Suicide by nitrous oxide poisoning

Fatal nitrous oxide poisoning usually occurs accidentally during the administration of general anesthesia. It seldom occurs during autoerotic behavior or in acute drug abuse. We report an unusual case of a health professional who committed suicide by inhaling nitrous oxide.     

Further evidence of the validity of the Suicide Risk Assessment Scale for prisoners

The Suicide Risk Assessment Scale (SRAS; nine items) is useful in correctional settings but needed further validation. First, 44 inmates originally screened as suicidal with the SRAS were evaluated by institutional psychologists according to five criteria: suicidal urgency, risk, appropriateness of referral, need for short- or long-term watch. On the whole, the SRAS was judged to be as effective as a more elaborate test. Second, 242 suicidal and non-suicidal inmates were tested with the SRAS. Their results correlated better with suicidal risk (.71) than with urgency (.50). Receiver operating characteristic (ROC) analysis even showed that the SRAS performed better than a more elaborate test in predicting risk.     

Can electronic monitoring reduce crime for moderate to high-risk offenders?

Electronic monitoring (EM) of offenders has been in use for just over two decades and motives for using it remain diverse. Some agencies that use EM attempt to deliver humane and affordable sanctions while others seek to relieve jail crowding or to avoid the construction of new jails. Nonetheless, all EM programs aim to suppress the criminal behavior of offenders being monitored and its advocates have always hoped EM could be instrumental in reducing long-term recidivism. This review investigates the history of EM and the extent to which EM empirically affects criminal behavior in moderate to high-risk populations. All available recidivism studies that included at least one comparison group between the first impact study in 1986 and 2002 were considered for the review. Although variants such as GPS tracking and continuous testing for alcohol in perspiration have recently emerged, no studies of these technologies were found that met the review’s inclusion criteria. Studies are examined and combined for meta-analysis where appropriate. Given its continued and widespread use and the dearth of reliable information about its effects, the authors conclude that applications of EM as a tool for reducing crime are not supported by existing data. Properly controlled experiments would be required to draw stronger conclusions about the effects of EM.     

The causal relationship between gang joining and violent victimization: A critical review and directions for future research

Purpose

This article provides a critical review of the state of research on the gang membership-violent victimization relationship.

Methods

This study examines a comprehensive list of published quantitative studies that have assessed the relationship between gang membership and violent victimization.

Results

By examining strengths and weaknesses of the design features of various studies, this article identifies theoretical, conceptual, methodological, and statistical issues that should be considered when interpreting the causal effect of gang membership on violent victimization. Some of the methodological and design issues discussed include, but are not limited to, consequences of failing to establish temporal order, failure to conduct sensitivity analyses to determine treatment effects, use of bootstrapping methods with propensity score analysis, measurement of violent victimization, and corrections for dependence in matched samples of gang and non-gang members.

Conclusion

Suggestions for future research are provided that will help advance the empirical study of the gang membership-violent victimization nexus.     

Fatal tolperisone poisoning: autopsy and toxicology findings in three suicide cases

Tolperisone (Mydocalm) is a centrally acting muscle relaxant with few sedative side effects that is used for the treatment of chronic pain conditions. We describe three cases of suicidal tolperisone poisoning in three healthy young subjects in the years 2006, 2008 and 2009. In all cases, macroscopic and microscopic autopsy findings did not reveal the cause of death. Systematic toxicological analysis (STA) including immunological tests, screening for volatile substances and blood, urine and gastric content screening by GC-MS and HPLC-DAD demonstrated the presence of tolperisone in all cases. In addition to tolperisone, only the analgesics paracetamol (acetaminophen), ibuprofen and naproxen could be detected. The blood ethanol concentrations were all lower than 0.10 g/kg. Tolperisone was extracted by liquid-liquid extraction using n-chlorobutane as the extraction solvent. The quantification was performed by GC-NPD analysis of blood, urine and gastric content. Tolperisone concentrations of 7.0 mg/l, 14 mg/l and 19 mg/l were found in the blood of the deceased. In the absence of other autopsy findings, the deaths in these three cases were finally explained as a result of lethal tolperisone ingestion. To the best of our knowledge, these three cases are the first reported cases of suicidal tolperisone poisonings.     

