Pseudomesotheliomatous carcinoma of the lung with asbestos exposure

A case of peripheral lung carcinoma clinically and anatomically simulating a malignant mesothelioma in a man who had been exposed to silicium as well as asbestos during more than 20 years of employment in industry is presented. Results of the microscopic examination of routine, stained sections were inconclusive and the importance of demonstrating mucin in the neoplastic cells by use of special staining is emphasized.     

A fast preparation of skeletal materials using enzyme maceration

The current study investigates the removal of soft tissues from mice and rats by the use of three different proteases and one lipase from Novozymes A/S. The results demonstrate the enzyme maceration to be remarkably fast (1-3 h) compared to the traditional warm-water procedure, which requires up to several days. In addition, the enzyme maceration eliminates the odor problem associated with the traditional procedure. It is shown that stirring of the enzyme maceration bath is the main factor which determines the speed of the maceration. For mice, the time required for enzyme maceration can vary from 1 to 8 h depending on the stirring speed. The method investigated here allows preparation of skeletal material in an essentially odorless way within a matter of hours, making the method useful in particular for forensic science, private conservation workshops, and educational purposes.     

Presence of psychoactive substances in oral fluid from randomly selected drivers in Denmark

The aim of this investigation was to identify and characterise pathogenic mutations in a sudden cardiac death (SCD) cohort suspected of cardiomyopathy in persons aged 0-40 years. The study material for the genetic screening of cardiomyopathies consisted of 41 cases and was selected from the case database at the Institute of Forensic Medicine. Mutational screening by DNA sequencing was performed to detect mutations in DNA samples from deceased persons suspected of suffering from hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and arrhythmogenic right ventricle cardiomyopathy (ARVC). A total of 9 of the examined 41 cases had a rare sequence variant in the MYBPC3, MYH7, LMNA, PKP2 or TMEM43 genes, of which 4 cases (9.8%) were presumed to be pathogenic mutations. The presumed pathogenic mutations were distributed with one case of suspected HCM and DCM (MYH7; p.R442H), one case of suspected DCM (LMNA; p.R471H), and two cases of suspected ARVC (PKP2; p.R79X and LMNA; p.R644C). The presented data adds important information on the genetic elements of SCD in the young, and calls for expert pathological evaluation and molecular autopsy in the post-mortem examination of SCD victims with structural anomalies of the heart.     

Citizens and Resource Allocation: Improving Decision Making with Interactive Web-Based Citizen Participation

Collective consumption and benefit characterize many government services. Moreover, government services are mostly paid for collectively through taxes—there is little or no relationship between the taxes paid by a household and its use of a particular service. Public sector decision makers face complex budget problems with difficult solutions. Involving citizens meaningfully in these decisions has long been a conundrum. The authors teamed up with the town of West Hartford, Connecticut, to develop a Web-based survey to overcome some of these participation problems and help decision makers better understand citizen preferences. The Web survey allowed for real-time interactivity and was tailored to present respondents with trade-offs between service levels and taxes.     

Postmortem red coloration of teeth. A retrospective investigation of 26 cases

Postmortem red coloration of teeth (pink teeth) was found in 26 of 119 consecutive autopsy or forensic dental identification cases during 1973-1984. The present study confirms that red coloration of teeth may occur some time after death under conditions that promote putrefaction and adipocere formation. The red coloration is due to hemolysis after exudation of hemoglobin derivatives through the dentine tubules in cases in which blood has accumulated in the head, either due to congestion or by a postmortem head-down position, as after submersion in water.     

Sudden death due to bilateral spontaneous pneumothorax caused by rupture of congenital lung cysts

A case of sudden death of a 35-year-old woman due to spontaneous bilateral pneumothorax from rupture of congenital lung cysts is reported. The woman had been attended by two doctors before the lethal outcome. The medicolegal aspects pertaining to medical negligence, the diagnostic difficulties and the rare occurrence of the condition are discussed, as is the autopsy procedure.     

Results of the 2009 Paternity Testing Workshop of the English Speaking Working Group of the International Society for Forensic Genetics

Here we present the results of the 2009 Paternity Testing Workshop of the English Speaking Working Group of the International Society for Forensic Genetics. The exercise included paternity testing of blood samples from a mother, a child and two alleged fathers. The laboratories were encouraged to answer questions concerning their laboratory routines and a paper challenge was distributed in order to compare statistical calculations. A total of 62 laboratories participated. The laboratories used a total of 49 autosomal STRs and PCR-investigated VNTRs, 19 Y-chromosomal STRs, 8 X-chromosomal STRs, 7 VNTR systems investigated with RFLP, 49 autosomal SNPs and 11 mtDNA SNPs. The rate of typing and reporting errors was 0.1%.     

Do Debt Policies Make a Difference in Finance Officers' Perceptions of the Importance of Debt Management Factors?

This article explores the importance of various debt policy factors using a national survey of government finance officers. Further, it examines whether the presence of a particular factor in a debt policy influences finance officers' perception of its importance. We find that debt policies tend to be technical in nature and that broad policy issues are most often not included in debt policies. Moreover, we find that the inclusion of debt management factors in debt policies has a powerful influence on their perceived importance by public managers.