中西医结合治疗脑缺血的血管保护机制

缺血性脑卒中已经逐渐成为导致残疾乃至死亡的首要因素,寻找新的治疗方法和有效的干预策略是神经科学研究领域的热点和难点.血管保护属于广义上的神经保护范畴,但从严格意义上讲两者之间还是稍有差别的.广义的血管保护包括抗血栓治疗、抗高血压治疗以及能够直接从血管内皮干预中获益的措施,而狭义的血管保护是指他汀类药物、血管紧张素转换酶抑制剂及血管紧张素受体拮抗剂.中医活血化瘀、补肾填精、祛风通络以及温阳利水法与血管保护之间可能存在着某种联系,确切的作用机制尚有待于进一步的研究证实.

Vascular Protection Mechanism of Integrated Traditional Chinese and Western Medicine in Treating Ischemic Stroke

Nowadays,ischemic stroke gradually become a major cause of morbidity and mortality.Furthermore,the hotspot and difficulty on neuroscience research is looking for new and effective intervention strategy.In general,vascular protection belongs to neuroprotection in spite of slight distinction in entity.In practical terms,any strategy proven to reduce the incidence of fatal and nonfatal vascular events could be said to be "vascular protection",including antithrombotic and antihypertensive therapies,and agents with direct beneficial effects on vascular endothelium.Moreover,considering that vascular events include myocardial infarction,stroke and claudication,so most prominent agents in this realm include the statins,angiotensin converting enzyme inhibitors(ACEI),and angiotensin receptor blockers(ARBs).In traditional Chinese medicine,some therapies,such as activating blood circulation to dissipate blood stasis,invigorating the kidney and replenishing the essence,dispelling wind and removing obstruction in the meridians as well as warming yang to promote diuresis,are possibly related to vascular protection,nevertheless,positive effect should be waiting for more evidence in the near future.