A mixed DNA profile controversy revisited

Semaan et al. (J Forensic Res, 2020, 11, 453) discuss a mock case “where eight different individuals [P₁ through P₈] could not be excluded in a mixed DNA analysis. Even though … expert DNA mixture analysis software was used.” Two of these are the true donors. The LRs reported are incorrect due to the incorrect entry of propositions into LRmix Studio. This forced the software to account for most of the alleles as drop-in, resulting in LRs 60–70 orders of magnitude larger than expected. P₁, P₂, P₄, P₅, and P₈ can be manually excluded using peak heights. This has relevance when using LRmix which does not use peak heights. We extend the work using the same two reference genotypes who were the true contributors as Semaan et al. (J Forensic Res, 2020, 11, 453). We simulate three two-donor mixtures with peak heights using these two genotypes and analyze using STRmix?. For the simulated 1:1 mixture, one of the non-donors’ LRs supported him being a contributor when no conditioning was used. When considered in combination with any other potential donors (i.e., with conditioning), this non-donor was correctly eliminated. For the 3:1 mixture, all results correctly supported that the non-donors were not contributors. The low-template 4:1 mixture LRs with no conditioning showed support for all eight profiles as donors. However, the results from pair-wise conditioning showed that only the two ground truth donors had LRs supporting that they were contributors to the mixture. We recommend the use of peak heights and conditioning profiles, as this allows better sensitivity and specificity even when the persons share many alleles.     

End of the Lone Wolf: The Typology that Should Not Have Been

This research note argues that the “lone wolf” typology should be fundamentally reconsidered. Based on a three-year empirical research project, two key points are made to support this argument. First, the authors found that ties to online and offline radical milieus are critical to lone actors' adoption and maintenance of both the motive and capability to commit acts of terrorism. Second, in terms of pre-attack behaviors, the majority of lone actors are not the stealthy and highly capable terrorists the “lone wolf” moniker alludes to. These findings not only urge a reconsideration of the utility of the lone-wolf concept, they are also particularly relevant for counterterrorism professionals, whose conceptions of this threat may have closed off avenues for detection and interdiction that do, in fact, exist.     

Stalinism and Executive Power: Formal and Informal Contours of Stalinism

Abstract

One of the key characteristics of Stalinism was the relationship between its formal and informal aspects. This is reflected clearly in the way in which, over time, the formal institutions of rule were supplanted by more informal mechanisms of decision-making. However, although the formal institutions seemed to atrophy, they were not abolished, but continued to become the basis upon which the post-Stalin leadership rested. The essay explains why one of those institutions, the Politburo, was maintained despite its atrophy as a decision-making organ, explaining this principally as a result of both strategic and tactical considerations.     

DNA commission of the International Society of Forensic Genetics: Recommendations on the interpretation of mixtures

The DNA commission of the International Society of Forensic Genetics (ISFG) was convened at the 21st congress of the International Society for Forensic Genetics held between 13 and 17 September in the Azores, Portugal. The purpose of the group was to agree on guidelines to encourage best practice that can be universally applied to assist with mixture interpretation. In addition the commission was tasked to provide guidance on low copy number (LCN) reporting. Our discussions have highlighted a significant need for continuing education and research into this area. We have attempted to present a consensus from experts but to be practical we do not claim to have conveyed a clear vision in every respect in this difficult subject. For this reason, we propose to allow a period of time for feedback and reflection by the scientific community. Then the DNA commission will meet again to consider further recommendations.     

A report of an international collaborative experiment to demonstrate the uniformity obtainable using DNA profiling techniques.

This paper describes a collaborative exercise intended to demonstrate whether uniformity of DNA profile results could be achieved between different European laboratories. It was shown that this goal can be obtained provided that a common protocol is followed (specifically the use of a common electrophoretic buffer as being the most important parameter). Generally, lower molecular weight loci (with lower molecular weight fragments) such as YNH24 perform better than higher molecular weight loci such as MS43a. The results of the exercise are discussed in relation to the objectives of the European DNA profiling group (EDNAP).     

EU Directive on unfair commercial practices--a UK perspective

Legal context. Lack of any catch-all law of unfair competitionin the UK – difficulty for brand owners in protectingtheir IP rights with regard to look-alike products. UK remediessuch as passing-off and trade mark infringement have provedtoo narrow. EU Directive will add to the remedies availableand may assist brand owners in their battle against look-a-likeproducts. Key points. Legal position on look-a-likes in the UK –objectives of the new Directive. Analysis of the two main waysto establish a commercial practice is unfair in the look-a-likecontext. The likely effect of the Directive in the UK on copycatsyndrome and looking to the future. Practical significance. Brand owners may use the new law alongwith the old to stamp out look-a-like activities. Practicalapplication of the test under the Directive. Remedies includecourt orders to stop and prevent unfair commercial practiceto optional possibility of court-imposed requirement to publisha corrective statement or fine – if latter is introducedinto the UK would be an additional deterrent factor of practicalvalue.     

