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81.
Selin Acar Hilal Erol Elif Keskin Arslan Nusret Uysal Bar Karada Tijen Kaya Temiz Yusuf Cem Kaplan 《法庭科学研究(英文)》2021,6(3):237-239
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression and anxiety disorders. In some epidemiological studies, slightly increased risks of major malformations and cardiac malformations have been reported following paroxetine exposure in the first trimester of pregnancy. However, such findings have been inconsistent. There is only one report of any overdose of an SSRI during pregnancy, and that involved escitalopram. The aim of this case report was to describe the impact of a paroxetine overdose in the first trimester of pregnancy on the health of the foetus. A 21-year-old mother of one child who was pregnant with a second child was prescribed 20 mg/day paroxetine hydrochloride for the treatment of anxiety/depression. The patient ingested 15 or 16 20-mg tablets of paroxetine hydrochloride (300–320 mg) during the 5th week of pregnancy as a suicide attempt. Within 15 min of ingestion, she was admitted to hospital and treated for intoxication. No evidence of maternal SSRI intoxication was observed after treatment. The patient consulted our teratology information service for further risk assessment regarding possible major congenital malformations following the paroxetine overdose. We were unable to find previous reports of paroxetine overdose during pregnancy in the literature. The timely administration of the overdose treatment and the lack of maternal intoxication symptoms were considered positive for the foetal well-being, and the patient was referred for perinatology and psychiatry follow-ups. A healthy, 3 500-g male infant was born at 38 weeks’ gestation, and his development at the age of 2 years was normal. This is the first reported case of paroxetine overdose during pregnancy. Comprehensive studies are needed to evaluate pregnancy outcomes after SSRI overdose.
Key Points
- There are no reported data on paroxetine overdose during pregnancy.
- The aim of this case report was to describe the impact of a maternal paroxetine overdose in the first trimester of pregnancy on the health of the foetus. No evidence of maternal SSRI intoxication was observed.
- No congenital malformations or developmental disorders were observed in the child at 2 years of age.
- Comprehensive studies are needed to evaluate pregnancy outcomes following SSRI overdose.
82.
83.
人力资源管理思想:三个里程碑及其在中国的升华 总被引:2,自引:0,他引:2
人力资源管理实践历程中三个标志性实验成果昭示了人力资源管理思想演变的客观规律,是人力资源管理思想嬗变过程中的三大里程碑。科学管理实验使人力资源管理从自发管理走向自觉管理、科学管理和制度管理;霍桑实验系统发现了提高生产效率的社会心理因素,使人力资源管理从技术管理走向社会管理、行为管理和心理管理;职业生涯实验显示员工职业发展也是现代企业管理目标,现代企业目标和员工职业发展目标共存共长。三次实验的思想脉络、理论构造、功能机制有机对接、联动传承并推向纵深,成为人力资源管理历史上三个具有划时代意义的丰碑。科学人才观提出的"以人为本"的思想和理念是人力资源管理思想在当代中国的发展和升华。 相似文献
84.
当前学者们对中国核战略的争论焦点在于,没有任何一种现有核战略定义能够完全涵盖中国核政策的特点。本文认为,正确理解中国核战略,需要摆脱现有核战略理论概念体系的束缚。只有从中国核战略产生和发展的具体时代背景中寻找线索,才能认识到,中国核战略经历了从反核威慑战略到最低核威慑战略的巨大转变,而中国长期大规模备战核战争遗留下来的物质遗产和思想基础,仍然对中国核战略产生着巨大的影响力。中国学者应从中国核战略实践出发,参与构建主流话语体系,为核战略学科建设做出自己的贡献。 相似文献
85.
任何全球减排路线图的绘制都无法脱离国际正义而具有生命力。气候变化问题的特性要求全球减排路线图尊重具有两面性的国际气候正义:环境正义和发展正义,需要考虑国家间公平、人的公平和代际公平。仅以人类发展指数(HDI)作为衡量国家承担减排责任的标准缺乏足够的正义,至少还需要加入人均历史累积排放和气候变化脆弱性两个指标。三者分别体现气候变化正义性中的人的平等发展权、减排责任分担和对受害者在排放权上的补偿。综合三大指标后的四分组分类,才是更体现正义性、更容易被接受和执行的路线图。从正义性出发,中国应承担相应的减排责任,并努力推动全球减排进程,但也要注意维护自身的发展权益。中国在全球减排中的作为,应是在国际正义与国家发展战略间取得平衡。 相似文献
86.
