A distinct Y-STR haplotype for Amelogenin negative males characterized by a large Y(p)11.2 (DYS458-MSY1-AMEL-Y) deletion

The use of STR multiplexes with the incorporated gender marker Amelogenin is common practice in forensic DNA analysis. However, when a known male sample shows a dropout of the Amelogenin Y-allele, the STR system falsely genotypes it as a female. To date, our laboratory has observed 18 such cases: 12 from our Y-STR database and six from casework. A study on 980 male individuals in the Malaysian population using the AmpFlSTR Y-filer has revealed a distinct Y-chromosome haplotype associated with the Amelogenin nulls. Our results showed that whilst the Amelogenin nulls were noticeably absent among the Chinese, both the Indians and Malays exhibited such mutations at 3.2 and 0.6%, respectively. It was also found that the Amelogenin negative individuals predominantly belonged to the J2e lineage, suggesting the possibility of a common ancestor for at least some of these chromosomes. The null frequencies showed concordance with the data published in Chang et al. [Higher failures of Amelogenin sex test in an Indian population group, J. Forensic Sci. 48 (2003) 1309-1313] on a smaller Malaysian population of 338 males which used a Y-STR triplex. In the current study, apart from the absence of the Amelogenin Y-locus, a complete absence of the DYS458 locus in all the nulls was also observed. This study together with the 2003 study has indicated a similar deletion region exists on the Y(p)11.2 band in all the 18 Y-chromosomes. Using bioinformatics, this deletion has been mapped to a region of at least 1.13 Mb on the Y(p)11.2 encompassing the Amelogenin, MSY1 minisatellite and DYS458 locus. Further, the Y-filer haplotypes revealed an additional null at Y-GATA H4 in two of the Indian males presented here.     

The “dictator’s endgame”: Explaining military behavior in nonviolent anti-incumbent mass protests

This article introduces a configurative theory to explain military reactions to nonviolent mass protests in dictatorships. An empirical analysis of three cases of such “dictators endgames” (Burma in 1988, Sudan in 1985, and East Germany in 1989), shows that militaries will defend the dictator against the masses if the military leadership’s physical and economic well-being is linked to the dictator’s survival in office. In turn, military leaders will defect from the regime incumbent only if the alternatives of siding with the opposition or staging a coup d’état is expected to be more beneficial to their interests than staying loyal to the regime.     

College education,major, or criminology classes? An examination of what drives students’ level of punitiveness

This study examines the level of punitiveness of criminology and criminal justice (CRIM) majors and non-majors. In particular, undergraduate students from a mid-western university situated in a rural area were surveyed to determine if college education, major, or exposure to CRIM classes impacts their punitive attitudes towards offenders. Regression analyses suggest that it is not the number of CRIM classes or the liberalization effect of college but the major that best predicts the level of punitiveness. Results also indicate that predictors of punitiveness differ between CRIM majors and non-CRIM majors. Implications of these findings are discussed.