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Carisoprodol, meprobamate, and driving impairment 总被引:4,自引:0,他引:4
This paper considers the pharmacology of the centrally acting muscle relaxant carisoprodol, and its metabolite meprobamate, which is also administered as an anxiolytic in its own right. Literature implicating these drugs in impaired driving is also reviewed. A series of 104 incidents in which these drugs were detected in the blood of drivers involved in accidents or arrested for impaired driving was considered, with respect to the analytical toxicology results, patterns of drug use in these subjects, the driving behaviors exhibited, and the symptoms observed in the drivers. Symptomatology and driving impairment were consistent with other CNS depressants, most notably alcohol. Reported driving behaviors included erratic lane travel, weaving, driving slowly, swerving, stopping in traffic, and hitting parked cars and other stationary objects. Drivers on contact by the police displayed poor balance and coordination, horizontal gaze nystagmus, bloodshot eyes, unsteadiness, slurred speech, slow responses, tendency to doze off or fall asleep, difficulty standing, walking or exiting their vehicles, and disorientation. Many of these cases had alcohol or other centrally acting drugs present also, making difficult the attribution of the documented impairment specifically to carisoprodol and meprobamate. In 21 cases, however, no other drugs were detected, and similar symptoms were present. Impairment appeared to be possible at any concentration of these two drugs; however, the most severe driving impairment and most overt symptoms of intoxication were noted when the combined concentration exceeded 10 mg/L, a level still within the normal therapeutic range. 相似文献
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Though much research has been devoted to the socioeconomic and political consequences of International Monetary Fund (IMF) programs for recipient countries, little is known about the impacts of these programs on the level of respect for women’s rights. We postulate that IMF-induced policy reforms of privatization and public spending cuts, and the growing political repression and instability following the implementation of IMF programs, undermine the government’s ability and willingness to protect women’s economic and political rights. To substantiate the theoretical claims, we combine data on women’s political and economic rights with data on IMF programs for the years 1981–2004. Our findings suggest that IMF involvement is likely to deteriorate the level of respect for women’s economic rights while having no discernible effect on women’s political rights. The results further indicate that the effect of these programs is not conditioned by political regime type and economic wealth of recipient countries. One major policy implication of our findings is that the IMF should start to recognize that the conditions attached to lending programs might be implemented at the expense of women’s economic rights and that more explicit protections of women’s rights need to be included in program negotiations. 相似文献
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Janine Schulte MSc Nicole Rittiner MSc Ilona Seiberle MSc Sarah Kron Iris Schulz PhD 《Journal of forensic sciences》2023,68(4):1133-1147
Touch DNA has become increasingly important evidence in todays' forensic casework. However, due to its invisible nature and typically minute amounts of DNA, the collection of biological material from touched objects remains a particular challenge that underscores the importance of the best collection methods for maximum recovery efficiency. So far, swabs moistened with water are often utilized in forensic crime scene investigations for touch DNA sampling, even though an aqueous solution provokes osmosis, endangering the cell's integrity. The aim of the research presented here was to systematically determine whether DNA recovery from touched glass items can be significantly increased by varying swabbing solutions and volumes compared with water-moistened swabs and dry swabbing. A second objective was to investigate the possible effects of storage of swab solutions prior to genetic analysis on DNA yield and profile quality when stored for 3 and 12 months, as is often the case with crime scene samples. Overall, the results indicate that adapting volumes of the sampling solutions had no significant effect on DNA yield, while the detergent-based solutions performed better than water and dry removal, with the SDS reagent yielding statistically significant results. Further, stored samples showed an increase in degradation indices for all solutions tested, but no deterioration in DNA content and profile quality, allowing for unrestricted processing of touch DNA samples stored for at least 12 months. One further finding was a strong intraindividual change in DNA amounts observed over the 23 deposition days which may be related to the donor's menstrual cycle. 相似文献
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Crofting has been subjected to a specific regulatory regime in Scots law since the introduction of the Crofters' Holdings (Scotland) Act in 1886. The Act, introduced in response to the devastation caused by the Highland clearances, provided for security of tenure and associated rights and now provides for full ownership on both individual and collective bases. Consequently, the legal framework incorporates two distinct forms of crofting identity: one based on the crofting function and the other on a broader, place‐based definition incorporating all who live within crofting communities. Used as a basis for policymaking, each definition gives rise to different outcomes. In this paper, we use empirical research to show how such distinctions are manifested in specific conflicts of interest within contemporary crofting communities. This analysis is intended to inform the current debate surrounding the future of crofting as well as to contribute to the wider literature on the use of identity in the process of resource allocation. 相似文献
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Nicole Bulander Burkhard Rolf 《Forensic Science International: Genetics Supplement Series》2009,2(1):104-105
In this study, we used two real time PCR platforms (Roche LightCycler 480 System and the ABI 7900 real time PCR instrument) to compare three commercial kits for DNA quantification. Special emphasis was put on PCR efficiency, detection limit and detection range. Furthermore, we tested the influence of the calibrator DNA included in the different kits on the absolute values. 40 artificial stain samples as well as 40 reference saliva samples were tested and compared. Two main observations could be made: the kits had a strong influence on the amount of DNA determined (Quantifiler® < Quantifiler Duo® < Plexor® kit) whereas the real time PCR platforms showed no significant influence on the outcome. 相似文献
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AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived fro... 相似文献
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