Cross-reactivities of various phenethylamine-type designer drugs to immunoassays for amphetamines, with special attention to the evaluation of the one-step urine drug test Instant-View™, and the Emit® assays for use in drug enforcement

Cross-reactivities of 76 kinds of phenethylamine-type designer drugs and related compounds to the urine drug tests Instant-View ? (IV) (the Methamphetamine (MA) test, the Amphetamine 300 test, and the MDMA test) have been investigated. An on-site urine test kit consisting of these three IV tests has been evaluated for the on-site screening of MA users, and the kit has been found to have satisfactory specificity for drug enforcement purposes by separately detecting both MA and its metabolite amphetamine. The cross-reactivity profiles of Emit(?) II Plus Amphetamines Assay, Emit(?) II Plus Ecstasy assay, and Emit(?) d.a.u.(?) Amphetamine Class assay have also been investigated and discussed.     

Long-term stability of various drugs and metabolites in urine, and preventive measures against their decomposition with special attention to filtration sterilization

The long-term stability of drugs and metabolites of forensic interest in urine, and preventive measures against their decomposition have been investigated, with special attention to filtration sterilization. An aseptic urine collection kit, which was recently developed based on filtration sterilization, was utilized for the aseptic collection and storage of urine samples. For evaluating preservation measures, methamphetamine (MA), amphetamine (AP), nitrazepam (NZ), estazolam (EZ), 7-aminoflunitrazepam (7AF), cocaine (COC), and 6-acetylmorphine (6AM) were spiked into urine at 500 ng/mL each, and were monitored for 6 months at 25, 4, and -20 degrees C, after the addition of NaN(3) and/or filtration sterilization using the aseptic collection kit. In severely contaminated urine with bacteria, there were significant losses of 7AF and NZ, and slight decomposition of MA and AP at 25 degrees C. However, such degradation was successfully suppressed by the use of the kit, though the use of the kit and NaN(3) were preferred for 7AF. The kit was also effective in preventing the hydrolyses of COC and 6AM, while it was suggested that the common preservative NaN(3) can accelerate the hydrolysis of such ester-type drugs and metabolites.     

Sharing the Burden: The Role of Government and NGOs in Protecting and Providing for Asylum Seekers and Refugees in Japan

This article examines the background to Japan's current refugeerecognition and protection regime in the thematic context ofburden-sharing. It considers recent legislative reforms andthe role of local NGOs with the aim of setting Japan's domesticprotection framework against the background of its internationallegal obligations. The analysis suggests that the policy andpractices of the Japanese government have resulted in the exclusionof many who seek to enter the country and that for those in-countrythere is inadequate state social and welfare provision. Thearticle questions whether Japan's significant financial contributioncan adequately discharge its international burden-sharing responsibilitiesand argues that the government has effectively shifted responsibilityfor protection and support to local NGOs. It concludes thatwithout further changes burden-shifting and not burden-sharingwill remain a predominant feature of Japan's approach to protectingand providing for asylum seekers and refugees in Japan.     

Source Cues, Partisan Identities, and Political Value Expression

This article examines the conditions under which partisan identities shape the positions people express on four political values: equal opportunity, self-reliance, moral traditionalism, and moral tolerance. The theoretical framework posits that (1) party source cues activate latent partisan biases in the minds of citizens, which in turn affect the degree to which individuals express support for these values; (2) out-party cues are more powerful motivators of value expression than in-party cues; (3) value shifts are more pronounced when liberal-conservative identities reinforce partisan sentiments; and (4) partisan cues promote horizontal constraint among these values. These hypotheses are tested using data from a set of experiments appearing on a novel national survey. The empirical results generally support these theoretical expectations.     

Virtual Civil Society: The New Frontier of Social Capital?

Although many scholars agree that social interactions within traditional social groups build social capital, there is less consensus on the benefits of virtual interactions for political engagement. Our research examines how interpersonal social group activity and virtual activity contribute to two dimensions of social capital: citizen norms and political involvement. We rely on data collected in the 2005 Citizenship Involvement in Democracy survey conducted by the Center for Democracy and Civil Society at Georgetown University. This survey provides unique detail on participation in both social groups and virtual interactions. Our findings suggest that social group activity and virtual interactions both foster many of the same positive aspects of social capital.     

Urinary endogenous concentrations of GHB and its isomers in healthy humans and diabetics

Urinary endogenous concentrations of gamma-hydroxybutyric acid (GHB), alpha-hydroxybutyric acid (AHB) and beta-hydroxybutyric acid (BHB) have been investigated for both healthy humans and diabetics by using a newly optimized GC-MS procedure. The endogenous concentrations in healthy volunteers' urine ranged 0.16-2.14 microg/ml for GHB, 0.10-2.68 microg/ml for AHB and 8.51-34.7 microg/ml for BHB. In diabetics, the concentrations ranged 0.17-3.03 microg/ml for GHB, 0.14-124 microg/ml for AHB and 4.94-4520 microg/ml for BHB. Although notably elevated BHB and AHB concentrations were observed for severely uncontrolled diabetics, their GHB concentrations ranged within or near the range seen in healthy humans. The results of this study confirm the previously suggested 10 microg/ml cutoff concentration of urinary GHB to distinguish exogenous GHB, even for uncontrolled diabetic patients suffering severe ketoacidosis.     

Public Nursery School Costs and the Effects of the Funding Reforms in Japan

Using a panel dataset of 983 municipalities across Japan, this article investigates the impact of the funding reforms in 2004 on public nursery schools’ operating costs. We found that municipalities responded differently to the reforms, depending on their fiscal strength and city scale. In areas with relatively large populations, fiscally stronger municipalities were likely to spend less on public nursery schools in the wake of the reforms, while municipalities in smaller cities spent more. Besides, municipalities that were not compensated for the loss of the national subsidy reduced expenditures in large cities. In small cities, on the other hand, such municipalities actually increased expenditures.