Review: The physiology of saliva and transfer of drugs into saliva

Although saliva or oral fluid "lacks the drama of blood, the sincerity of sweat and the emotional appeal of tears", quoting Mandel in 1990 [I.D. Mandel, The diagnostic uses of saliva, J. Oral Pathol. Med. 19 (1990) 119-125], it is now meeting the demand for inexpensive, non-invasive and easy-to-use diagnostic aids for oral and systemic diseases, drug monitoring and detection of illicit use of drugs of abuse, including alcohol. As the salivary secretion is a reflex response controlled by both parasympathetic and sympathetic secretomotor nerves, it can be influenced by several stimuli. Moreover, patients taking medication which influences either the central nervous system or the peripheral nervous system, or medication which mimic the latter as a side effect, will have an altered salivary composition and salivary volume. Patients suffering from certain systemic diseases may present the same salivary alterations. The circadian rhythm determines both the volume of saliva that will and can be secreted and the salivary electrolyte concentrations. Dietary influences and the patient's age also have an impact on composition and volume of saliva. The latter implies a wide variation in composition both inter- and intra-individually. Sampling must therefore be performed under standardized conditions. The greatest advantage, when compared to blood sample collection, is that saliva is readily accessible and collectible. Consequently, it can be used in clinically difficult situations, such as in children, handicapped and anxious patients, where blood sampling could be a difficult act to perform.     

The ICTR Ten Years On: Back to the Nuremberg Paradigm?

Since his appointment in 2003, the Prosecutor of the InternationalCriminal Tribunal for Rwanda (ICTR) remains silent on the issueof prosecuting officials of the victorious Rwandan PatrioticFront (RPF). There is certainly no lack of credible reportsabout massive violations of human rights and international humanitarianlaw by the RPF both in Rwanda and in neighbouring countries,in 1994 and thereafter. The Prosecutor and the UN Security Council,despite lip service to the contrary, seem less than eager toconfront the government in Kigali. It is therefore to be fearedthat prosecutorial practice at the ICTR will follow the Nurembergparadigm. This one-sided policy may, however, have far-reachingconsequences.     

Identity Statuses Based on 4 Rather Than 2 Identity Dimensions: Extending and Refining Marcia's Paradigm

Four identity dimensions (Commitment Making, Identification with Commitment, Exploration in Depth, and Exploration in Breadth) were used to derive identity statuses by means of cluster analysis in a sample of late adolescents. This strategy resulted in both a qualitative refinement and a quantitative extension of Marcia's (1966) model. Five clusters were retained. Four of those (the Achievement, Moratorium, Foreclosure, and Diffused Diffusion Cluster) bore a striking resemblance to Marcia's original identity statuses in terms of their definition and their associations with criterion variables. Adolescents in the fifth cluster, the Carefree Diffusion Cluster (low to moderate on both commitment dimensions and low on both exploration dimensions), scored as high as the 2 high Commitment Making clusters (i.e., the Achievement and Foreclosure Cluster) on several indicators of adjustment. Personality characteristics further differentiated these clusters in accordance with theory. The advantages of expanding the identity status paradigm, through additional distinctions that pertain to both commitment and exploration, are discussed and practical implications are outlined. Doctoral Researcher for the Special Research Fund (B.O.F.)—Flanders (Belgium). Current research focuses on adolescent identity formation and development. Assistant Professor of Developmental Psychology, Catholic University Leuven, Belgium. Received PhD in developmental psychology from the Catholic University Leuven, Belgium, 1988. Current research interests include adolescent identity, autonomy, and loneliness. Doctoral Researcher for the Fund of Scientific Research (F.W.O.)—Flanders (Belgium) at the Catholic University Leuven, Belgium. Research interests include parent–adolescent relationships, identity processes, and acculturation orientations of ethnic minority members. Postdoctoral Researcher for the Fund of Scientific Research (F.W.O.)—Flanders (Belgium). Received PhD in developmental psychology from the Catholic University Leuven, Belgium, 2001. Current research focuses on adolescent autonomy, parenting and mediators of parenting effects on individuation and identity. Doctoral Researcher for the Fund of Scientific Research (F.W.O.)—Flanders (Belgium) at the Catholic University Leuven, Belgium. Research interests include motivational processes, self-determination theory, parent–adolescent relationships, and identity processes.     

