Development of a harmonised method for the profiling of amphetamines VI: Evaluation of methods for comparison of amphetamine

Amphetamine samples were analysed by gas chromatography-mass spectrometry (GC-MS), and the peak areas of 33 target compounds were transformed by applying various pretreatment techniques. The objective was to optimise the ability of a number of distance metrics to establish links between samples of amphetamine originating from the same batch (henceforth referred to as linked distances). Furthermore, partial least squares discriminant analysis (PLS-DA) was used to evaluate the effects of various pretreatment methods on separation of amphetamine batches synthesised by the Leuckart reaction, reductive amination of benzyl methyl ketone, and the nitrostyrene route. The most efficient way to pretreat GC-MS data varied for the different distance metrics, although best results were obtained when data were normalised to the sum of peak areas, and either the fourth root or a logarithm was applied to the normalised data. When pretreating normalised data by fourth root transformation, Pearson correlation was the distance metric that was most successful at finding linked samples. Normalisation and the use of fourth root also represented the best method of pretreating data when employing PLS-DA to separate samples synthesised by different routes. To achieve a faster and more user-friendly procedure for evaluating chromatograms, experiments were performed in which the number of target compounds used to compare samples was reduced. The effect of each compound that was removed was studied by applying PLS-DA and by using Pearson correlation to calculate linked distances as well as unlinked distances (between samples from different batches of amphetamine). Considering both links between samples from the same batch and separation of samples synthesised by different routes, the best results were obtained with the data set comprising 26 compounds. Finally, it was found that the profiling method developed in this work was superior to an existing technique with respect to separating linked and unlinked distances.     

Capital Accumulation,Hegemony and Socio-ecological Struggles: Insights from the ENTITLE Project

This special issue presents findings and reflections of scholars who participated in the European Network of Political Ecology (ENTITLE). By mobilising conceptual frameworks from several strands of Marxist and post-structuralist theory—and empirically engaging with a range of historico-geographical processes—the articles in this issue contribute to debates in political ecology in two main ways. First, they critically analyse the political economy and ecology of contemporary capitalism, with an emphasis on accumulation strategies associated with the uneven expansion and crisis of neoliberalism. Specifically, they unpack and critically extend the frameworks of “accumulation by dispossession” and “nature's neoliberalisation” to engage with, among other cases, the political ecology of “austerity” in Southern Europe; historical and contemporary cases of “capital-driven disasters”; and political ecological dynamics taking place around relationships of “rent”. Second, the authors of this special issue analyse new and re-emerging forms of socio-ecological resistance and contestation, including both distributional struggles and movements against “commons' enclosures”. Moreover, they focus on how struggles can (and do) move from contesting capitalist forms of dispossession towards creating alternative “hegemonic” projects and blocs, by critiquing received “common sense” and constructing and performing alternative political ecological imaginaries informed by principles of solidarity and “commoning”. Taken together, the articles in this special issue present new ways of thinking and enacting political and ecological struggles outside established scholarly traditions and conventional disciplines.     

Detention and the Evolving Threat of Tuberculosis: Evidence, Ethics, and Law

The issue of detention as a public health control measure has attracted attention recently. This is because the threat of strains of tuberculosis that are resistant to a wider range of drugs has been identified, and there is renewed concern that public health is threatened. This paper considers whether involuntary detention is justified where voluntary measures have failed or where a patient poses a danger, albeit uncertain, to the public. We discuss the need for strengthening evidence-based assessments of public health risk and suggest that we should reflect more profoundly on the philosophical foundations upon which our policies and practices are grounded.     

The evidential value of singed hairs in arson cases

The prevalence of singed hairs on hands was examined in a representative sample comprised primarily of Hamburg LKA staff members to determine the evidential value of such traces in criminal cases. Hair samples were taken from the hands of 160 subjects and examined under a microscope. Evidence of singing was found in 53 of the samples. These traces were largely restricted to a limited number of areas. Distribution of singed hairs over a wide area was observed in just 3 subjects all of whom reported contact with an open flame. The presence of singed hair on the back of the hand can be of great evidential value, though the corresponding distribution pattern must be carefully interpreted.     

