Beyond the Rails

The inauguration of the railway be-tween China and Laos is a key milestone in the realization of the Pan-Asian Railway Network running between Kunming, capital of Yunnan Province in southwest China, and Singapore.     

NEW DIMENSIONS

The active involvement of China in UN peacekeeping operations in the past three decades has earned it the status of global peace provider. Ever since China first deployed troops to the UN's blue helmets in 1990, when it sent five military observers to the Middle East, its commitment to serving the wellbeing of humanity through UN peacekeeping remains a key initiative showcasing the country's soft power.     

RCEP: Building Bridges,Not Walls

The parliamentary ratification of the Regional Comprehensive Economic Partnership (RCEP) agreement by 10 signatory states has finally set the world's biggest ever free trade bloc into motion, albeit only among the ratifying na-tions, on January 1, 2022. Six Association of Southeast Asian Nations (ASEAN) member states, namely Brunei, Cambodia, Laos, Singapore, Thailand and Viet Nam, as well as Australia, China, Japan and New Zealand, have completed the ratification procedures. The RCEP was also signed by another four ASEAN members, namely Indonesia, Malaysia, Myanmar and the Philippines, as well as the Republic of Korea (ROK). Once in full effect, it will cover approximately 30 percent of the world's population and one third of global GDP. The agreement manifests the firm commitment of all 15 signatory economies in the Asia-Pacific region to upholding an open, inclusive and rules-based multilateral trading system. Its implementation is particularly timely for the region as its economies struggle to recover from the impacts of COVID-19 and rising trends of de-globalization.     

Haplotype diversity of 16 Y-chromosomal STRs in three main ethnic populations (Malays, Chinese and Indians) in Malaysia

We have analyzed 16 Y-STR loci (DYS456, DYS389I, DYS390, DYS389II, DYS458, DYS19, DYS385a/b, DYS393, DYS391, DYS439, DYS635 or Y-GATA C4, DYS392, Y-GATA H4, DYS437, DYS438 and DYS448) from the non-recombining region of the human Y-chromosome in 980 male individuals from three main ethnic populations in Malaysia (Malay, Chinese, Indian) using the AmpFlSTR((R)) Y-filertrade mark (Applied Biosystems, Foster City, CA). The observed 17-loci haplotypes and the individual allele frequencies for each locus were estimated, whilst the locus diversity, haplotype diversity and discrimination capacity were calculated in the three ethnic populations. Analysis of molecular variance indicated that 88.7% of the haplotypic variation is found within population and 11.3% is between populations (fixation index F(ST)=0.113, p=0.000). This study has revealed Y-chromosomes with null alleles at several Y-loci, namely DYS458, DYS392, DYS389I, DYS389II, DYS439, DYS448 and Y-GATA H4; and several occurrences of duplications at the highly polymorphic DYS385 loci. Some of these deleted loci were in regions of the Y(q) arm that have been implicated in the occurrence of male infertility.     

Working Toward an Inclusive World

正The world has never been homogenous.Over the ages,the plurality of man has been blamed as the root of various conflicts.But it must also be acknowledged that it is through such diversity that mankind managed to compete and progress,ultimately contributing to what it is today.     

A distinct Y-STR haplotype for Amelogenin negative males characterized by a large Y(p)11.2 (DYS458-MSY1-AMEL-Y) deletion

The use of STR multiplexes with the incorporated gender marker Amelogenin is common practice in forensic DNA analysis. However, when a known male sample shows a dropout of the Amelogenin Y-allele, the STR system falsely genotypes it as a female. To date, our laboratory has observed 18 such cases: 12 from our Y-STR database and six from casework. A study on 980 male individuals in the Malaysian population using the AmpFlSTR Y-filer has revealed a distinct Y-chromosome haplotype associated with the Amelogenin nulls. Our results showed that whilst the Amelogenin nulls were noticeably absent among the Chinese, both the Indians and Malays exhibited such mutations at 3.2 and 0.6%, respectively. It was also found that the Amelogenin negative individuals predominantly belonged to the J2e lineage, suggesting the possibility of a common ancestor for at least some of these chromosomes. The null frequencies showed concordance with the data published in Chang et al. [Higher failures of Amelogenin sex test in an Indian population group, J. Forensic Sci. 48 (2003) 1309-1313] on a smaller Malaysian population of 338 males which used a Y-STR triplex. In the current study, apart from the absence of the Amelogenin Y-locus, a complete absence of the DYS458 locus in all the nulls was also observed. This study together with the 2003 study has indicated a similar deletion region exists on the Y(p)11.2 band in all the 18 Y-chromosomes. Using bioinformatics, this deletion has been mapped to a region of at least 1.13 Mb on the Y(p)11.2 encompassing the Amelogenin, MSY1 minisatellite and DYS458 locus. Further, the Y-filer haplotypes revealed an additional null at Y-GATA H4 in two of the Indian males presented here.     

Is an Ideological Clash a Self-Fulfilling Prophecy?

正Amid the recurrence of the COVID-19contagion across the globe,prospects for forging coordinated and coherent multilateral cooperation remain abysmal.While the blame game over the virus origin still rages on,a new dimension of schism along ideological seams is becoming increasingly pronounced.Jingoistic drum beats accompanying abrasive geopolitical rhetoric have been gaining traction at the expense of international cooperation.     

Anti-Terror In a Tangle?

This year marks the 20th anniversary of the September 11 terrorist attacks that triggered the American "war on terror," a blanket term for all preemptive military strikes intended to reduce the threat terrorism posed to the U.S. homeland. It was foreshadowed by the U.S. invasion of Afghanistan in October 2001, which had brought about enormous sorrow, wanton destruction and civilian casualties to the Afghan nation before the American troops finally made their chaotic exit two decades later.