黄芪-丹参对动脉粥样硬化大鼠肠道菌群的影响

目的 研究黄芪-丹参对动脉粥样硬化（atherosclerosis，AS）大鼠肠道菌群的影响。方法 将大鼠随机分为空白组、模型组、辛伐他汀组（1 mg/kg）、黄芪-丹参组（0.75 g/kg），采用高脂饲料喂养联合腹腔注射维生素D3 8周的方法复制AS模型，同时灌胃给药。采用自动生化分析仪检测大鼠血清总胆固醇（total cholesterol, TC）、三酰甘油（Triacylglycerol, TG）、低密度脂蛋白胆固醇（low-density lipoprotein cholesterol, LDL-C）水平，采用酶联免疫吸附试验检测血清肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）、白细胞介素-6（interleukin-6,IL-6）、白细胞介素-1β（interleukin-1β，IL-1β）水平，光学显微镜下观察胸主动脉病理变化，采用生物信息分析方法观察大鼠结肠内容物肠道菌群变化。结果 与空白组比较，模型组大鼠血清TC、TG、LDL-C、TNF-α、IL-6、IL-1β水平明显升高（P<0.05），HDL-C水平明显降低（P<0.05），胸主动脉血管内皮损伤严重，可见明显蓝色钙状斑块，结肠内容物肠道菌群Berger-Parker、Simpson指数明显降低（P<0.05），放线菌门（Actinobacteria）、乳杆菌属（Lactobacillus）、双歧杆菌属（Bifidobacterium）和杜氏杆菌属（Dubosiella）群落丰度明显降低（P<0.05），变形菌门（Proteobacteria）、疣微菌门（Verrucomicrobia）以及布劳特氏菌属（Blautia）、unclassified_f_Ruminococcaceae和Lachnospiraceae_NK4A136_group群落丰度明显升高（P<0.05）。与模型组比较，黄芪-丹参组大鼠血清血脂和炎症因子水平明显改善（P<0.05），胸主动脉血管内皮无明显损伤及增厚，大致恢复正常，结肠内容物肠道菌群Berger-Parker、Simpson指数明显升高（P<0.05），放线菌门、乳杆菌属、双歧杆菌属和杜氏杆菌属群落丰度明显升高（P<0.05），变形菌门、疣微菌门以及布劳特氏菌属、unclassified_f_Ruminococcaceae和Lachnospiraceae_NK4A136_group群落丰度明显降低（P<0.05）。〖JP〗结论 黄芪-丹参治疗AS的作用机制可能是通过调控肠道菌群改善血脂代谢和抑制炎症水平实现的。     

"堰塞湖"型社区治安管理模式探析 ——以北京市崔各庄东辛店村为例

基层治,则天下安。在新型城镇化纵深推进大背景下,对流动人口住处的疏解整治成为解决"大城市病"的必要手段,但实践中拆迁整治引发了"堰塞湖效应","堰塞湖效应"使得流动人口流入地社区演变成"堰塞湖"型社区。对此类社区的治安管理应革新以往防范式治安管理模式,有针对性地构建社区治安问题"审视→分析→反应→评估"的治安管理模式,根据"堰塞湖"型社区治安问题产生的原因及管理困境,形成一套从宏观到微观的逻辑严谨、运行有序的治安管理体系。具体可从树立"善治"和"共治"治安管理理念、促进流动人口社区融合和社区治安资源整合等方面入手解决"堰塞湖"型社区治安问题,以维护社区安全稳定。     

大国战略竞争与美国对华技术政策变迁

世界政治领导国的对外技术政策很大程度上源于应对大国战略竞争的需要。当美国面临直接、迫切的大国战略竞争压力时,更愿意通过放宽技术进口和出口限制来争取合作者、应对竞争者,即"利用强者打败更强者"。自20世纪70年代以来,美国对华技术政策经历了从逐步放松再到加强限制这一过程。苏联的安全竞争压力迫使美国在加强对苏技术出口限制的同时,放宽对华技术出口限制。日本的经济竞争压力促使美国在加强对日技术进口限制的同时,放宽对华技术进口限制。应对直接、迫切的大国战略竞争压力,会促使世界政治的领导国更重视当期利益,同时也为潜在竞争者的成长提供机会。而当苏联和日本对美国构成的大国战略竞争压力逐渐褪去时,美国对华技术政策再度面临调整压力,以致于今为甚,通过发起对华贸易战,打压中国高新技术产业,全面收紧了对华高技术进出口限制。美国的技术竞争将是今后很长时间中国技术进步难以绕过的阻碍。     

Human Services Providers’ Perspectives on Refugee Resettlement in the United States before and after the 2016 Presidential Election

Abstract

The United States has historically accepted and resettled refugees by opening its doors to those fleeing violence, armed conflict, or persecution around the world. However, the degree of receptivity toward refugee resettlement has vacillated over time. This study examines the challenges and opportunities that Refugee Resettlement Agencies (RRAs) experienced prior to and after the 2016?U.S. Presidential election. The findings presented in this paper, based on focus groups with the RRA staff, revealed that there is a greater need for understanding the refugee resettlement process and how changing immigration policies impact state-federal funding.     

