黄芪-丹参对动脉粥样硬化大鼠肠道菌群的影响

目的 研究黄芪-丹参对动脉粥样硬化（atherosclerosis，AS）大鼠肠道菌群的影响。方法 将大鼠随机分为空白组、模型组、辛伐他汀组（1 mg/kg）、黄芪-丹参组（0.75 g/kg），采用高脂饲料喂养联合腹腔注射维生素D3 8周的方法复制AS模型，同时灌胃给药。采用自动生化分析仪检测大鼠血清总胆固醇（total cholesterol, TC）、三酰甘油（Triacylglycerol, TG）、低密度脂蛋白胆固醇（low-density lipoprotein cholesterol, LDL-C）水平，采用酶联免疫吸附试验检测血清肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）、白细胞介素-6（interleukin-6,IL-6）、白细胞介素-1β（interleukin-1β，IL-1β）水平，光学显微镜下观察胸主动脉病理变化，采用生物信息分析方法观察大鼠结肠内容物肠道菌群变化。结果 与空白组比较，模型组大鼠血清TC、TG、LDL-C、TNF-α、IL-6、IL-1β水平明显升高（P<0.05），HDL-C水平明显降低（P<0.05），胸主动脉血管内皮损伤严重，可见明显蓝色钙状斑块，结肠内容物肠道菌群Berger-Parker、Simpson指数明显降低（P<0.05），放线菌门（Actinobacteria）、乳杆菌属（Lactobacillus）、双歧杆菌属（Bifidobacterium）和杜氏杆菌属（Dubosiella）群落丰度明显降低（P<0.05），变形菌门（Proteobacteria）、疣微菌门（Verrucomicrobia）以及布劳特氏菌属（Blautia）、unclassified_f_Ruminococcaceae和Lachnospiraceae_NK4A136_group群落丰度明显升高（P<0.05）。与模型组比较，黄芪-丹参组大鼠血清血脂和炎症因子水平明显改善（P<0.05），胸主动脉血管内皮无明显损伤及增厚，大致恢复正常，结肠内容物肠道菌群Berger-Parker、Simpson指数明显升高（P<0.05），放线菌门、乳杆菌属、双歧杆菌属和杜氏杆菌属群落丰度明显升高（P<0.05），变形菌门、疣微菌门以及布劳特氏菌属、unclassified_f_Ruminococcaceae和Lachnospiraceae_NK4A136_group群落丰度明显降低（P<0.05）。〖JP〗结论 黄芪-丹参治疗AS的作用机制可能是通过调控肠道菌群改善血脂代谢和抑制炎症水平实现的。     

The Future of Northern Ireland: the Role of the Belfast/Good Friday Agreement Institutions

Since the 2016 Brexit referendum a series of crises has gripped Northern Ireland's politics. This has had a destabilising effect across society, which has arguably been felt most acutely by political unionism. The Belfast/Good Friday Agreement (B/GFA) of 1998 created a series of institutions to deal with political conflict in Northern Ireland, manage cross-border cooperation and normalise relations between the UK and Ireland. However, many aspects of it have been sparingly and ineffectually deployed, most notably the second and third strands dealing with north/south and east/west relations respectively. In this article, the authors argue that regular use of the institutional arrangements created by the Agreement would help to deal with the challenges currently facing Northern Ireland and help address unionist anxieties over the Protocol. Use of the North-South Ministerial Council (NSMC), the British Irish Council (BIC) and the British-Irish Intergovernmental Conference (BIIGC) should be prioritised. The unresolved issues arising from Brexit require a recommitment to the intergovernmental logic at the heart of the 1998 Agreement, despite the obstacles.     

数字社会治理的权利逻辑:以个人信息权为中心

以信息技术为核心的数字社会迅速发展,促进多元主体信息交流和资讯共享,给个人信息保护带来挑战。作为数字社会公民身份的基本表征,个人信息权既是数字公民实现全面自由发展的先决条件,也是防范和控制数字权力异化的重要工具。实现数字社会个人信息权保护的价值追求,国家立法机关应秉持作为宪法价值核心的人格尊严进行立法,明晰个人信息权的规范内涵与保护机制;行政机关应遵循权力法定原则,严格基于法律保留、公共利益和比例原则处理和使用个人信息,并建立专门的个人信息权保护的监管机构;司法机关应通过法律适用和司法解释对被侵犯的个人信息权提供及时司法救济,填补法律漏洞,实现数字社会个人信息权保护的制度正义目标。     

Reproductive health services: “Business-in-a-Box” as a model social innovation

Access to reproductive health services and products in remote and rural communities is a critical area of concern for developing countries. This article considers a pilot intervention in three districts of Pakistan where “Business-in-a-Box” as a model of place-based social innovation is used to improve the socio-economic conditions of women in remote rural settings through socially responsible micro-franchising. It finds that such programmes help build a sense of community, ownership and grassroots capabilities and skills. The article also discusses the impacts of such actions on the individual and community life, and the need to upscale and sustain these initiatives.     

