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| CAR在病毒性心肌炎和扩张型心肌病心肌中的表达 | |
| 作者姓名： | Xu HF Chen JL Da XP Wu KR Liu GQ Zhao ZQ Han XH |
| 作者单位： | 1. 南通大学,医学院法医学教研室,江苏,南通,226001;复旦大学,上海医学院法医学系,上海,200222 2. 启东市公安局,刑警大队,江苏,启东,226200 3. 南通大学,医学院法医学教研室,江苏,南通,226001 4. 复旦大学,上海医学院法医学系,上海,200222 |
| 摘 要： | 目的探讨病毒性心肌炎(viral myocarditis,VMC)和扩张型心肌病(dilated cardiomyopathy,DCM)的发病机制及相互关系,从而提高心源性猝死法医学鉴定的可靠性和准确性。方法对VMC组22例、DCM组20例和对照组16例的心肌组织中柯萨奇-腺病毒受体(coxsackie-adenovirus receptor,CAR)的表达进行改良的免疫组织化学研究。结果 VMC组和DCM组心肌组织细胞膜呈现深棕黄色阳性颗粒,有较高水平的CAR表达,与对照组比较,差异有统计学意义(P<0.05),对照组染色阴性。结论 VMC和DCM组心肌中CAR的高表达,提示VMC和DCM的发病机制可能与病毒感染有关,病毒感染并破坏心肌细胞导致心肌细胞坏死,心功能受损,使VMC进展为DCM。 |
| 关 键 词： | 法医病理学 猝死 心脏 心肌病 扩张型 病毒性心肌炎 柯萨奇-腺病毒受体 |
Expression of CAR in myocardial of viral myocarditis and dilated cardiomyopathy |
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| Xu HF,Chen JL,Da XP,Wu KR,Liu GQ,Zhao ZQ,Han XH.Expression of CAR in myocardial of viral myocarditis and dilated cardiomyopathy[J].Journal of Forensic Medicine,2010,26(5):328-331. | |
| Authors: | Xu Hong-Fei Chen Jian-Lei Da Xu-Ping Wu Ke-Rong Liu Guo-Qing Zhao Zi-Qin Han Xin-Hua |
| Institution: | XU Hong-fei1,2,CHEN Jian-lei3,DA Xu-ping1,WU Ke-rong1,LIU Guo-qing1,ZHAO Zi-qin2,HAN Xin-hua1(1.Department of Forensic Medicine,Medical College of Nantong University,Nantong 226001,China,2.Department of Forensic Medicine,Shanghai Medical College,Fudan University,Shanghai 200222,3.Criminal Police Brigade of Qidong Public Security Bureau,Qidong 226200,China) |
| Abstract: | Objective In order to improve accuracy and reliability of forensic diagnosis of sudden cardiac death,pathogenesis and relationship between the viral myocarditis(VMC) and dilated cardiomyopathy(DCM) were investigated.Methods Improved immunohistochemical technique was used to detect the expression of the CAR in myocardium samples,including 22 deceased with VMC,20 deceased with DCM and 16 control deceased.Results The brown staining on the cell membrane of myocardium showed positive result.There was a prominent... |
| Keywords: | forensic pathology death sudden cardiac cardiomyopathy dilated viral myocarditis coxsackieadenovirus receptor |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |