Destruction of intracerebrally applied red blood cells in cervical lymph nodes. Experimental investigations

In rabbits, intracerebrally applied erythrocytes can move with the cerebrospinal fluid along connecting pathways between the subarachnoid space and the cervical lymph nodes. This study compares the time dependency for the degradation of intracerebrally injected erythrocytes in the brain as well as in the cervical lymph nodes. Rabbits were killed at various predetermined intervals after the intracerebral erythrocyte injection. Microscopic and histologic examination of the brain and the cervical lymph nodes revealed the following findings: (1) Erythrophages first appeared in the brain 24 h after the injection; siderophages, 4 days after the injection. Siderophages were still demonstrable at the conclusion of the study, i.e. 240 days after the injection. (2) In the cervical lymph nodes erythrophages were first observed 1 h after the injection; siderophages, 9 h after the injection. Only isolated erythrophages and siderophages were found in the lymph nodes 12 days after intracerebral injection of red blood cells. Later on no erythrocytes or siderophages were observed in the lymph nodes. The findings indicate that non-phagocytized red blood cells arriving at the lymph nodes were ingested by local macrophages. The extremely rapid ingestion and digestion of the red blood cells by lymph node macrophages as well as the possible reasons were discussed.     

A Broad Alliance of Civil Society Organizations on Climate Change Mitigation: Political Strength or Legitimizing Support?

One hundred and one very different organizations joined together prior to the election for the Norwegian parliament in 2013 in order to make climate change mitigation the most important issue in the election campaign. The alliance (CE2013) agreed on six political demands relating to mitigation. In this article, we categorize the 101 organizations and discuss their identity and objectives according to these demands. The analysis demonstrates that even though a broad variety of organizations joined the campaign, their commitment was rather weak. Few of the organizations justify their involvement in CE2013 by all six political demands, hence demonstrating that climate change mitigation is a valence issue.