Development of a harmonised method for the profiling of amphetamines: III. Development of the gas chromatographic method

This study focused on gas chromatographic analysis of target compounds found in illicit amphetamine synthesised by the Leuckart reaction, reductive amination of benzyl methyl ketone, and the nitrostyrene route. The analytical method was investigated and optimised with respect to introduction of amphetamine samples into the gas chromatograph and separation and detection of the target substances. Sample introduction using split and splitless injection was tested at different injector temperatures, and their ability to transfer the target compounds to the GC column was evaluated using cold on column injection as a reference. Taking the results from both techniques into consideration a temperature of 250 degrees C was considered to be the best compromise. The most efficient separation was achieved with a DB-35MS capillary column (35% diphenyl 65% dimethyl silicone; 30 m x 0.25 mm, d(f) 0.25 microm) and an oven temperature program that started at 90 degrees C (1 min) and was increased by 8 degrees C/min to 300 degrees C (10 min). Reproducibility, repeatability, linearity, and limits of determination for the flame ionisation detector (FID), nitrogen phosphorous detector (NPD), and mass spectrometry (MS) in scan mode and selected ion monitoring (SIM) mode were evaluated. In addition, selectivity was studied applying FID and MS in both scan and SIM mode. It was found that reproducibility, repeatability, and limits of determination were similar for FID, NPD, and MS in scan mode. Moreover, the linearity was better when applying FID or NPD whereas the selectivity was better when utilising the MS. Finally, the introduction of target compounds to the GC column when applying injection volumes of 0.2 microl, 1 microl, 2 microl, and 4 microl with splitless injection respectively 1 microl with split injection (split ratio, 1:40) were compared. It was demonstrated that splitless injections of 1 microl, 2 microl, and 4 microl could be employed in the developed method, while split injection and splitless injections of 0.2 microl should be avoided.     

Empathetic trappings: Revisiting the nineteenth century in Octavia Butler's Kindred

Octavia Butler's 1979 novel, Kindred, is a postmodern slave narrative that redefines the previous literary constructions of slavery in the United States. Through its rejection of the nineteenth century slave narrative and sentimental novel, Kindred highlights the main problem with nineteenth century narrative empathy: Forging an intimate identification between reader and character to enact empathy is founded through the representation of bodies in pain. In place of this identification tactic, Kindred reveals a new critical apparatus, essential for a mobilization of empathy centered on understanding both history and the process of historical recuperation. This investigation of empathy sheds light on the problematic construction of the early liberal human rights model across the Americas, a model centered on promoting identification with the suffering other.     

The Digital Revolution

Throughout my school life,phones offered one significant benefit:a means of communication,via either text or call.Typing out a message,“back in the day,”required quite the skill set,i.e.,understanding the code of the numbered buttons.