Political Liberalism. Neutrality and the Political

Abstract. The paper examines the current discussion in liberalism around the issue of the "neutrality" of the state. It scrutinizes the "political liberalism" defended by John Rawls and Charles Larmore and shows that the consequence of their approach is to evacuate the dimension of "the political" from the idea of a well-ordered society. By presenting the exclusions existing in their model of liberal society as the product of free agreement resulting from rational procedures, "political liberals" offer us a picture in which antagonism, violence and power have only disappeared because they have been made invisible. The consequence is to leave liberalism unable to conceptualize power and antagonism. The paper concludes that there cannot be such a thing as a "neutral justification of the neutrality of the state" (Larmore 1987) and that a pluralist perfectionist perspective like the one proposed by Joseph Raz offers a more adequate way to envisage the specificity of modern pluralist democracy.     

Profiling of illicit fentanyl using UHPLC-MS/MS

Methodology is presented for the profiling of fentanyl in seized drugs using ultra high performance liquid chromatography in combination with tandem mass spectrometry (UHPLC-MS/MS). Target analysis was performed for 40 fentanyl processing impurities, several of which are markers for a specific synthetic route (Siegfried or Janssen). For the separation of these solutes, an Acquity BEH C18 1.7 μm particle column (150 mm × 2.1 mm) with a binary 1% formic acid (pH 2.0)/acetonitrile gradient was used. For MS/MS detection, an atmospheric pressure positive electrospray source was employed with selected reaction monitoring (SRM). The coupling of the high separation power of UHPLC with the highly selective and sensitive detection of MS/MS is amenable to the determination of synthetic route and linking of drug seizures. The technology is also applicable to exhibits containing trace levels of fentanyl in the presence of significantly excess amounts of heroin and/or adulterants.     

Four new illicit cocaine impurities from the oxidation of crude cocaine base: formation and characterization of the diastereomeric 2,3-dihydroxy-3-phenylpropionylecgonine methyl esters from cis- and trans-cinnamoylcocaine

Four new impurities have recently been detected in the gas chromatographic signature profiles of many illicit cocaine hydrochloride exhibits. These impurities are only seen in exhibits that have been oxidized and are most prominent in samples that have been highly oxidized. Exhibits containing these compounds were subjected to gas and liquid chromatographic-mass spectrometric analyses to determine the identity of the impurities. These impurities were subsequently synthesized to verify their structures. Four diastereomeric diols formed from the oxidation of cis- and trans-cinnamoylcocaine were characterized by nuclear magnetic resonance spectrometry, mass spectrometry, and synthesis. Oxidation of cis-cinnamoylcocaine in neutral conditions yielded (2R,3R)-dihydroxy-3-phenylpropionylecgonine methyl ester and (2S,3S)-dihydroxy-3-phenylpropionylecgonine methyl ester, while trans-cinnamoylcocaine produced (2R,3S)-dihydroxy-3-phenylpropionylecgonine methyl ester and (2S,3R)-dihydroxy-3-phenylpropionylecgonine methyl ester. The recent appearance of these new impurities suggests that some illicit cocaine processors have modified their oxidation procedures of crude cocaine base for transformation into illicit refined cocaine hydrochloride.     

Le probléme des origines des Assemblées d'États: Réflexions méthodologiques à la lumière de l'histoire sud‐est européenne de l'institution

Summary

This paper examines the relations between republican and democratic forces in Restoration Spain. From the middle of the last century, republicanism was the political movement most clearly involved with the democratization of Spanish politics. After the collapse of the 1873 Republic, the republican movement went through a severe crisis which led to its fragmentation over issues both of principle (federalists against unitarists) and of practice (revolutionaries against reformists). Between 1873 and 1931 Spanish republicanism underwent a marked transformation. The old republicanism was characterized by the modes of political activity of the nineteenth century — the club, the committee, the masonic lodge. The new republicanism, on the other hand, emerged from the first decade of the present century clearly moving in the direction of the modern political parties which finally crystallized out in 1931. Together the Radical and the Reformist parties are a case‐study in the transition between the classical and the modern which perfectly exemplifies the hybrid nature of republican democracy.

Though Spanish republicanism was socially heterogeneous, embracing within its various parts elements of the upper and middle bourgeoisie, substantial sections of the petty, urban bourgeoisie, and a declining, but still numerous, section of the working class, it still needed an alliance with the socialists (the Conjunción of 1910). However, what was most notable about Spanish republicanism was its link with the intelligentsia; it was they who gave it its character and who made the greatest effort to integrate Spain into the most modern currents of European thought.