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A qualitative and quantitative analytical method was developed and validated for the determination of 49 licit and illicit drugs in oral fluid. Small oral fluid samples, volume 1mL, were collected from volunteers using a modified Omni-Sal device and the analytes were extracted from an oral fluid/buffer mixture using a single Bond Elut Certify solid phase extraction cartridge. Liquid chromatography-tandem mass spectrometry (LC-MS-MS) and gas chromatography-repetitive full scan mass spectrometry (GC-MS) were used in parallel to analyze the extracts for the targeted drugs. Extracts were analyzed by GC-MS in their underivatized form and as their pentafluoropropionyl derivatives. Deuterated internal standards were used for quantification of drugs of abuse by LC-MS-MS to minimize matrix effects. Methadone-d(9) and tumoxetine were used as the internal standards for quantification of non-derivatized and derivatized analytes respectively by GC-MS. Linearity was demonstrated over the range 5-200 ng/mL and limits of detection were less than 4 ng/mL for each drug analyzed. The method demonstrated acceptable recoveries for most of the analytes and good intra- and inter-day precision. Acquisition of data by repetitive full scan GC-MS allows the addition of further analytes to the target menu.  相似文献   
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Allele frequencies for 18 STR autosomal loci (D3S1358, VWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, D16S539, TH01, TPOX, CSF1PO, Penta D, Penta E, D19S433, D2S1338 and SE33) were obtained from a sample of 191-500 unrelated individuals from Costa Rica, Central America.  相似文献   
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Fourier-transform infrared spectroscopy (FTIR), discriminate analysis, X-ray fluorescence spectrometry (XRF), and stereoscopic microscopy were used to separate black coral forensic evidence items from similarly appearing items manufactured from plastics, bovid keratin, and mangrove wood. In addition, novel observations were made of bromine and iodine relationships in black coral that have not been previously reported.  相似文献   
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School bullying incidents, particularly experiences with victimization, are a significant social and health concern among adolescents. The current study extended past research by examining the daily peer victimization experiences of Mexican-American adolescents and examining how chronic (mean-level) and episodic (daily-level) victimization incidents at school are associated with psychosocial, physical and school adjustment. Across a two-week span, 428 ninth and tenth grade Mexican-American students (51 % female) completed brief checklists every night before going to bed. Hierarchical linear model analyses revealed that, at the individual level, Mexican-American adolescents’ who reported more chronic peer victimization incidents across the two-weeks also reported heightened distress and academic problems. After accounting for adolescent’s mean levels of peer victimization, daily victimization incidents were associated with more school adjustment problems (i.e., academic problems, perceived role fulfillment as a good student). Additionally, support was found for the mediation model in which distress accounts for the mean-level association between peer victimization and academic problems. The results from the current study revealed that everyday peer victimization experiences among Mexican-American high school students have negative implications for adolescents’ adjustment, across multiple domains.  相似文献   
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Gender symmetry in intimate partner violence (IPV) has come to light in research, stirring much controversy. Historically, there has been resistance toward re-conceptualizing the problem from a psychology-informed framework, rather than from functional sociological discourse. Issues in examining IPV, with consideration of typologies, male victimization, and female perpetration, are discussed. Reporting, outcomes, revictimization, and perceptions of male victims and female perpetrators are addressed. An argument is offered for increased focus on psychological science, including theory and data from clinical, couple, and family systems disciplines, in addressing partner violence. A framework is provided for integrated, effective, and accurate approaches to IPV in discourse, policy, and service.  相似文献   
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Mexico experienced the twentieth century’s first social revolution, a decade of struggle from which emerged a new political regime – a post-revolutionary authoritarian or single-party state one – with President Lázaro Cárdenas as leader by 1934. This post-revolutionary creation included organized labor and peasants, a strong interventionist state and a hegemonic party. Cárdenas’ U.S. counterpart, President Franklin D. Roosevelt, too, was leading dramatic ‘New Deal’ institutional and political revolution in the 1930s and 1940s that spawned a new order of expanded federal government, a renovated Democratic Party, and new movements and interest groups, notably, labor. Both nations featured the same major actors: the state, political parties, and organized labor. Both presidents calculated that preserving labor alliances was crucial for formation and legitimization of a new political order, for maintaining conditions conducive to private-sector investment and economic growth, and for political and economic crisis management. Labor’s growing role reshuffled corporatist alliances within and between international neighbors. This study places Mexico and the United States in comparative context in the early twentieth century and analyzes elite control and inclusion of organized labor in transformation of political landscapes in two different political regimes – a democratic one couched in an established constitution and a post-revolutionary authoritarian one born of a bloody upheaval.  相似文献   
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