  PhD
Affiliation:1. Department of Legal and Forensic Medicine, University of Genova, Genova, Italy;2. Department of Clinical Pathology, San Martino Hospital, Genova, Italy
Abstract:The aim of this presentation was to share an uncommon form of sudden death, suffered by a 64‐year‐old woman, due to a mechanical obstruction of hypopharynx by an undiagnosed B‐cell lymphoma, infiltrating the inferior pharyngeal constrictor muscle. A forensic approach by means of scene investigation, circumstantial data collection, autopsy, and histological and toxicological investigations led to conclude that the cause of death was asphyxia, correlated with B‐cell lymphoma of the hypopharynx. The autopsy examination highlighted the presence of a wall thickening, infiltrating, and projecting into the hypopharynx lumen. The histological analysis showed the essential finding of a B‐cell lymphoma of the hypopharynx, diffusely infiltrating the inferior pharyngeal constrictor muscle. To conclude, this case demonstrates once more that in the absence of specific data, a thorough forensic investigation including autopsy, histological examination, and circumstantial data collection is mandatory to reach a correct cause of death.
Keywords:forensic science  B‐cell lymphoma  hypopharynx  inferior constrictor muscle  asphyxia  sudden death
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