浮动抵押逸出担保物权体系的理论证成

具有担保功能的权利,并非都是担保物权。如果一项权利既不符合担保物权的特征,亦有违物权法的基本原则,就不属于担保物权。对比浮动抵押与担保物权的特征可以发现,浮动抵押有担保功能但并非担保物权。在民法典编纂背景下,宜将浮动抵押从担保物权体系剔除。考察比较法资料,结合“charge”的词源语义,遵循语言翻译的忠实严谨原则,宜将“floating charge”译为“浮动担保”而非“浮动抵押”。至于浮动担保何去何从,相对合理的方案是将其嵌入合同法域,规定于我国民法典合同编之“合同的担保”章节,以此彰显民法典的体系性与逻辑性。     

新冠肺炎疫情期间公安法医应当加强尸体甄别和个体防护

因鉴定体制特点,公安法医除参与尸体有关的现场勘查工作外,还需进行尸体检验工作。在此过程中,可能面对很多风险,受伤和中毒等事件时有发生。然而,国内公安法医对新冠肺炎等传染病流行期间死亡的尸体如何甄别进行尸体检验鉴定,对现场勘查及尸体检验工作的防护只有少量规定,且内容不够详尽。本文对法医在现场勘查中遇到的尸体及尸体检验中实验室建设、职业现状、风险评估及防范措施等进行了论述。最后,建议出台相关的制度规定等具体约束规范措施,以保障公安法医现场勘查及尸体检验工作的顺利进行,以解除基层鉴定机构和鉴定人的后顾之忧。     

骨龄自动化评估的研究进展

骨龄是反映人体生长发育的一项重要指标,能够较为客观地反映个体生长发育水平及成熟度。传统的人工骨龄评估通常是将左手腕X线片与参考标准进行比较,从而获得相应的骨龄值,该方法既耗时又存在观察者间的差异。近年来,随着计算机科学的不断发展,促使骨龄评估开始由传统的人工评估向自动化评估转变。虽然骨龄自动化评估的研究已相当多,但大部分仍处于实验阶段。本文综述了近年来国内外学者在骨龄自动化评估方面的相关研究与进展,以期为相关研究人员提供参考与研究思路。     

Investigating Sales Tax Revenue Competition Among Principal Cities and Their Neighboring Cities in Texas

ABSTRACT

While research has explored the economic importance of principal cities on regional economies, little is known about the short-run and long-run dynamic relationships between principal cities and their neighboring cities as it pertains to their sales tax revenue elasticities and the subsequent affect this has on horizontal tax competition. Using vector error correction models on data from six principal cities in Texas, the findings of this study suggest that the relationship between principal and neighboring cities is highly dynamic and unique for each principal city. The study recommends that local economic policies should reflect these unique relationships.     

Shaking off the neoliberal shackles: “democratic emergence” and the negotiation of democratic knowledge in the Middle East North Africa context

ABSTRACT

There is a general assumption in democracy promotion that liberal democracy is the panacea that will solve all political and economic problems faced by developing countries. Using the concept of “good society” as analytical prism, the analysis shows that while there is a rhetorical agreement as to what the “good society” entails, democracy promotion practices fail to allow for recipients’ inclusion in the negotiation and delivery of the “good society”. Contrasting US and Tunisian discourses on the “good society”, the article argues that democracy promotion practices are underpinned by neoliberal parameters borne out from a reliance on the transition paradigm, which in turn leave little room to democracy promotion recipients to formulate knowledge claims supporting the emergence of alternative conceptions of the “good society”. In contrast, the article opens up a reflective pathway to a negotiated democratic knowledge, which would reside in a paradigmatic change that consists in the abandonment of the transition paradigm in favour of a “democratic emergence” paradigm.     

Mary Wollstonecraft’s divergent attitudes towards trust

ABSTRACT

Mary Wollstonecraft is increasingly being recognized as a philosopher who made a noteworthy contribution to moral and political philosophy. Her work not only encompassed political treatises, such as the now well-known A Vindication of the Rights of Woman, but also fiction. This article demonstrates how Wollstonecraft’s work comprised three main ways of engaging with trust, namely distrust, virtuous trust, and open trust. It puts these three forms of trust into context with Wollstonecraft’s ambivalent relation to the 18^th-century culture of sensibility. Moreover, Wollstonecraft’s open form of trust is compared with the 20^th-century Danish theologian and philosopher K. E. Løgstrup’s conception of trust. Løgstrup regarded genuine trust as a spontaneous, basic phenomenon that was not rooted in moral reasoning. While there are some similarities between Wollstonecraft’s open trust and Løgstrup’s understanding of trust, Wollstonecraft ultimately reinforced the value of ‘an educated heart’, namely the idea that the feelings of the heart should be cultivated by reason. Accordingly, this article offers some insight into how we may perceive Wollstonecraft’s strong rejection of Edmund Burke’s ‘inbred sentiments’, that is, Burke’s belief in innate, benign moral instincts.