How to confirm C.E.R.A. doping in athletes' blood?

C.E.R.A. (Continuous Erythropoietin Receptor Activator) is a new third-generation erythropoiesis-stimulating agent that has recently been linked with abuse in endurance sports. The anti-doping community rapidly reacted by releasing a high-throughput screening ELISA allowing the detection of C.E.R.A. doping in athletes' blood. In order to return adverse analytical findings, anti-doping laboratories, however, need, as far as possible, to confirm the presence of the drug in athletes' samples through orthogonal methods. This article focuses on the comparison of 2 proposed confirmation assays based on gel electrophoresis that were coupled with a new sample immunopurification method. IEF, the classical method used to target erythropoietin (EPO) and its recombinant analogues in athletes' samples, and SARKOSYL-PAGE were applied to the plasma samples of subjects having received a single injection of C.E.R.A. It was demonstrated that SARKOSYL-PAGE was at least 6 times more sensitive than IEF, with comparable specificity. A longer detection window coupled with easier interpretation criteria led us to recommend the use of SARKOSYL-PAGE to confirm C.E.R.A. presence in athletes' blood.     

Doctors in the executive suite: should the U.S. and U.K. be putting M.D. licensure at risk for shortfalls in institutional quality of care?

As our healthcare system becomes further managed, delivery organizations are reincreasingly relying upon physician executives to administer the delivery of care by other individual providers. In both the United States and the United Kingdom, this has led to instances in which physician disciplinary procedures have been invoked with respect to physicians who are perceived to be responsible for institutional defiiciencies. The author examines and analyzes the contrasting approaches taken in the two countries, and recommends an activist approach for disciplinary agencies faced with these circumstances.     

Why Information? Choosing Committee Informativeness in U.S. State Legislatures

Using a new dataset drawn from American state legislatures, I modeled the informativeness of legislative committees as a choice over institutions. I found higher informativeness to be associated with better preparedness for information transfer, morepartisan chambers, and higher demand for information combined with greater incentives to control committee assignments. These associations shed light on congressional committee informativeness. A simple model of committee informativeness can predict the informativeness of the U.S. House's committees.     

Beyond the census. Reconstructing Dutch women's labour market participation in agriculture in the Netherlands,ca. 1830–1910

Many historians have pointed out for various countries that nineteenth-century national censuses do not accurately reflect women's economic activity. This was no different for the Dutch national censuses. In this article, we argue that under-recording was especially severe in agriculture, and that this problem increased towards the end of the century. The rise in under-recording was partly due to an increased irregularity of women's work on farms, but it also reflected changing living standards and ideologies, in which work was increasingly defined as undesirable for women. In relative terms, agriculture did become less important to men and women alike because of mechanization and industrialization. Nevertheless, agriculture continued to employ many women, especially married women and daughters working on their husbands' and fathers' farms. By offering additional source material and methods for estimating women's labour force participation in agriculture on a regional level, such as relating their occupational status to their husbands', and estimating the number of days worked, we aim to offer an enhanced methodology for gauging the work of women in agriculture, which may be applied to future research.     

Dr. Death? Professionalism,Virtue, and U.S. Physician Participation in the Death Penalty

In the United States at present, the death penalty is a possible sentence in 31 out of 50 states, as well as within the military and for federal cases. In the U.S., numbers of executions are declining, in part due to moratoriums in place and challenges to execution by lethal injection. Participation by physicians in lethal injection executions has been steadfastly viewed by professional medical organizations as contrary to their ethical standards. However, physicians have participated in lethal injection executions, and the morality of the death penalty itself is a matter of intense social and political debate. Medical ethics commentators and professional organizations have typically held that the prohibition on physician participation in the death penalty is independent of the ethical status of the death penalty itself. This article argues that this view is untenable, and that it is tied to a view of professional role virtue that is similarly untenable. At the same time, it argues that, given the morally uncertain status of the death penalty, it is plausible that virtuous physicians may either refuse or choose to participate in some aspects of the death penalty.     

