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Increasing scientific knowledge demands technological breakthroughs beyond industrial innovation activity. Using this as a basic motivation for R&D collaboration between industry and big science, the paper reports a systematic approach to exploit the technological treasures embedded in experimental basic research. Based on a systematic technology breakdown and mapping of each technological trajectory with possible application areas, the method enables one to direct joint efforts on the most prominent research topics. Yet, to achieve this active partners are needed to enter the innovative conversion process to turn scientific ambitions into commercial products. Some industrial companies practicing active R&D strategy have realized this, and the paper outlines some cases where the product innovation, is not the only motivation to enter big science collaboration. Putting all this together, and knowing the severe financial and political pressures the major scientific research labs are facing, the paper defines the practical procedures needed to initiate the process which eventually leads to better technological return from fundamental research.  相似文献   
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