High performance liquid chromatographic determination of alcohols with reference to body distribution of methanol

A method has been developed on reverse phase high performance liquid chromatography for simultaneous determination of methyl, ethyl and isopropyl alcohols under refractive index detection using pure water as the mobile phase. A good separation has been achieved between these alcohols. Detector response was linear with a detection limit of 5 mg/100 ml. Recovery studies were performed by adding known amounts of methyl and ethyl alcohols to blood, lung and liver within the range 80–90%. The reproducibility of the results was always >90%. The quantitative distribution of methyl alcohol in postmortem body tissues and fluids has been reported in three cases of poisoning.     

Dangerousness of the delusional misidentification of children.

Misidentification syndromes have been studied from a variety of perspectives, including phenomenological, biological, and nosological approaches. More recently, misidentification syndromes have been studied from a psychiatric-legal perspective, especially with regards to the problem of dangerousness. Capgras syndrome and other syndromes of misidentification can lead to hostile mood and subsequent physical violence. Little attention has so far been devoted to children as the objects of the psychotic person's misidentification delusion(s). We provide a review of cases from the anglophonic literature that have children as the misidentified objects, add three new cases, and then discuss the relationship between misidentification and potential harm to these children.     

Consequences and dilemmas in therapeutic relationships with families resulting from mandatory reporting legislation

Mandatory reporting legislation has been adopted in every state to insure the protection of children from maltreatment. These statutes have become a significant factor in the lives of mental health professionals who work with children and families. Thirty psychotherapists who had made a recent report of child maltreatment on a client in treatment were interviewed about their experiences with reporting and the consequences of reporting for therapeutic relationships. Several potentially problematic consequences and dilemmas were identified by the therapists, including immediate and long-term effects on the therapeutic alliance and course of therapy, and conflicts of interest in working with children and families.     

From IDA to IIROC: Has self-regulation in the Canadian investment industry evolved?

This article analyzes the enforcement practices of the Investment Industry Regulatory Organization of Canada (IIROC) and compares them with its predecessor, the Investment Dealers Association of Canada (IDA). The study collected data from IIROC's tribunal cases decided between June 2008 and December 2019 and compared them with data on the IDA's enforcement of complaints from 1984 to 2008. The findings reveal no statistically significant difference in the fines imposed by the two regulatory bodies. Furthermore, IIROC has refrained from issuing lenient penalties such as retaking examinations/courses or mandating terms and conditions for offenders. The results also indicate no significant impact on the number or distribution of offense types committed in the industry over time. Most notably, the Ontario Securities Commission, the Canadian Securities Regulators, and the new Self-Regulatory Organization of Canada should consider these findings when formulating policies concerning the role of self-regulation in the financial markets.     

尼泊尔的灾害管理体制

地理环境尼泊尔位于北纬26.220—30.270,东经80.040—88.120,国土面积为147181平方公里,主要位于喜玛拉雅山脉南坡。尼泊尔东西南面与印度接壤,北临中国。尼泊尔的人口约为2300万,人口年增长率为2.3%。分为5个行政区域,14个地区,75个小区,58个城市,3913个村委会。人口分布为南部平原集中,北部地区稀少。53%人口接受过普通教育。尼泊尔一般分为三个部分:Himalaya、Mid-hill和Terai地区。由于地理位置不同,尼泊尔的气候特征也不同。尼泊尔虽然面积小,但是却遭受多种自然灾害的侵袭。主要的灾害有地震、洪水、山体滑坡、泥石流、雪崩、森林火…     

Impact of patent rights on innovation: A meta‐analysis

Research shows that the enforcement of patent rights (PRs) play a significant role in countries' innovation and technological development. The existing narrative reviews find that the impact of PRs on innovation is not clear across countries. Therefore, this study examines the impact of patent rights protection on innovation across countries by conducting a meta‐analysis from 14 empirical studies that contain 145 estimates, undertaken during 1996–2019. This study intends to test whether the findings are sensitive to various measures employed and identify possible policy implications across countries. Our analysis suggests that certain aspects of measuring innovation are crucial in explaining the significance of these findings. This study finds that countries' strength in PRs plays a significant role in determining its innovation. We also find that there is a distinction in PRs' contribution to domestic innovation across developed and developing countries in the existing primary studies.     

Cerebrospinal fluid analysis in fatal thallium poisoning: evidence for delayed distribution into the central nervous system

The neurologic manifestations of thallium poisoning include a severely painful ascending peripheral neuropathy, autonomic dysfunction, cranial nerve abnormalities, and a toxic encephalopathy. Although thallium has a short half-life, these neurologic manifestations commonly progress, even as the blood concentration of thallium decreases. This suggests either that thallium persists in neuronal tissues or that it initiates an injury cascade that takes time to fully manifest. As the latter mechanism is consistent with many toxin exposures, the concept of a central nervous system reservoir for thallium is often discounted. A recent case provided a unique opportunity to evaluate this possibility. A 48-year-old man was acutely and chronically thallium poisoned by his common-law wife. During his initial exposures, only gastrointestinal symptoms manifested. Following an acute ingestion, hospitalization was required. Over 3 days, his symptoms rapidly progressed from a severely painful neuropathy to slurred speech, ptosis, confusion, coma, respiratory insufficiency, and death. Because of considerations of alternative diagnoses, 2 lumbar punctures were performed, one on admission and another on the day of his death. Serum thallium concentrations obtained from stored blood samples were paired with spinal fluid concentrations from the same days. On day 1, serum and spinal fluid concentrations were 8700 mu/L and 1200 mu/L, respectively. On day 3, although the serum concentration had fallen to 7200 mu/L, the spinal fluid concentration had increased to 2100 mu/L. This case provides evidence to support the hypothesis that thallium distributes into the central nervous system more slowly than the blood compartment, and this may in part account for the progression of neurologic findings in the setting of decreasing serum concentrations.     

The Youth Panorama of Northeast India

The article focuses on youth in Northeast India, particularly its youth panorama by tracing its history as well as the present. Northeast India was one of the last areas to be taken over by the British on the subcontinent. Most of its states share an international border. With 213 tribal communities, 175 languages and many non-tribal communities, the region presents a unique cultural, ethnic, linguistic and religious profile not to be found in any other region in India.     

The Meitei upsurge in Manipur

This article traces the rise of militancy in Manipur including the Armed Forces Special Powers Act 1958 (AFSPA) and analyses the reasons and its impact on the people. Manipur is one of the Indian states plagued by self-determination movement, inter-ethnic strife, and the militarization of ethnic groups for the last few decades. The Indian Armed Forces, who are specially trained to protect the country against a foreign invasion, are being engaged to combat internal strife with extraordinary powers. This has further worsened the conditions in the state. In the period of 1980 to May 30, 2007, 2,675 civilians and 1,314 militants were killed; while 2,061 civilians were injured and only 865 militants surrendered to the authorities. It can be said that five decades of conflict have greatly undermined the people of Manipur, both physically and spiritually and have threatened the very survival of entire communities.

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