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Managing incidental findings in human subjects research: analysis and recommendations. 总被引:8,自引:8,他引:0
Susan M Wolf Frances P Lawrenz Charles A Nelson Jeffrey P Kahn Mildred K Cho Ellen Wright Clayton Joel G Fletcher Michael K Georgieff Dale Hammerschmidt Kathy Hudson Judy Illes Vivek Kapur Moira A Keane Barbara A Koenig Bonnie S Leroy Elizabeth G McFarland Jordan Paradise Lisa S Parker Sharon F Terry Brian Van Ness Benjamin S Wilfond 《The Journal of law, medicine & ethics》2008,36(2):219-48, 211
No consensus yet exists on how to handle incidental findings (IFs) in human subjects research. Yet empirical studies document IFs in a wide range of research studies, where IFs are findings beyond the aims of the study that are of potential health or reproductive importance to the individual research participant. This paper reports recommendations of a two-year project group funded by NIH to study how to manage IFs in genetic and genomic research, as well as imaging research. We conclude that researchers have an obligation to address the possibility of discovering IFs in their protocol and communications with the IRB, and in their consent forms and communications with research participants. Researchers should establish a pathway for handling IFs and communicate that to the IRB and research participants. We recommend a pathway and categorize IFs into those that must be disclosed to research participants, those that may be disclosed, and those that should not be disclosed. 相似文献
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Gender and Feminism in the Social Sciences 总被引:1,自引:0,他引:1
AbstractFeminist scholarship has been central to the success and prominence of the Australian social sciences. The impact and significance of the work of sociologists such as Raewyn Connell and Rosemary Pringle, historians Barbara Caine and Marilyn Lake, philosophers Genevieve Lloyd and Moira Gatens and political scientists Carol Bacchi and Louise Chappell are recognised internationally. But how effective has feminist critique been in reshaping what counts as authoritative knowledge and research excellence in the disciplines? And what is the relationship between the disciplines' varying incorporation of feminist perspectives and their progress towards organisational gender equity goals? 相似文献
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Nancy Rumbaugh Whitesell Nancy L. Asdigian Carol E. Kaufman Cecelia Big Crow Carly Shangreau Ellen M. Keane Alicia C. Mousseau Christina M. Mitchell 《Journal of youth and adolescence》2014,43(3):437-453
Substance use often begins earlier among American Indians compared to the rest of the United States, a troubling reality that puts Native youth at risk for escalating and problematic use. We need to understand more fully patterns of emergent substance use among young American Indian adolescents, risk factors associated with escalating use trajectories, and protective factors that can be parlayed into robust prevention strategies. We used growth mixture modeling with longitudinal data from middle-school students on a Northern Plains reservation (Wave 1 N = 381, M age at baseline = 12.77, 45.6 % female) to identify subgroups exhibiting different trajectories of cigarette, alcohol, and marijuana use. We explored how both risk (e.g., exposure to stressful events, deviant peers) and protective (e.g., positive parent–child relationships, cultural identity) factors were related to these trajectories. For all substances, most youth showed trajectories characterized by low rates of substance use (nonuser classes), but many also showed patterns characterized by high and/or escalating use. Across substances, exposure to stress, early puberty, and deviant peer relationships were associated with the more problematic patterns, while strong relationships with parents and prosocial peers were associated with nonuser classes. Our measures of emergent cultural identity were generally unrelated to substance use trajectory classes among these young adolescents. The findings point to the importance of early substance use prevention programs for American Indian youth that attenuate the impact of exposure to stressful events, redirect peer relationships, and foster positive parent influences. They also point to the need to explore more fully how cultural influences can be captured. 相似文献
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The issue of ‘alcohol-fuelled violence’ has been the subject of intense policy debate in Australia. While this debate is warranted, its contours and content have been informed and shaped by a surprisingly narrow range of research resources. Narrow research engagements of this kind warrant scrutiny because they can exclude from consideration crucial issues. In this article we identify one such issue, that of gender. Following a review of the Australian literature on gender, alcohol and violence, our analysis explores four case studies drawn from the Australian research corpus, focusing on large quantitative studies as these tend to receive most attention and citation in policy debate. Such studies consistently erase the contribution of key gender dynamics, namely enactments of particular (often youthful) masculinities, to violence involving alcohol, even where they simultaneously provide strong support in their data for such a conclusion. We show how this research is mobilised specifically in support of claims about the causal role of alcohol in violence and of blanket population-level responses to the problem. There is an urgent need to map the character and scope of the tendency to erase certain gender issues in research on alcohol and violence in order to better inform policy responses. 相似文献
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