Lobbying business interests in Russia

Our article examines business lobbying in contemporary Russia within the wider context of lobbying in the decision‐making system overall. It is argued that, although lobbies were an important part of the old Soviet system, the defence of corporate interests was held within ‘natural’ limits by an overriding concern to maintain the established consensus ‐ in the form of a bureaucratic corporatist economy. In the perestroika and post‐perestroika years, however, lobbies themselves took front stage becoming the decisive element in the economy. Easily the most important, in terms of economic strength and political influence, were the various business interest groups, which we have attempted to classify according to their lobbying potential and the channels of influence available to them. The peculiarities of business interest lobbying are also considered, including the as yet unsatisfied quest for political representation, the tendency for management and employees to ‘row together’, the huge potential of uncontrollable lobbying ‘from below’ in the face of growing social tensions and, finally, the disparity between lobbying and other forms of state‐society relations.     

Attitudes Toward Intimate Partner Violence Against Women in Moscow,Russia

This study examines attitudes towards violence against women among the populace in Moscow, Russia using data drawn from the Moscow Health Survey. Information was obtained from 1,190 subjects (510 men and 680 women) about their perceptions of whether violence against women was a serious problem in contemporary Russia, and under what circumstances they thought it was justifiable for a husband to hit his wife. Less than half the respondents thought violence was a serious problem, while for a small number of interviewees there were several scenarios where violence was regarded as being permissible against a wife. Being young, divorced or widowed, having financial difficulties, and regularly consuming alcohol were associated with attitudes more supportive of violence amongst men; having a low educational level underpinned supportive attitudes among both men and women. Results are discussed in terms of the public reemergence of patriarchal attitudes in Russia in the post-Soviet period.     

Regional governors and the Kremlin: the ongoing battle for power

This article examines the relationship between heads of regional administrations (governors) and the federal government in Russia since 1992. It looks at the methods with which governors have enhanced their powers vis-a-vis Moscow and at the policies of the federal authorities aimed at preserving some form of control over regional officials. The article argues that the gubernatorial elections of September 1996–March 1997, which gave almost all governors a popular mandate, will not considerably change the balance of power in center-periphery relations, despite fears to this effect among members of the Presidential Administration.     

The 1689 Bill of Rights

Following the disastrous reign of James II, the Bill of Rights was introduced to curb future arbitrary behaviour by the Crown. Five of the thirteen Articles are still active and cases illustrating their use in the courts are described. The courts have enforced the requirement for parliamentary consent to taxation and the ban on the executive's power to suspend statutes but have been less strict over the dispensing power. Article 9, on parliamentary freedom of speech, is in active use, and developments in Australia and Canada are reviewed. Scotland's own legislation - the Claim of Right - is discussed briefly. Most of the Bill probably does not apply to Northern Ireland. Opinions vary on the Bill's importance but in the author's view it is still a potent force.     

Depressive disorders and depressive personality traits in offspring aged 10–17 of bipolar and of normal parents

Sixty proband children (P) of bipolar I parents and 60 control children of normal parents (C), in the age range 10–17, were investigated clinically by K-SADS-E interview and psychologically by personality inventories. In the global psychopathology rate of 63% in P children and 25% in C children, depressive disorders reached 8% in P children and 0% in C children, while depressive personality traits reached 22% in P children and 15% in C children. Cluster analysis evidenced a variety of personality structures, but 3 clusters were striking: a cluster characterized by high anxiety and depressive reactivity (17% P and 5% C children), a cluster characterized by high depressive reactivity and emotional instability (5% P children), and a hyperthymic cluster (5 % P children). Sixty-seven percent of P children and 36% of C children showed deviant personality traits (p<.01).