A Direct Aqueous Derivatization GSMS Method for Determining Benzoylecgonine Concentrations in Human Urine

A sensitive and reliable method for extraction and quantification of benzoylecgonine (BZE) and cocaine (COC) in urine is presented. Propyl‐chloroformate was used as derivatizing agent, and it was directly added to the urine sample: the propyl derivative and COC were then recovered by liquid–liquid extraction procedure. Gas chromatography–mass spectrometry was used to detect the analytes in selected ion monitoring mode. The method proved to be precise for BZE and COC both in term of intraday and interday analysis, with a coefficient of variation (CV) <6%. Limits of detection (LOD) were 2.7 ng/mL for BZE and 1.4 ng/mL for COC. The calibration curve showed a linear relationship for BZE and COC (r² >0.999 and >0.997, respectively) within the range investigated. The method, applied to thirty authentic samples, showed to be very simple, fast, and reliable, so it can be easily applied in routine analysis for the quantification of BZE and COC in urine samples.     

‘Let's Talk Cash’: Cantons' Interests and the Reform of Swiss Federalism

In 2004 the Swiss people accepted a new equalization scheme and a new distribution of competences between the federal state and the cantons. It was argued that the reform was successful because of the capacity of veto-players to overcome their interests and adopt a ‘problem-solving’ interaction mode. We propose a different interpretation and argue that distributive issues and the accommodation of actors' interests crucially mattered. We identify three mechanisms that contribute to a successful reform, i.e. package-deals, side-payments and the downsizing of the reform. Our in-depth, mainly qualitative study of both the content of the reform and related decision-making process supports the pertinence of these strategies for the explanation of the successful reform of Swiss federalism.     

International measurement of food security: Enhancing alignment between evidence and assistance programs

A definition of food security used in developing countries by United Nations Agencies, The United States Agency for International Development (USAID) and other international development agencies establish four dimensions of food security: access, availability, utilization, and stability. This definition provides a framework for a multidimensional, rigorous measure of food security across developing countries and enables an analysis of the magnitude and severity of food insecurity across time and space. This framework also permits an analysis of the drivers of food insecurity that foster appropriate, cost‐effective food assistance programs. In the developed world, food security is often defined more narrowly, resulting in a less rigorous measurement of food security. Food security experts in developed countries can exploit the framework applied in the developing world to improve the measurement of food insecurity, as well as evidence‐based food assistance programs that are informed by its measurement.     

New legal provisions on trusts in Italy: back to foundations: an italian retrospective

The article focuses on the enactment of new civil law rulesas well as tax measures in Italy as a consequence of which theauthor expects that high net worth individuals will turn theirattention back to the setting up of foundations instead of trusts,in particular in cases where immovable property is concerned.