Facial reconstruction is the approximation of an antemortem face from human skeletal remains. Since the nineteenth century, several methods have been developed for reconstruction of the face; all of them require the measurement of average tissue thicknesses at various points on the face. To our knowledge, there are no publications on soft tissue thickness in the Turkish population. In addition, there are few publications on the value of magnetic resonance imaging (MRI) in measuring soft tissue thickness for forensic sciences. The aim of this study was to create a reference database of facial tissue thickness in the Turkish population, and to present data illustrating the successful use of MRI for this purpose. The study included 161 patients (79 males and 82 females) between the ages of 18 and 78 who had undergone brain MRI in our radiology clinic, and showed no sign of maxillofacial pathology. Measurements were taken at 9 points at the midline; glabella, nasion, end of nasals, mid-philtrum, upper lip margin, lower lip margin, chin-lip fold, mental eminence, and beneath chin points. The mean values for these points in the patient sample population were determined, and differences related to age, sex, and body mass index (BMI) were calculated. The values were then compared to the findings of the Manhein study. 相似文献
87.
Zhang Chuyun is a PhD Candidate at School of Economics Management Tongji University Shanghai Sun Yuchun is a Professor at School of Economics Management Tongji University Shanghai 《中国行政管理》2008,(8)
本文运用信息经济学理论来解释和分析在公务员考录过程中存在的信息不对称问题,如逆向选择、道德风险和"学历高消费"等。针对这些信息不对称问题,本文提出:保证政府部门能经济、有效地吸收录用广大社会优秀人才,一方面,要在职位分类的基础上,建立分类分级考试制度和实行专业技术岗位聘任制以克服逆向选择问题;另一方面,设计合理有效的考试录用机制,大力加强政府部门的信息化工作,扩大考任制实施范围等以减少道德风险和"学历高消费"的问题。 相似文献
88.
K. A. Thulitha Wickrama MS K. A. S. Wickrama Ph.D Chalandra M. Bryant PhD 《Journal of youth and adolescence》2006,35(4):641-651
Using a sample of 20,000 adolescents (Add Health data), this study examined the influences of community poverty and race/ethnicity on adolescent obesity. Multilevel analyses revealed strong evidence for the unique influences of community poverty and race/ethnicity on adolescent obesity net of family characteristics. The prevalence of obesity is significantly higher in poor communities than in affluent communities; and it is higher among African Americans, Hispanics and Native Americans than among Whites. The interaction between race/ethnicity and community poverty indicates that race/ethnicity moderates the influence of community poverty on the prevalence of obesity. Although the prevalence of obesity is higher among minorities than among Whites, the influence of community poverty is stronger for Whites than for minorities, suggesting that unlike Whites, most minority groups may not accrue benefits of structural community advantages. The state of being overweight as the outcome variable provided essentially the same findings. The practical implications are discussed. 相似文献
89.
This study examined changes in extreme weight change attitudes and behaviors (exercise dependence, food supplements, drive for thinness, bulimia) among adolescent boys and girls over a 16 month period. It also investigated the impact of body mass index, puberty, body image, depression and positive affect on these attitudes and behaviors 16 months later. The participants were 847 young adolescents (411 boys, 436 girls). Participants completed questionnaires evaluating the above variables on three occasions, eight months apart. Girls obtained higher scores on exercise dependence, drive for thinness and bulimia. Changes in depression and body image importance were the strongest predictors of changes in these extreme attitudes and behaviors among boys; changes in depression, body dissatisfaction and body image importance were the strongest predictors for girls. The need for gender specific educational and intervention programs for adolescents are discussed.Marita McCabe PhD, Professor in Psychology in the School of Psychology, Deakin University, Melbourne, Australia. She has completed her PhD in 1981 on adolescent development, and has been completing research on various aspects of adolescent adjustment for 30 years. To whom correspondence should be addressed at 221 Burwood Highway, Burwood, Victoria 3125, Australia;Senior Lecturer in the School of Psychology, Deakin University, Melbourne Australia. She completed her PhD in 1990 on Childrens Language Development. In the last 10 years she has been researching body image concerns in adolescents and children 相似文献
90.
This exploratory study examined juvenile drug courts’ effect on adulthood recidivism. Utilizing a twelve-year average follow up time, adult recidivism rates were compared between previous juvenile drug court participants and a comparison group of juveniles who participated in traditional probation. Linear regression models indicated limited recidivism effects of drug court on arrests or convictions into adulthood. The findings suggest that gender and race may play a role in how justice-involved juveniles interact and experience juvenile drug court, highlighting the need for gender-responsive and culturally responsive policies, practices, and programs within juvenile drug courts. Recommendations are made regarding future research areas and ways to potentially improve long-term juvenile drug court outcomes. 相似文献