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This paper reviews and updates the conceptual approaches of the author's Journeys Towards Progress (1963). It focuses first on distinctions explaining differences in the path of policymaking and in its effectiveness. Distinctions are made between pressing and autonomously chosen policy problems, between privileged problems and neglected ones that must manage to “ride the coattails” of the former to receive attention, and between policy tasks that are tackled with more motivation than understanding and those with the opposite characteristic. Addressing then similarities in experience with policymaking, the paper first comments on fracasomania (the failure complex) and on the incapacity ever to be surprised at both consequences and determinants of under-development. Indirect and unanticipated effects of policies are illustrated through a Colombian example. A Concluding Lament suggests that the watch for side-effects must be unusually wide-angled in today's Latin America.  相似文献   
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This article looks at the effect that damage caps have on plaintiffs'recovery in medical malpractice litigation, using a unique dataset of litigation in the South, from 1987 to 1999. During thistime, Alabama underwent both the implementation and nullificationof damage-cap laws; neighboring states did not undergo any significantlegal changes. The product of a difference-in-difference approach,the results reveal that the average relative recovery by Alabamaplaintiffs decreased by roughly $20,000 after the Alabama legislatureenacted damage caps and increased by roughly double that amountafter the Alabama Supreme Court ruled them unconstitutional.  相似文献   
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Drug‐impaired driving is a complex area of forensic toxicology due in part to limited data concerning the type of drugs involved and the concentrations detected. This study analyzed toxicological findings in drivers from fatal motor vehicle collisions (FMVCs) in Ontario, Canada, over a one‐year period using a standardized protocol. Of the 229 cases included in the study, 56% were positive for alcohol and/or drugs. After alcohol, cannabis was the most frequently encountered substance (27%), followed by benzodiazepines (17%) and antidepressants (17%). There were differences in drugs detected by age but no marked difference in drugs detected between single and multiple FMVC's. Not all drugs detected were considered impairing either due to drug type, concentration or case history. The findings indicate the importance of comprehensive drug testing in FMVCs and highlight the need to consider a variety of factors, in addition to drug type and concentration, when assessing the role of drugs in driving impairment.  相似文献   
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Early interventions are a preferred method for addressing behavioral problems in high‐risk children, but often have only modest effects. Identifying sources of variation in intervention effects can suggest means to improve efficiency. One potential source of such variation is the genome. We conducted a genetic analysis of the Fast Track randomized control trial, a 10‐year‐long intervention to prevent high‐risk kindergarteners from developing adult externalizing problems including substance abuse and antisocial behavior. We tested whether variants of the glucocorticoid receptor gene NR3C1 were associated with differences in response to the Fast Track intervention. We found that in European‐American children, a variant of NR3C1 identified by the single‐nucleotide polymorphism rs10482672 was associated with increased risk for externalizing psychopathology in control group children and decreased risk for externalizing psychopathology in intervention group children. Variation in NR3C1 measured in this study was not associated with differential intervention response in African‐American children. We discuss implications for efforts to prevent externalizing problems in high‐risk children and for public policy in the genomic era.  相似文献   
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