Estimating Individual Contributions to Complex DNA SNP Mixtures.,

High‐throughput sequencing (HTS) of large panels of single nucleotide polymorphisms (SNPs) provides an alternative or complimentary approach to short tandem repeats (STRs) panels for the analysis of complex DNA mixture forensic samples. For STRs, methods to estimate individual contribution concentrations compare capillary electrophoresis peak heights, peak areas, or HTS allele read counts within a mixture. This article introduces three approaches (mean, median, and slope methods) for estimating individual DNA contributions to forensic mixtures for HTS/massively parallel sequencing (MPS) SNP panels. For SNPs, the major:minor allele ratios or counts, unique to each contributor, were compared to estimate contributor proportion within the mixture using the mean, median, and slope intercept for these alleles. The estimates for these three methods were typically within 5% of planned experimental contributions for defined mixtures.     

Public and elite opinion on international human rights law: Completing the causal chain of the domestic compliance mechanism

Why do states comply with international human rights law? Scholars have looked to domestic politics to suggest a constituency-driven domestic compliance mechanism. However, it is unclear if strong public support for compliance leads to greater willingness to comply among elected officials. This study is the first to empirically demonstrate the complete causal chain of a constituency-driven domestic compliance mechanism. Using a survey experiment, this study first finds that a strong state commitment to UN Norms on the Responsibilities of Transnational Corporations (RTNC) increases public support for compliance. Using a parallel lab-in-the-field experiment of sitting legislators, the study then finds that a strong state commitment to RTNC is similarly associated with increased elite support for compliance. Finally, the study finds that public demand for compliance is associated with even greater elite support for compliance. Public demand for compliance seems to elicit elite willingness to comply by raising reputational concerns.     

Hearts of Darkness: white women write race

Abstract

In an effort to popularise the gas stove, boost sales and minimize the genuine and perceived dangers of using this volatile domestic appliance, late Victorian gas managers and stove manufacturers employed female cookery teachers to perform public demonstrations at trade exhibitions throughout the country. Eventually, these women comprised a special department of gas sales, calling directly on customers in their homes to offer personal instruction in the proper use and care of gas stoves. Part social workers, part salesgirls, the ‘lady demons’, short for lady demonstrators, moved between the traditionally gendered separate spheres of work and home, consciously constructing a professional image that reconciled the social tensions of this new occupation. They offer an early example of women's entrance into the corporate business world, the feminisation of consumption, and the combination of customer service with social welfare.