Loss of CD103~+ intestinal dendritic cells during colonic inflammation

AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived fro...     

Criminal superstition, pregnancy and infants at the turn of the 19th century

Around 1900, various crimes were still caused by criminal superstition. Criminologists like Hans Gross, Albert Hellwig and August L?wenstimm were engaged in the exploration of this topic aiming at the complete explanation of criminal behaviour linked to superstition. Crimes against pregnant women and infants are particularly good examples to illustrate the problems arising from crimes motivated by superstition. When assessing superstition under scientific and legal aspects, the criminologists applied different approaches, although positivistic rationalization was the most common tendency. In the forensic and legal evaluation of crimes related to superstition the problematical questions were whether the perpetrator was criminally responsible and how the offence was to be legally qualified. In many cases, criminals motivated by superstition were treated with more lenience.     

Commercialisation of regenerative human tissue: regulation and reform in Australia and England, Wales and Northern Ireland

The commercialisation of therapeutic products containing regenerative human tissue is regulated by the common law, statute and ethical guidelines in Australia and England, Wales and Northern Ireland. This article examines the regulatory regimes in these jurisdictions and considers whether reform is required to both support scientific research and ensure conformity with modern social views on medical research and the use of human tissue. The authors consider the crucial role of informed consent in striking the balance between the interests of researchers and the interests of the public.     

China–Africa Cooperation: promises,practice and prospects

Chinese engagement in African states has increased tremendously over the last decade, much in line with Chinese globalisation strategies and supported by state encouragement and financial support. The size and potential of China as a world power leads to the level of expectations the country faces from the developing world. However, some elements of these expectations are also created through political discourses which emphasise differences with Western countries. The types of promises that the Chinese leadership makes to create such enthusiastic welcome amongst African political leaders are linked closely to the discourse on South–South cooperation. Albeit different from Western development assistance promises and parallel attempts to produce moderate expectations, the current discourse is thus partly sowing the seeds for future disappointment. This article takes a closer look at the discussions around South–South cooperation in China–Africa relations and at key rhetorical features (‘mutual benefit’; ‘non-interference’) and at the practice of this cooperation. It concludes that the Chinese discourse is creating large public expectations in African countries and while China delivers on many projects, its impact on development is less certain. The overall development success of this strategy builds on longer-term success and is implicitly linked to the occurrence of more reforms in Africa. Chinese policy thus ‘bets on the future’ in their foreign relations with Africa; the success of this strategy is dependent on political circumstances among the partners that are largely beyond Chinese control. In a number of cases, it can thus be expected that currently up-beat political rhetoric is going to meet obstacles that will require adjustments in a discourse that, in its current form, might undermine Chinese credibility if not the core elements of South–South cooperation altogether.     

L'effet des rapports financiers sur la dynamique fédérale: la qualité médiative du fédéralisme suisse

The article examines the horizontal and vertical fiscal relations as explanatory factors of the interaction dynamics between levels of government in Switzerland. It presents the intergovernmental financial relations in Switzerland, comparing them to those in other federal countries and outlining the current reforms of the equalization system and the distribution of tasks. The author analyzes the effect the fiscal relations have on the intergovernmental interaction dynamics and discusses the potential implications of the current reforms for Swiss federalism. She demonstrates that the interaction dynamics that result from the financial relations are characterized by compensation, multilevel coordination and more rarely by unilateralism. The transformation of the financial relations that result from the current reforms, in particular the weakening of existing coordination structures, may lead to increased unilateralism and thus reduce the mediative capacity of Swiss federalism. Yet, the reform process also shows how durable the complex coordination structures are, which should be eliminated by the reforms.     

„Selbstbewusst“ und „stolz“. Das außenpolitische Vokabular der Berliner Republik als Fährte einer Neuorientierung

The article sketches a newly developed analytical approach (“vocabulary analysis”) inspired by philosophy of language. Without engaging in the debate as to whether Germany’s foreign policy is best characterised either in terms of continuity or change, the article reconstructs the development of the German foreign policy practice between 1986 and 2002 on the basis of the foreign policy elite’s discourse. In an exemplary fashion it illustrates the use of the key concepts Germany, Europe, power, responsibility, self-confidence and pride. We conclude that vocabulary analysis reveals astonishing shifts in the semantic web of which German foreign policy discourse is “woven” — shifts which will also leave traces in Germany’s foreign policy identity.     

Reimbursement schemes for hospitals, malpractice liability, and intrinsic motivation

We develop a simple multi-task principal-agent model to analyze the interplay between optimal reimbursement schemes for hospitals and liability rules (basic model). We then extend our model and assume that the hospital is intrinsically motivated to exert positive effort for quality and cost reduction. This effort, however, is biased towards quality. Moreover, the intrinsic motivation may be crowded out by monetary incentives. In such a setting, we find that a pure prospective payment system (PPS) that has become widespread in recent years can only be optimal in the unlikely case where malpractice liability holds hospitals fully responsible for expected harm. For other cases, we confirm the prejudice that PPS may lead to inefficiently low quality. Then, the traditional fee-for-service (FFS) system is superior if the intrinsic motivation is high and relatively little biased towards quality, whereas mixed systems should be chosen otherwise. Our model sheds light on why countries like the USA with a tough liability system haven been less reluctant to switch from FFS to PPS than Germany, for instance.