Spatial Effects and Ecological Inference

This paper examines the role of spatial effects in ecologicalinference. Both formally and through simulation experiments,we consider the problems associated with ecological inferenceand cross-level inference methods in the presence of increasingdegrees of spatial autocorrelation. Past assessments of spatialautocorrelation in aggregate data analysis focused on unidimensional,one-directional processes that are not representative of thefull complexities caused by spatial autocorrelation. Our analysisis more complete and representative of true forms of spatialautocorrelation and pays particular attention to the specificationof spatial autocorrelation in models with random coefficientvariation. Our assessment focuses on the effects of this specificationon the bias and precision of parameter estimates.     

New Institutional Arrangements for Rural Development: The Case of Local Woolgrowers' Associations in the Transkei Area,South Africa

Until recently, smallholder farmers in the Transkei area had very limited access to a profitable market outlet for their wool. In response, the South African wool industry built shearing sheds, managed by a local association that sells directly to the brokers. This article investigates the effect of joint wool marketing through the shearing shed on the farmers' revenue from wool. A three-step regression model of the revenue from wool indicates that the farmers selling through the shearing shed obtain better financial results as compared to those who use alternative channels. This analysis shows how new institutional arrangements may contribute to economic development.     

Parental Depressive Feelings, Parental Support, and the Serotonin Transporter Gene as Predictors of Adolescent Depressive Feelings: A Latent Growth Curve Analysis

Parental support and parental depressive feelings are found to be associated with depressive feelings in adolescent boys and girls, but results are inconsistent. In addition, the 5-HTTLPR genotype has been found to interact with environmental stressors in predicting adolescents?? depressive feelings, but this has not been examined longitudinally. Therefore, the present study examined the relationships between parental support, parental depressive feelings, and adolescent depressive feelings. In addition, the relationships between the 5-HTTLPR genotype and adolescent depressive feelings were explored, as well as gene-environment interactions. Adolescents (N = 306; Girls = 53.3%; M _{age T1} = 13.4) filled out questionnaires at five annual waves and provided saliva samples for DNA. Latent growth curve modelling (LGCM) was used to examine the baseline level and the change in depressive feelings over time. Maternal support was related to baseline levels of depressive feelings in girls, whereas paternal support was related to baseline levels in boys. Paternal depressive feelings were only related to boys?? depressive feelings at baseline, and maternal depressive feelings were not related to any outcome measures. Furthermore, no associations were found between 5-HTTLPR genotype and adolescent depressive feelings, and no gene-environment interactions emerged. Limitations of the study and implications of the findings are discussed.     

On the use of IRMS in forensic science: proposals for a methodological approach

The flourishing number of publications on the use of isotope ratio mass spectrometry (IRMS) in forensic science denotes the enthusiasm and the attraction generated by this technology. IRMS has demonstrated its potential to distinguish chemically identical compounds coming from different sources. Despite the numerous applications of IRMS to a wide range of forensic materials, its implementation in a forensic framework is less straightforward than it appears. In addition, each laboratory has developed its own strategy of analysis on calibration, sequence design, standards utilisation and data treatment without a clear consensus. Through the experience acquired from research undertaken in different forensic fields, we propose a methodological framework of the whole process using IRMS methods. We emphasize the importance of considering isotopic results as part of a whole approach, when applying this technology to a particular forensic issue. The process is divided into six different steps, which should be considered for a thoughtful and relevant application. The dissection of this process into fundamental steps, further detailed, enables a better understanding of the essential, though not exhaustive, factors that have to be considered in order to obtain results of quality and sufficiently robust to proceed to retrospective analyses or interlaboratory comparisons.