艾灸对腹泻型肠易激综合征模型大鼠海马与结肠组织中IKKβ/IKBα/NF-κB通路的影响

目的观察艾灸对腹泻型肠易激综合征(diarrhea predominant irritable bowel syndrome,IBS-D)模型大鼠海马与结肠组织中核因子κB抑制蛋白(inhibitor of nuclear factor kappa B,IκB)激酶β(IκB kinase beta,IKKβ)、核因子κB抑制蛋白α(NF-kappa-B inhibitor alpha,IKBα)、核因子κB(nuclear factor kappa B,NF-κB)(P65)相对表达水平的影响,探讨艾灸治疗IBS-D的机制。方法将24只健康雄性SD大鼠随机分为空白组、模型组和艾灸组,每组8只。采用慢性束缚联合番泻叶灌胃方法建立IBS-D大鼠模型。艾灸组予以艾灸"天枢""上巨虚",每日30min,每日1次,共治疗7d。治疗后,观察大鼠稀便率和直肠扩张所引起腹部回缩反射(abdominal withdrawal reflex,AWR)的最小容量阈值;蛋白质印迹法检测海马和结肠组织中IKKβ、IKBα、NF-κB(P65)蛋白表达水平。结果与空白组比较,模型组AWR的最小容量阈值明显下降(P<0.05),稀便率明显升高(P<0.05);海马和结肠组织中IKKβ、IKBα、NF-κB(P65)蛋白表达水平明显增加(P<0.05)。与模型组比较,艾灸组AWR的最小容量阈值明显升高(P<0.05),稀便率明显下降(P<0.05);海马和结肠组织中IKKβ、IKBα、NF-κB(P65)蛋白表达水平显著降低(P<0.05)。结论艾灸"天枢""上巨虚"改善IBS-D大鼠腹泻症状和内脏高敏感性可能与艾灸抑制海马与结肠组织IKKβ/IKBα/NF-κB信号通路有关,且其作用机制可能是通过脑-肠轴途径实现的。     

领导干部要积极预防和应对群体性事件

改革开放30余年的历史经验告诉我们,在中国不改革就不会有任何出路.当前要继续深化经济体制和政治体制改革.在大的改革时期,正是不同类型的群体性事件高发的时期,随着改革的深入发展如处理不好社会风险因素,往往易诱发群体性事件.目前各级地方政府及一些领导干部对于群体性事件的治理更多的是被动应对.因此,提升领导干部预防和应对群体性事件能力就显得十分迫切     

Still Golden British PM's China tour enhances Sino--British ties in the new era

正British Prime Minister Theresa May arrived on her maiden trip to China as the head of the British Government on January 31.Owing to numerous uncertainties at home including ongoing Brexit negotiations,terrorist attacks,a general election and a cabinet reshuffle,the highly anticipated visit had been postponed for almost a year.Nevertheless,the visit has been successful,evidenced by plentiful consensus     

近期中越海上问题与中越关系简析

近年来，中越两国在南海问题上时而出现一些摩擦，中越关系因为这些摩擦一直在曲折中保持发展，集中体现为双方高层间保持交流与互动。同时，中越双方还达成一系列共识，从大局和战略高度出发，推进双方全面战略合作伙伴关系，双方还愿妥善处理海上问题，维护南海和平与稳定。尽管中越双方已达成诸多原则共识，但越方在落实海上问题原则共识上需表现出更多诚意。     

Reflections on China＇s Periphery Strategy

Over the past few years, along with the changing situation in China＇s periphery, regional mechanisms and forums have been consolidating.     

新加坡汇率状况研究:2001～2011年

2001～2011年期间,新加坡汇率状况呈现为稳定、缓慢升值的态势,促进了新加坡经济的稳健发展。新加坡汇率的稳定走势,则是由新加坡合理的汇率制度安排和良好的政策配套决定的。     

Building a Safer Future

<正>Asian meeting on security finds synergy in Belt and Road In the past three decades,Asia was the most dynamic region in the world for economic growth with the emergence of a handful of emerging economies.It is home to more than two thirds of the world’s population and accounts for one third of the global economy.But     

Transcending Culture and Structure:Theoretical Paradigms of Cultural Sociology and Its Integration

Sociological theory which is dominated by structuralism paradigm faced with a series of crisis and predicament, and has given rise to a turn of cultural. It reviews and reflects critically the concept, development context and theoretical paradigms change of cultural sociology about domestic and foreign helps to gain insight into concerns and explanatory power of cultural sociology responding China’s current social issues. This article summarizes theoretical context of cultural sociology and its three leading research paradigms (culture-structuralism paradigm, stratification-class perspective, and strong-weak cultural program), and find that although the three paradigms have their own critically advantages, but faced with the common problem that is hard to jump out of the duality between culture and structure. Besides, this article tries to put forward an integrated research paradigm of cultural sociology, and in order to respond to the China’s indigenization of sociology and current social real issues.     

浅议“蒙面证人”制度

“蒙面证人”制度是一种隐匿证人身份或声音等形式的作证方式，主要目的是保护证人的人身安全。我国刑事诉讼法第六十二条规定的证人保护制度中就包含了“蒙面证人”制度的内容，这一证人保护制度与保障被告人对质权具有刑事诉讼法价值取向上的冲突，在厘清二者关系的同时探寻一条完善我国刑事证人出庭制度的新路径应当是解决我国刑事案件证人出庭问题的应然选择。     

社会管理模式检讨与“适切”原则——基于当代中国社会结构的亚稳态现状

三十多年的改革开放和社会发展使中国社会结构、社会特征发生了深刻变化,社会基本态势已从稳定态向亚稳定态转变.传统社会管理模式的粗放、被动、无序、低效、线性、一维等方法已经远不能适应社会结构的变化.基于“适切”原则的社会管理模式应在社会信仰、协商机制、基层建设、问责制度和网络舆情等方面进行全面转型和创新.