电针激活Nrf2/HO-1通路抗帕金森病模型小鼠氧化应激的机制研究

目的 观察电针“风府”“太冲”“足三里”穴对帕金森病(Parkinson’s disease, PD)模型小鼠大脑纹状体中酪氨酸羟化酶(tyrosine hydroxylase, TH)、核因子E2相关因子2(nuclear factor-erythroid 2-related factor 2,Nrf2)、血红素加氧酶-1(heme oxygenase-1,HO-1)水平的影响,探讨电针治疗PD的可能机制。方法 将30只小鼠按随机数字表法分为对照组、模型组和电针组,每组10只。模型组、电针组小鼠按照30 mg/kg腹腔注射1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, MPTP)制备PD小鼠模型。电针组小鼠给予“风府”“太冲”“足三里”穴电针干预,每日1次,每次30 min,连续干预12 d。其余两组小鼠不予任何干预。采用爬杆实验和悬挂实验观察3组小鼠行为学改变,旷场实验观察小鼠自主运动总路程,免疫组织化学法检测小鼠大脑纹状体中TH表达水平,实时荧光定量PCR法检测小鼠大脑纹状体中Nrf2、超氧...     

芪白平肺胶囊对慢性阻塞性肺疾病痰瘀阻肺证大鼠血清CAM-2和VEGF的影响

目的 观察芪白平肺胶囊对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)痰瘀阻肺证大鼠血清钙调节蛋白-2（calmodulin-2,CAM-2）和血管内皮生长因子(vascular endothelial growth factor, VEGF)的影响,探究其作用机制。方法 将280只SD大鼠随机分为正常组（60只）、模型组（60只）、芪白平肺胶囊预防组（芪预组,40只）、芪白平肺胶囊治疗组（芪治组,40只）、尼可地尔预防组（尼预组,40只）、尼可地尔治疗组（尼治组,40只）。采用连续4周的强迫游泳、烟熏和低氧应激的复合方法复制COPD痰瘀阻肺证大鼠模型。正常组和模型组分别在实验第4周、第8周、第12周各处死20只大鼠,检测血清CAM-2和VEGF水平;芪预组和尼预组均在模型复制同时预防性给药4周,分别在实验第4周、第8周各处死20只大鼠,检测血清CAM-2和VEGF水平;芪治组和尼治组均在模型复制结束后连续给药4周,分别在实验第8周、第12周各处死20只大鼠,检测血清CAM-2和VEGF水平。结果 两因素方差分析结果显示,模型因素和时间因素对大鼠血清CAM-2和VEGF水平的主效应及其交互作用均具有统计学意义（P<0.05）。在实验第4周、第8周、第12周,模型组大鼠血清CAM-2水平均显著低于正常组（P<0.05）,血清VEGF水平均显著高于正常组（P<0.05）。与同时间模型组比较,尼预组和芪预组大鼠血清CAM-2水平显著升高（P<0.05）,而血清VEGF水平显著降低（P<0.05）。与同时间尼预组比较,芪预组CAM-2水平显著升高（P<0.05）,VEGF水平显著降低（P<0.05）。与同一时间模型组比较,芪治组和尼治组大鼠血清CAM-2水平显著升高（P<0.05）,VEGF水平显著降低（P<0.05）;在实验第12周,芪治组大鼠血清VEGF水平显著低于尼治组（P<0.05）。结论 芪白平肺胶囊和尼可地尔预防性给药和治疗性给药均可调节COPD痰瘀阻肺证大鼠血清CAM-2和VEGF的异常,芪白平肺胶囊的远期效应优于尼可地尔。     

Using "Shocks and Rumors" to Teach Adaptive Thinking

The business landscape is constantly changing. Moreover, because of globalization, increased competition, and instant communication, the rate of change is accelerating. A student who has practiced only static scenarios is ill prepared to recognize, process, or adapt to changing negotiation issues and interests. Thus, negotiation instructors must change our practices to prepare students to succeed in the increasingly dynamic negotiation situations they will face by utilizing simulations that are also dynamic. This article reviews research on adaptive thinking, applies it to negotiation training, and provides examples of dynamic simulations that require students to adapt. Finally, it offers advice on how to make existing cases dynamic by using "shocks and rumors."     

论公安机关在构建和谐社会中职能作用的发挥

构建社会主义和谐社会是一项宏大而长远的系统工程。公安机关在这一伟大工程中负有神圣使命与重大历史责任。为此,必须深刻理解和谐社会的内在涵义,找准公安工作的切入点,从根本上解决在影响构建和谐社会过程中出现的诸多问题,充分发挥公安机关的职能作用,为构建和谐社会服务。     

Status of Mandibular Third Molar Development as Evidence in Legal Age Threshold Cases

The completion of the third molar roots has played an important role in ascertaining whether individuals may be at or over a legal threshold of age, often taken as 18 years. This study demonstrates that root apex completion in the third molar is relatively uninformative regarding the threshold of age 18 years in a sample of 1184 males, where mean age‐of‐attainment of root apex completion for third mandibular molars is about 19.4 years. This paper also considers the legal age threshold problem for cases where the third mandibular molar is not completely formed, and outlines the use of parametric models and Bayes’ factors to evaluate dental evidence in statistically appropriate ways. It attempts to resolve confusion over age‐within‐stage versus age‐of‐attainment, likelihood ratios versus other diagnostic tests, and prior odds for a case versus the prior density for an age distribution.     

