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1.
大鼠液压冲击脑损伤TGF-β1及其受体TβR I的表达 总被引:7,自引:1,他引:6
目的观察脑损伤后TGF-β1及其受体TβRI蛋白表达及其时序性变化,探讨脑损伤的分子机制及法医学脑损伤时间推断。方法用免疫组织化学方法观察大鼠液压冲击脑损伤后TGF-β1及其受体TβRI蛋白在伤后不同时间(30 min、1 h、3 h、6 h、12 h、1 d、3 d、7 d)的表达情况,以正常大鼠及手术大鼠作为对照。结果 (1)正常及手术对照组大鼠脑组织内有低水平的TGF-β1及TβRI表达;(2)脑损伤后1~3d,大脑皮质和脑干TGF-β1/TβRI蛋白表达逐渐增加,7 d时仍维持在高表达水平;(3)海马冲击后12 h~1 d逐渐增加,3 d时仍处于高表达水平,7 d时已开始下降。结论脑损伤可诱导TGF-β1/TβRI基因在脑内表达,其时序性改变可望用于法医学脑损伤时间推断。 相似文献
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Gonzalo Ordez‐Matamoros Michelle Vernot‐Lpez Ornella Moreno‐Mattar Luis Antonio Orozco 《政策研究评论》2020,37(2):174-200
International research collaboration (IRC) is associated with both positive and negative effects on the performance of research in emerging economies. While some authors claim that North–South collaborations improve scientific quality and visibility for Southern countries, others claim that it may entail the reorientation of research to comply with Northern agendas. South–South collaborations are thought to increase the focus on local affairs, therefore leading to a relatively small number of scientific international publications appearing in “high quality” journals. Research on the impact of IRC beyond publications in international journals has been neglected despite the importance of other products in knowledge creation. This research uses a broad range of scientific outputs to empirically assess such assumptions and explore the outcomes of IRC in Colombia. Results from multivariate regressions and nonparametric analyses show that, contrary to common assumptions, Colombian research teams collaborating with partners from the global South report higher scientific production, while those collaborating with Northern countries seem to contribute to local knowledge the most. 相似文献
4.
本文以迄今影响力最大的韩国凤山假面舞为研究对象,通过对凤山假面舞的演出形式特征,内容情节,假面的颜色、线条、表情等方面进行考察,运用文化功能理论,分析了凤山假面舞的社会功能和艺术价值。从而,揭示出韩国凤山假面舞具有宗教功能、调控功能、凝聚功能等社会功能和"寓褒贬,别善恶"的艺术特征。结论部分指出:凤山假面舞作为一种传统文化现象,它所具有的社会功能和艺术价值就是其传承发展的文化迫力,而韩国人充分认识到了传统文化的社会功能,这一点值得借鉴。 相似文献
5.
Debates concerning the taxation of prostitution have occurred in taxation law and in feminist literature. This article will integrate the case of Polok v. C.E.C. [2002] E.W.H.C, 156; [2002] S.T.C. 361, within the feminist legal canon. The case is discussed in the context of the argument of the European doctrine of fiscal neutrality, which dictates that, regardless of legality as amongst member states, if an activity is levied to V.A.T. in one member state, V.A.T. should be levied on it in all member states. The doctrine of sovereignty accepts the possibility that the integrity of the V.A.T. system may be compromised by the levying of tax on illegal activities, in terms of the cooperation between tax and other aspects of the U.K.’s legal system. European law, feminist law, commodification and the marketplace are all considered within the context of these principles. The article also considers the place of Polok within standard feminist texts on prostitution. Different paradigms of prostitution define different aspects of prostitution as ‘problems’, and the article considers the implications within a feminist reconstruction of Polok of this. The article suggests that the challenge for a feminist analysis of Polok is to remain within the realm of European tax and competition law, and to render the perspective of the employees of the Polok taxpayers part of the substance of the deliberations of the case. 相似文献
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陈平原对夏志清文学史写作的批评中强调文学史与文学批评的分界,这一提法反映了美学对于文学史家只是辅助手段的偏见。过分注重演化价值的文学史写法带来一些消极的影响,即强调科学、实证的研究思维,忽略了作品与艺术家个性的关系以及艺术作品里隐含的世界观问题。文学史家在建构宏阔的史学框架时应同时具备对作品的想象性理解,因而优秀的文学史家也是文学批评家。 相似文献
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Richard M. Jobin Denise Patterson Youfang Zhang 《Forensic Science International: Genetics Supplement Series》2008,2(3):190-197
The present study involves the development of forensic DNA typing tests and databases for mule deer in the Province of Alberta. Two multiplex PCR reactions interrogating 10 loci were used to analyze samples from three populations of mule deer. Additionally, an amelogenin based sex-typing marker was used to determine the gender of samples. Results show that the tests and databases are appropriate for use in forensic applications. Additionally, the results indicate that there is little population structure in mule deer in Alberta and that no changes to management of this game species are suggested. 相似文献
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随着测谎技术在司法工作领域内的广泛开展 ,解决了许多以往用经验、技术无法面对和解决的问题。从以往只由物的鉴识进而发展到对人的鉴识 ,避免了由于复杂的犯罪假象而带来的侦查活动的盲目性。作为一种侦查手段的测试结论 ,为测后审讯及审讯方案提供了事实上的依据。测试活动和测试结论的得出 ,改变了审讯活动中 ,敌我双方的力量和态势 ,是促成犯罪嫌疑人作出真实供述的重要基础。犯罪心理测试作为一种技术手段用于侦查阶段 ,是行之有效的。但它不能代替侦查、审讯 ,其结论最终是通过审讯查证所获取的证据来印证、核实。 相似文献
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唐宋处于中国封建文明史的转型时期,包括封建经济在内的社会生活的各个方面都发生了前所未有的深刻变化.与繁荣兴旺的商品经济相适应,唐宋政府的商业政策亦随之进行了调整.概而言之,主要是由专卖榷利制度向注重征商转变,商税逐渐制度化、规范化,扶商政策出现并付诸实施. 相似文献
10.
Jan Peter Andreas Kirchner Eberhard Kuhlisch Mario Menschikowski Bernhard Neef Jan Dreßler 《Forensic Science International Supplement Series》2006,160(2-3):127-133
The forensic diagnosis of cardiac contusion has hitherto been based mainly on anamnesis, concomitant thoracic injuries and the detection of macroscopic changes to the heart. Parallel histological and serological investigations of the heart-specific troponins have been conducted with varying results. This paper aims to show whether heart-specific troponins are suitable as a means of securing the diagnosis in proven cases of cardiac contusion and of determining which of the three heart-specific troponins cTnT, cTnI and cTnC are most significant in serology and histology for postmortem diagnosis.In the study, 25 cases of known cardiac contusion and 11 controls without vital myocardial trauma taken from autopsy material were prospectively investigated. Investigation of the venous serum revealed significant differences in the concentrations of the case and control groups for troponin T (mean value 5.5056 versus 0.4982; p = 0.014), for troponin C (mean value 263.9280 versus 68.5640; p = 0.001) and for troponin I (mean value 1404.0560 versus 36.1650; p = 0.003). In histology there are also significantly different depletions between the groups investigated (cTnT: p = 0.002; cTnC: p = 0.003; cTnI: p < 0.001) taking into account the autolysis time. 相似文献