Child Outcomes and Risk Factors in U.S. Homicide-Suicide Cases 1999–2004

Intimate partner homicide-suicide (IPHS) represents the most severe form of domestic violence, and often results in multiple fatalities. This paper examines outcomes of children in households that experience IPHS. Reports of 325 IPHS cases among adults age 18–44 in the U.S. between 1999 and 2004 were collected and examined. Results indicate children were often fatally wounded, but were most likely to witness the eventthen be absent or killed. Difficult financial conditions during times of economic downturn may increase the possibility of stress-related suicide, and subsequent familicide. Children with a suicidal parent are at increased risk of harm, so identification is of vital importance. Children are most likely harmed or killed by a primarily suicidal male perpetrator, who is usually their biological father. Firearms were used more than other methods in IPHS events. Even those perpetrators with protective orders more often utilized a firearm, which reflected a weakness in Violence Against Women Act gun ban enforcement. In this research, regions of the U.S. with less stringent firearm regulations were disproportionately likely to contain IPHS events. Findings illustrate the importance of making distinctions among perpetrators of IPHS, and assessing firearms policies, in order to improve child death prevention efforts.     

Felony Forfeiture in England,c.1170–1870

For much of English history, offenders punishable with death also forfeited their possessions. This article offers an overview of this long overlooked practice, demonstrating its continuation through to 1870, describing its contours, and charting how and why it changed over time. Intended primarily as a platform for future work, it also elucidates the history of the felony concept. Furthermore, forfeiture – the original, defining feature of felony – was all about property. Thus, the article also suggests that as long as forfeiture survived, the criminal law was shaped by the changing nature of ‘property’ itself.     

An agenda for change in U.S. climate policies? Presidential ambitions and congressional powers

The U.S. membership in the Asia-Pacific Partnership on Clean Development and Climate (APP) constituted an important element in the Bush administration’s voluntary and non-committing ‘soft-law’ approach to climate change. With the inauguration of President Barack Obama, the U.S. has embarked on a shift in its climate policy towards a legislative, ‘hard-law’ strategy. Obama’s approach implies that the distribution of interests in Congress becomes more significant. In this article, we assess the rules and procedures governing the relationship between the president and the Congress embedded in the U.S. Constitution and explore implications of a stronger congressional involvement in U.S. climate policies for President Obama’s ability to realise his climate policy ambitions at both the domestic and the international levels. We argue that the strong relationship between natural resource dependence (coal and oil) and opposition to climate policies is a constant feature of the U.S. climate policy debate. In order to succeed, Obama must break the enduring gridlock characterising congressional debate in this policy area by designing policies that, through compromise and compensation, can mobilise the support of oil- and coal-state representatives in Congress. The acceptability of an international climate treaty in Congress, moreover, depends inter alia on the resolution of the difficult issue of developing country participation. Success may be enhanced by using the APP and the Major Economies Initiative as informal arenas for negotiation and sector-based cooperation, thus providing a much-needed supplement to the UN-based negotiation process.

Is Timing Everything? Retirement and Seat Maintenance in the U.S. House of Representatives

Literature on open‐seat elections has focused on the individual attributes of a candidate and/or institutional arrangements. When a seat becomes an open contest could be a significant indicator as to how likely the incumbent party is able to maintain the seat. Examining data on open U.S. House seats from 1996 to 2008, we use OLS regression and logistic regression analysis, finding that time is a significant predictor for incumbent party fund‐raising and seat maintenance. We conclude that political parties have an interest in encouraging members of Congress to announce their retirement early in the election cycle.     

“Membership in a Particular Social Group”: International Journalists and U. S. Asylum Law

At least thirty non-U.S. journalists in the last decade have argued in U.S. Courts of Appeal that U.S. immigration authorities erroneously denied their asylum applications based on persecution in their native countries. However, only about 20% of journalists were successful, mirroring the approximate national asylum success rate for all applicants. The U.S. Immigration and Nationality Act does not include journalism as a basis for asylum, but some circuit court judges have stated that reporting on systemic official corruption is inherently political and, as a result could be grounds for asylum for persecuted journalists. A 2007 opinion from the U.S. Board of Immigration Appeals defining “particular social group,” a key requirement for asylum, is examined for its application to journalists.     

Shortcomings in the Operation and Coordination of Witness Protection in Australia. Where to from Here?

Criminal Law Forum - Witness protection in Australia has, to date, been less than successful in implementation and execution. An ad hoc system of Commonwealth and state/territory witness protection...     

