Complex chemical and toxicological analysis of prosidol

Methods for measuring a Russian narcotic analgesic prosidol are suggested: thin-layer chromatography, microcrystalloscopy, gaseous chromatography with ionization flame detector, gas chromatography with mass selective detector, ultraviolet spectroscopy, high-performance liquid chromatography with ultraviolet detector, proton nuclear magnetic resonance used in chemical toxicological analysis, pharmacological analysis, and investigation of material evidence pieces.     

Detection of cannabinoids in urine

Described in the paper are results of comparative examination of urine by the methods of immunochromatographic express analysis (ICA), fluorescence-polarization immune analysis (FIA) and of thin-layer chromatography (TLC) made for the purpose of detecting consumers of hemp products. A high specificity and a good sensitivity of the methods were demonstrated, which is a basis for using them as preliminary tests in detecting cannaboids and their metabolites in urine. The methods were evaluated quantitively and qualitatively versus the etalon method of chromato-mass-spectrometry. A possibility was pointed out to apply the methods of ICA and TLC as system analysis in the determination of 11-nordelta-9-tetrahydrocannabinol-9-carbonic acid in urine of marijuana users.     

Chemical toxicological analysis of urinary cannabinoids by chromatography mass spectrometry

A chromato-mass-spectrometric method for identification of cannabinoids and 9-carboxy-11-nor-delta 9-tetrahydrocannabinol by their methyl derivatives is proposed. Use of alkaline hydrolysis in pretreatment of samples ensures the optimal conditions for complete isolation of 9-carboxy-11-nor-delta 9-tetrahydrocannabinol. Derivation with methyl iodide in absolute acetone in the presence of potassium carbonate was used. Preliminary conclusion on the presence of cannabinoids in the urine can be made from the results of enzyme immunoassay.     

Modeling Risk for Intimate Partner Violence among Recent-Era Veteran-Partner Dyads

Using an actor-partner interdependence model, we examined whether veterans’ posttraumatic stress symptoms (PTSS) contributed to partners’ drug abuse symptoms, whether partners’ drug abuse symptoms contributed to intimate partner violence (IPV) perpetration, and whether drug abuse symptoms mediated PTSS-IPV perpetration associations. Participants were recent-era veterans who participated in the Mid-Atlantic Mental Illness Research, Education and Clinical Center Post-Deployment Mental Health study. Veterans who took part at one site and their partners (N = 49 couples) completed a follow-up study in which drug abuse symptoms and IPV perpetration were assessed. Veterans’ PTSS contributed to veterans’ drug abuse symptoms. Veterans’ drug abuse symptoms were associated with their IPV perpetration (i.e., an actor effect) and their partners’ IPV perpetration (i.e., a crossover effect). Drug abuse symptoms mediated the association between veterans’ PTSS and partners’ reports of IPV perpetration. Findings suggest complex relationships between PTSS, drug abuse problems and IPV perpetration among these dyads.