A method for calculating the strength of evidence associated with an earwitness's claimed recognition of a familiar speaker

The present paper proposes and demonstrates a method for assessing strength of evidence when an earwitness claims to recognize the voice of a speaker who is familiar to them. The method calculates a Bayes factor that answers the question: What is the probability that the earwitness would claim to recognize the offender as the suspect if the offender was the suspect versus what is the probability that the earwitness would claim to recognize the offender as the suspect if the offender was not the suspect but some other speaker from the relevant population? By “claim” we mean a claim made by a cooperative earwitness not a claim made by an earwitness who is intentionally deceptive. Relevant data are derived from naïve listeners' responses to recordings of familiar speakers presented in a speaker lineup. The method is demonstrated under recording conditions that broadly reflect those of a real case.     

Forensic Analysis of Digital Dynamic Signatures: New Methods for Data Treatment and Feature Evaluation

This study explored digital dynamic signatures containing quantifiable dynamic data. The change in data content and nature necessitates the development of new data treatment approaches. A SignPad Omega digitizing tablet was used to assess measurement reproducibility, as well as within‐writer variation and the occurrence of correctly simulated features. Measurement reproducibility was found to be high except for pressure information. Within‐writer variation was found to be higher between days than on a same day. Occurrence of correct simulation was low for features such as signature size, trajectory length, and total signature time. Feature discrimination factors combining within‐writer variability and the occurrence of correctly simulated features were computed and show that signature size, trajectory length, and signature time are the features that perform the best for discriminating genuine from simulated signatures. A final experiment indicates that dynamic information can be used to create connections between simulation cases.     

Influence of acculturation strategies on the judgement and punishment of an offender of North African descent

Very few studies have examined the influence of the acculturation strategies of an offender of foreign descent on the way a third party judges the personality and action of that offender. The aim of our study was thus to measure the effect of three variables (Seriousness of the harm suffered by the victim; Type of acculturation strategy of the offender; Level of Social Dominance Orientation [SDO]) of the person making the judgement) on the judgements and decisions made by a sample of students faced with a situation of physical aggression committed by a man of North African descent living in France. After reading a scenario describing a criminal act committed by a man of North African descent, who had or had not adopted French culture, 168 French students completed a judgement scale concerning the criminal act and the offender and an SDO scale. The results show that the crime was perceived as less serious when the perpetrator had adopted French culture than when he had not. The perpetrator was also judged less severely. Participants with higher levels of SDO advocated harsher punishment and attributed the crime to the offender’s personality. We discuss these results and identify new avenues for research.     

The Sexual Violence Risk-20: factor structure and psychometric properties

Although the Sexual Violence Risk-20 (SVR-20) is widely used, its psychometric properties have only been investigated in a limited number of studies. This study explored the factor structure of the SVR-20 and examined its psychometric properties. Confirmatory factor analysis (CFA) was used to examine the fit of the original three-domain model of the SVR-20. The CFA showed that the original structure was not satisfactory. Exploratory principal components analysis (PCA) was conducted in search of a more optimal factor structure. Psychometric properties (i.e., internal consistency, predictive value, and convergent validity) of both the original domains and alternative factors were investigated. The PCA and subsequent CFAs pointed in the direction of an alternative, more optimal three-factor solution. The three alternative factors were labeled as Antisociality, Sexual deviance, and Problematic thinking and produced better internal consistency coefficients than the original domains. However, the validity of the SVR-20 was modest and no evidence was found indicating that the alternative factors were better in this regard as compared to the original domains. Despite the overall superiority of actuarial measures in predicting recidivism, the structured professional judgment of the SVR-20 proved to be more predictive of sexual, violent, and general recidivism than its actuarial scoring method.     

法治视野下的警察执法违法行为规制

近年来,新闻媒体不断披露的有关公安机关或人民警察违法犯罪案件,引起人们对公安机关及人民警察的极大关注。不仅对警民关系的健康发展造成影响,而且带来“法律信仰”危机。“执法者违法”现象的形成固然有执法者自身素质不高等原因,但其根源在于我国现有警察制度自身的缺陷。通过分析我国警察制度的现状,从制度层面上分析“执法者违法”现象的产生原因,探析现有警察制度存在的不足,进而提出制度改革的若干意见。