大国博弈、双层均势的亚洲时刻--俄罗斯智库对中美经贸摩擦的认知与政策立场

俄罗斯智库对中美经贸摩擦有着独特的认知和期待,并与克里姆林宫的官方立场互为表里。总体上,俄方智库的观点是,在经贸摩擦的背后,是中美两国对军事、政治、科技、地区和全球领导权的竞争;两国的国内议程和对外政策,将因此受到深远影响并产生溢出效应--在亚洲区域内形成两极结构。即使两国会因国内和国际政治因素,在经贸问题上达成妥协,但中方不会放弃获得世界科技领导者的雄心,美方也不会打消遏制中国发展动能的战略意图。俄罗斯应与中国继续保持经济与军事合作,避免与美国和西方关系的继续恶化,并在亚太地区推动"大欧亚伙伴关系"倡议。俄罗斯政策分析界基于自身利益的演绎,将中美经贸摩擦定性为大国博弈,相应的政策建议反映出俄罗斯以在全球和亚洲分别制衡美中为目标的双层均势策略。俄罗斯将在有亚洲其他国家参与的情景下扮演战略平衡手角色,借中美全面对抗之势,在中美俄三边关系之外扭转不利的外部发展环境。俄罗斯对亚太国际局势的盘活作用,将催生双边和三边竞合新模式的建立。     

世界大变局与中美日三国战略选择

在世界大变局中,战后国际格局重大变化的主要标志是“世界老二”易位。苏联、日本皆不例外;21世纪以来欧盟也由盛转衰。未来国际格局可能有三种前景:1.中美两极对抗体制;2.中美竞争合作的“两极多元体制”;3.世界各大力量多元并存,构建多元一体的人类命运共同体。这要看世界潮流是走向和平多边主义还是暴力多边主义。中国实现伟大复兴后的战略选择是“济弱扶倾”,为世界可持续发展与可持续安全做贡献。日本面临的战略选择是:继续在《日本国宪法》下走和平发展道路,还是修改宪法,成为“能战国家”的一员,加入暴力强权的多边主义?坚持开放的地区主义与国际协调,还是搞排他经济集团,远交近攻,以中国为竞争对手?利用中美对立从中渔利,还是促进中美协调而避免在中美之间“选边站”?妥善处理中日两国围绕钓鱼岛归属认知争议和台湾问题,还是重走历史老路?囿于冷战思维和传统权力政治的现实主义决策逻辑,同中国搞战略对抗,还是树立共同、综合、合作、可持续安全的新安全观,与中国加强合作?这些战略选择将关乎未来30年的中日关系。     

关于越战期间美国老挝政策的国外成果研究综述

冷战初期，老挝本不是美国东南亚政策的重点问题，但随着越南战争的爆发，美国对老挝的重视程度逐步加深，直至派出地面部队进行干涉。这一问题值得深思。国外针对该领域的研究已硕果累累，但国内的相关研究才刚刚起步。对国外相关研究成果的整理和推介，应有助于推动国内学者在该领域的研究取得更新突破。     

Women,Science and Culture: Science in the Nineteenth-century Periodical

The Victorian periodical press offers unique insights into many diverse areas of nineteenth-century experience, and the complex relations between gender, science and culture in particular, yet it has been consistently marginalized as a primary resource in academic study. The Science in the Nineteenth-century Periodical (SciPer) project at the universities of Sheffield and Leeds is creating a new point of access to a wide range of non-specialist periodicals across the century by means of a fully searchable electronic index. By detailing the entire contents of each journal, and not just those articles that have a clear scientific relevance, it becomes clear that science formed a fundamental and integral part of nineteenth-century culture. The electronic index, moreover, will include hypertext cross-reference links that will allow the user to identify a dialogic pattern of encounters between ostensibly diverse articles, rather than only to browse in a simple chronological mode. By adopting this innovative approach, the SciPer database will reveal the manifold intertextual relations between the fictional works of women writers like Elizabeth Gaskell and the scientific articles that often appeared in the pages of the same magazines, and will show that writers of both sexes and across several different genres actively engaged in vibrant interdisciplinary debates concerning scientific issues in a forum provided by the periodical. Although the SciPer database itself is not specifically focused on issues of gender, the index will include several periodicals aimed explicitly at a female readership and, by providing access to titles still rarely utilized in modern scholarship, it will offer further insights into the important contemporary debates about women and science, as well as the more subtle ways, in which gendered imagery was employed within scientific discourse. This article details some critical findings from Punch , The English Womans Domestic Magazine , Cornhill Magazine and the Review of Reviews .     

Fund Accounting from the Italian Early Tradition to the U.S. GAAP for Governments

Surprising correspondences emerge from the parallel investigation of fund accounting practices in Italian entities until the late nineteenth century and in the contemporary U.S. public sector. The analysis attempts to interpret similarities and differences in light of dissimilar environmental features, and wonders if the Italian tradition could have some explanatory capability on the U.S. present standards. The “fund” concept and its use are strictly similar; they are founded on information needs for governance and internal control. Contemporary requirements for democracy and transparency, and opportunities coming from modern ICT tools bring U.S. organizations to be accountable to the citizenry.     

Fiscal Austerity and Rental Housing Policy in the United States and United Kingdom, 2010–2016

After the 2008 global financial crisis, both the United States and the United Kingdom introduced austerity policies targeted at particular elements of their national budgets. The purpose of this article is to compare the nature of this retrenchment; the similarities and differences in how it was implemented; and its initial impacts on one of the expenditure areas particularly affected: affordable rental housing programs and housing support for low-income households. Using a wide range of data sources, we find evidence of political and fiscal policy analogies in the timing and forms of the initial policy choices and how these were modified in the face of economic and political pressures. There are considerable similarities both in the instruments used to reduce housing expenditures and in the early impacts on support mechanisms and recipients. However, we find different histories and trajectories of support between the two countries that suggest that the longer term differences in outcomes may be more important.