Internal Validation of Human Mitochondrial DNA Quantification Using Real‐Time PCR

The quantity of mitochondrial DNA (mtDNA) template added for amplification and subsequent dye terminator reactions is critical for obtaining quality sequence data. Validation of a human mtDNA real‐time quantitative PCR (qPCR) assay demonstrated its high degree of reproducibility and precision as well as an extremely sensitive threshold of detection (0.0001 pg/μL or approximately six human mtDNA copies/μL). A study of 35 nonprobative bone and teeth evidence samples revealed that 20 pg of mtDNA template is recommended for successful HV1 and HV2 sequence analysis; however, as little as 0.013 pg can generate a full mtDNA profile when using enhanced amplification reactions. The assay can also detect PCR inhibition and is useful for identifying samples that may benefit from re‐purification. Overall, the assay is an excellent method to quantify mtDNA and is useful for determining the best analytical approach for successful sequencing.     

Using EHRs to design drug repositioning trials: A devolved approach to data protection

One area where the application of data protection law has proven complex is in relation to the secondary usage of health data in EHRs for medical research. Here the tension between the privacy interests of patients and the risk of harm if such sensitive data are compromised, and on the other side, the potential societal value of utilizing the data for the benefit of medical science, is especially striking. In this paper, we consider the applicable provisions of the EU Data Protection Directive, and outline a general approach to patient data handling for research, which we believe to be compatible with relevant legal and ethical requirements. We then illustrate and apply this by reference to a specific EU FP7 project, involving EHR data processing to select patients for clinical pharmaceutical trials. After introducing the project (PONTE), we explain the ‘devolved’ data protection architecture it employs and provide a legal evaluation.     

Right-Wing Authoritarianism and Social Dominance Orientation Predict Different Moral Signatures

Moral Foundations Theory posits five distinct foundations of morality: Harm/Care, Fairness/Reciprocity, In-group/Loyalty, Authority/Respect, and Purity/Sanctity. In combination, this should yield between four-to-six moral signatures—distinct combinations or patterns of support for these aspects of morality. We extend previous research by examining the replicability of these moral signatures in a New Zealand-based national sample (n = 3,635). Latent Profile Analysis identified four distinct moral signatures: Individuators, Moderates, Neutrals, and High Moralists. We integrate these moral signatures within the Dual Process Model (DPM) framework and show that Social Dominance Orientation predicts membership in the Neutral moral signature (moderate/lukewarm support for multiple moral foundations); whereas Right-Wing Authoritarianism predicts membership in the High Moralist signature (undifferentiated high support across moral foundations). These findings were observed controlling for Big-Six personality and various demographics. Thus, the authoritarian and dominance-based motives identified by the DPM independently predict categorical differences in the signatures people use to judge morality.     

Exchange rate volatility and regional trade agreements in Southern Africa

Economic Change and Restructuring - Exchange rate volatility is often perceived to cause a reduction in the overall level of trade. In view of the proliferation of rapid regional trade agreements...     

Public Administration Research in Mainland China: A Systematic Review of Chinese Public Administration in English Language Journals (1996–2016)

This study provides a systematic review of the development of Chinese public administration in English language journals. An analysis of articles in the top 25 English-language public administration journals worldwide from 1996 to 2016 confirmed increases in both the number and significance of studies of Chinese public administration. A systematic content analysis of abstracts of previous studies was performed and showed that social development and administrative reform were among the most important topics. With respect to the methodology of this study, qualitative methods were more frequently used than quantitative or mixed methods. Finally, implications for future research on Chinese public administration are discussed.