Reviews

David W. Lovell, From Marx to Lenin. An Evaluation of Marx's Responsibility for Soviet Authoritarianism. London: Cambridge University Press, 1984, xii + 231 pp. £19–50.

A. J. Polan, Lenin and the End of Politics. London: Methuen, 1984, vi + 229 pp. h/b £12–95, p/b £5–95.

David Lane, State and Politics in the USSR. Oxford: Basil Blackwell, 1985, xv + 398 pp. h/b £27–50 p/b £8.95. Soviet Economy and Society. Oxford: Basil Blackwell, 1985, xiii + 342 pp. h/b £27–50 p/b £8.95.

Curtis Keeble, ed., The Soviet State. The Domestic Roots of Soviet Foreign Policy, London: Gower, 1985, 244 pp. h/b £17.50 p/b 8.95.

Adam B. Ulam, Dangerous Relations: The Soviet Union in World Politics, 1970–1982. New York: Oxford University Press, 1983 vi + 325 pp., £5–95.

Gerald Segal, ed., The Soviet Union in East Asia: Predicaments of Power. London: Heinemann, 1983. x + 150 pp., h/b £14–50 p/b £6–50.

Bruce D. Porter, The USSR in Third World Conflicts: Soviet Arms and Diplomacy in Local Wars 1945–1980. Cambridge, London, New York, New Rochelle, Melbourne, Sydney: Cambridge University Press, 1984, viii + 248 pp., £20–00, $29.95.

Robert L. Pfaltzgraff, Jr., and Uri Ra'anan, eds., National Security Policy. The Decision‐making Process, Hamden, Conn.: Archon Books, 1984, xiv + 311 pp. £35.30.

Yosef Avidar, The Party and the Army in the Soviet Union. Jerusalem: The Magnes Press, The Hebrew University, 1983, 340 pp., h/b $25.00.

William Moskoff, Labour and Leisure in the Soviet Union: The Conflict Between Public and Private Decision‐Making in a Planned Economy. New York: St. Martin's Press, 1984, xv + 225 pp., £25.00.

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Dina Kaminskaya, Final Judgement. My Life as a Soviet Defence Lawyer. London: Harvill Press, 1983, 364 pp., £12.95.

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Gabriel Gorodetsky, Stafford Cripps’ Mission to Moscow 1940–42, Cambridge: the University Press, 1984, 377 pp., £25.00.

E. H. Carr (Edited by Tamara Deutscher), The Comintern and the Spanish Civil War. London: Macmillan, 1984, xx + 111pp., h/b £17–50, p/b £6.95.

David Mandel, The Petrograd Workers and the Fall of the Old Regime: From the February Revolution to the July Days 1917. London: Macmillan, (in association with the Centre for Russian and East European Studies, University of Birmingham), 1983, xii + 210 + 10 pp., £25.00.

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Paul‐Gunther Schmidt, Internationale Wahrungspolitik im sozialistischen Staat, Stuttgart, New York: Gustav Fischer Verlag, 1985, xii + 447 pp., DM 48.

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Reviews

Stephen White, Alex Pravda & Zvi Gitelman, eds, Developments in Soviet Politics. London: Macmillan, 1990, xvii+310 pp., £35.00 h/b, £9.99, p/b.

Jiri Valenta & Frank Cibulka, eds, Gorbachev's New Thinking and Third World Conflicts. New Brunswick, NJ: Transaction Publishers, 1990, xxxiii+352 pp., $34.95, £25.95.

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International Organizations in Transfer of Infectious Diseases: Iterative Loops of Adoption, Adaptation, and Marketing

Over the past few years increasing attention has been given to the role of international organizations in the diffusion of policy ideas and promotion of particular macro-level policies. Much of the attention has been on the ideological driving forces behind such policies, and on the extent to which the policies are externally imposed. There has been limited discussion on the bread-and-butter, technical policies of international organizations, and how they devise, adopt, adapt, and then promote what come to be seen as policies of global "best practice." This paper seeks to redress this gap by looking at the process of transfer of two infectious disease policies between international and national levels. It demonstrates that international organizations play different roles in policy transfer at particular stages in the process. The paper suggests that health policy transfer is a long adaptive process, made up of several iterative loops, as research and clinical practices developed in one or more countries are adopted, adapted, and taken up by international organizations which then mobilize support for particular policies, market, and promote them. Assumptions that new ideas about policies flow "rationally" into existing decision making are challenged by the processes analyzed here. Policy transfer, given the experience of these infectious diseases policies, goes through separate, "bottom-up," research-oriented, and "top-down" marketing-oriented loops. Individuals and different configurations of networks play key roles linking these loops. In the process, complex, context-specific policies are repackaged into simplified guidelines for global best practice, leading to considerable contestation within the policy networks.