Lost in registration? Missing occupations of single women in the Bruges countryside,c.1814

The absence of occupational titles for women in historical censuses has stymied numerous scholars. Various authors have explained this phenomenon as carelessness or bias on the part of the census-takers. Women's work was of little interest to the authorities and census officials focused their efforts upon the activities of the head of household. While source triangulation can be a useful tool for uncovering ‘hidden’ employment of women, it is often a complex and time-consuming process. In this article we outline an alternative to deal with the issue of missing occupations of single women in censuses by exploring their living arrangements. We identify four aspects of co-residence that can highlight the roles played within the household by single women without registered employment: their relation to the head of the household, and that individual's occupation, property and marital status. Comparing data from the 1814 population census regarding two social agro-systems and the city of Bruges, we argue that occupational titles of single women were not randomly omitted by the census officials, but reflect the embeddedness of these women in the family economy and household. While we do not refute recent research that stresses single women's economic independence during the long eighteenth century, our findings suggest that for a subset of singles this was not the case. We claim that by studying registered labour only, the historical picture of single women's work is biased or at the very least incomplete.     

C.S.I.全攻略

“到现场去”不仅仅是新闻格言在新闻报道中有这样一句名言：“到现场去。”说的是新闻记者只有到了新闻现场，才能更好地把握事实。这句话对于司法调查人员来说具有同样重要的意义，因为犯罪现场往往都留有揭开案件真相的线索。法庭科学的先驱性人物埃德蒙德·洛卡德曾经提出过著名的证据交叉原理：每一次接触总会带走一些东西，留下一些东西。也就是说，一个犯罪行为发生后，犯罪分子总会在犯罪现场留下蛛丝马迹。侦破人员只要循着这些蛛丝马迹，必定可以找到犯罪分子。洛卡德的这个格言意味着所有案件在理论上都是可以侦破的，真正的超完…     

What’s in a Name? Organizational,Environmental, and Cultural Factors on Support for Community Policing in Turkey and the U.S.

Community policing (COP) represents officers’ expectations of police work that revolves around specific order maintenance chores that take place within the community. It is generally assumed that police officers are cognizant of the community policing type activities occurring in police organizations where COP is either formally or informally adopted. However, very little research has been done to examine whether or not police officers in other countries are engaging in similar COP type activities without the organizational endorsement or official implementation of community policing as it is known in the U.S. and elsewhere. The aim of this paper is twofold. First, we compare law enforcement officers’ attitudes toward their conceptions of police work with specific attention to order maintenance and community oriented type police activities in two countries, Turkey (no formal COP programs) and the U.S. (formal and informal COP programs). Secondly, we examine to what extent police organizational and environmental factors in these two countries influence officers’ conceptions of community-oriented policing activities. Findings suggest that, relative to Turkey, U.S. police officers have a favorable disposition toward COP type activities, suggesting name does matter. However, findings in both countries also suggest that officers’ orientation to police work that is reflective of the police operational philosophy, and the organizational and environmental factors are better predictors of COP type activities.     

Parenthood in Murder‐Suicide News. Idealized Fathers and Murderous Mums

In this article I analyse how parents' lethal violence is presented in Finnish murder‐suicide news reports. I explore how gendered ideas of parenthood and violence affect these constructions. The cases that I am interested in are those with child victims where the perpetrator is either the father or the mother. The theoretical frame of analysis is feminist ethnomethodology, and Membership Categorization Analysis is used as the method. One of the starting‐points is that parenthood is gendered in a way that mothers and fathers have different rights, responsibilities and competences in our culture. In other words, moral orders of fathering and mothering exist. Because of this, women's and men's violent actions towards their own children are understood differently. When a man kills his children and himself he can be portrayed as a caring parent. Instead, in a certain context a woman can be ‘a killer mum’, her act ‘a murder’ and her personality described in the light of the deed. The focus of this article is on gender and family categorization used in murder‐suicide news in Finnish newspapers and the moral orders created in them. I explore the differences by mainly using two case examples: 1) a man who killed his three children and himself, and 2) a woman who killed her husband, two children and herself. The consequences of these newspaper constructions are also considered.     

Measuring Reed’s Reach: Content Discrimination in the U.S. Circuit Courts of Appeals After Reed v. Town of Gilbert

Commentators and justices on the Supreme Court of the United States speculated when the Court delivered its opinion in Reed v. Town of Gilbert in 2015 that the case would dramatically reshape First Amendment law. This article analyzes Reed’s impact to date in the United States Circuit Courts of Appeals. The article demonstrates that, although Reed has been consequential in some circuits, it has not been the basis of any First Amendment revolution. Indeed, the research supports the conclusion that many circuit courts seem to be actively working to narrow Reed’s reach. Moreover, the article concludes that Reed did little to clarify — and in some ways made worse — what has been a problematic doctrine for decades.