Inter- and intra-subject variability in ethanol pharmacokinetic parameters: effects of testing interval and dose

Calculation of a blood alcohol concentration (BAC) at the time of an offence by forward or back-extrapolation, using population average values for ethanol pharmacokinetic parameters or a single estimate of individual specific parameters, ignores the possibility of inter- and intra-subject variability. In order to estimate inter- and intra-subject variability in the elimination rate and absorption rate, BAC was measured over time in 12 male volunteers on 4 occasions. Subjects received 0.44 g kg(-1) body weight of ethanol on the first study day, and 0.70 g kg(-1) body weight on subsequent study days 1, 11 and 12 weeks later, to enable comparisons in variability over short and long time periods and when the same or different doses were administered. Evidence of both inter- and intra-subject variability was found, with inter-subject variability substantially smaller than intra-subject variability when the dose varied. Forensically important differences in pharmacokinetic parameters were observed within individuals between occasions. These findings could have an important impact on medico-legal issues related to ethanol pharmacokinetics.     

Taking Fact-Checks Literally But Not Seriously? The Effects of Journalistic Fact-Checking on Factual Beliefs and Candidate Favorability

Political Behavior - Are citizens willing to accept journalistic fact-checks of misleading claims from candidates they support and to update their attitudes about those candidates? Previous studies...     

How to build a time machine for public affairs executives

Temporal factors such as time and timing are so self‐evident in public affairs that they are rarely mentioned and even less frequently researched. Time is seen as the independent variable—a scaffold that underpins a calendar of communication events, legislative and regulatory processes, or issue lifecycles. However, time is a more complex and essential variable to contemplate than public affairs (and most other) executives give it credit for. This paper explores 16 unique ways to think about time, applying those dimensions to the Amazon HQ2 (second headquarters) selection process to illustrate how public affairs executives could use them to illuminate aspects of strategy and behavior they might otherwise not consider. Strategically, understanding interconnected dimensions of time improves clarity in the choice‐making process, allowing public affairs executives to exploit ideal timing as they execute their strategies.     

An Exploratory Study of Emotional Intelligence and Domestic Abuse

To date, there is no literature specifically addressing the relationship between spousal battering and emotional intelligence, a concept that captures the success, or lack thereof, of a person's functioning in their immediate environment. Forty-four men convicted of spousal assault and 76 undergraduate students completed the Emotional Quotient Inventory (EQ-i; R. Bar-On, BarOn Emotional Quotient Inventory: User's Manual, Multi-Health Systems, Inc., Toronto, 1997), the Propensity for Abusiveness Scale (PAS; D. G. Dutton, J. Fam. Violence 10(2): 203–221, 1995), and the Balanced Inventory of Desirable Responding (D. Paulhus, J. Pers. Soc. Psychol. 46: 598–609, 1984; Assessing Self-Deception and Impression Management in Self-Reports: The Balanced Inventory of Desirable Responding, Unpublished manual, University of British Columbia, Vancouver, Canada, 1988; In Measures of Personality and Social Psychological Attitudes, Academic Press, San Diego, CA, pp. 17–59, 1991). Results of this exploratory study indicate that batterers score significantly lower than the general population on all components of EQ-i. Additionally EQ-i total and subscale scores for both samples correlate negatively and significantly with scores on PAS, suggesting that deficits in various components of emotional intelligence are related to an increase in the propensity to be abusive. Implications for batterer treatment are discussed.     

Tunnel vision: The regulation of endocrine disruptors

This study examines the failure of a small but significant element of U.S. chemical regulatory policy: the Endocrine Disruptor Screening Program (EDSP). A range of conditions are implicated in the failure of this program, but one condition, the scientific testing and regulation paradigm (STRP), seems particularly important and ties the failure of EDSP to the failure of other U.S. chemical regulatory programs. This paradigm is a group of assumptions that have driven pesticide (and other chemical) regulatory policy since World War II. This study investigates the relationship between STRP and the failure of EDSP, the potential efficacy of alternatives to this program, and one alternative that broke from this paradigm. Ultimately, this study suggests that we must revise the role of science in regulation in order to find effective alternatives to modern chemical regulatory policy.     

Extralegal factors and the sentencing of organizational defendants: An examination of the Federal Sentencing Guidelines

The Federal Sentencing Guidelines were developed to provide uniform and standardized punishments for eliminating sentence disparities based on legally irrelevant factors. While research at the individual level showed that extralegal factors continued to affect sentence outcomes, no such research determined if these factors influenced sentencing of organizational offenders. This article extends the unit of analysis beyond the individual and toward organizational offenders to determine if total fine amounts are affected by extralegal organizational characteristics. Relying on post-1991 organizational defendant's data, the findings indicated both legal and extralegal factors significantly affected fine outcomes for organizational offenders. As expected, several legal factors significantly affected fine outcomes. At least two extralegal variables, economically solvent and closely held organizations, however, exerted significant effects in predicting the total fine amount imposed. Similar to research at the individual level, this study indicated that extralegal or legally irrelevant factors had some level of impact upon sentencing under the guidelines.     

Parliament,printed petitions and the political imaginary in seventeenth-century England

ABSTRACT

Building on recent scholarship relating to the emergence of printed petitions in Britain in the seventeenth century, this article concentrates on those printed petitions that were designed for more or less discreet or limited circulation in order to lobby parliament. It draws on two collections of such material gathered by the MPs Bulstrode Whitelocke (in the 1650s) and Sir Michael Wentworth (in the 1680s and 1690s). Because print facilitated novel ways of engaging with parliament – not least as problems went unresolved and cases dragged on – printed petitions provide a useful window into the aspirations and frustrations of supplicants, and indeed into their political thinking, however rudimentary this may have been. In tracing what might be called the ‘political imaginary’ of contemporary petitioners, this study recovers evidence of radicalization, but also suggests that the art of petitioning could involve the deliberate avoidance of ideological issues that nevertheless underpinned specific interventions.     

John Howard's “Use” of the Anzac Legend: Applying an Epideictic Lens

While many have remarked upon Prime Minister John Howard's “use” of the Anzac legend for political purposes, our understanding of the nature and dynamics of such use remains fragmented and underdeveloped. Using the area of foreign policy as a case study, this essay approaches Howard's Anzac Day and related ceremonial rhetoric as examples of the epideictic genre, which presents speakers with a combination of unique rhetorical opportunities and strict generic constraints. While often perceived as apolitical and inconsequential, the genre embodies a form of argumentation that serves not only to increase the “intensity of adherence” to certain values, thus laying the groundwork for later deliberative appeals, but also creates a “disposition to act at the appropriate moment”. This paper will argue that Howard's employment of Anzac was bounded and defined by the nature and dynamics of the epideictic genre, of which Howard proved to be a savvy user.     

Political parties and political shirking

Using ADA roll call voting scores for the 1947–2006 period, I find that senators shirk in their last term. The degree of shirking is limited by political parties, which constrain the politician in his last term, and varies by post-Senate career choices. The results highlight the importance of political parties in the repeated game that is electoral politics.