| 侧脑室注射IL-6对大鼠脑电活动的影响及柴胡皂苷a的干预作用 |
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| 作者姓名： | 谢炜 鲍勇 李长征 康萍 |
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| 作者单位： | 南方医科大学南方医院中医内科 广东广州510515 |
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| 基金项目： | 广东省自然科学基金项目（06024429）;广东省中医药管理局科研项目（1060133） |
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| 摘 要： | 目的:研究IL-6对大鼠脑电活动的影响,以及柴胡皂苷a(saikosaponin a,SSa)的干预作用。方法:采用侧脑室注射IL-6观察24 h内对大鼠脑电活动的影响,通过对脑电图描记,计算尖波个数以及高频(100 Hz)脑电的功率和波幅的变化,并研究SSa的干预作用。结果:IL-6可诱发大鼠脑电痫性活动,使大鼠高频(100 Hz)脑电波的功率和波幅的增大(P<0.05);SSa高剂量组2,4,8,12 h时能显著抑制大鼠脑电中尖波个数(P<0.05),抑制脑电的功率(4,8,12 h时)和波幅(1,4,8,12 h时)的增大(P<0.05)。结论:SSa高剂量可以抑制IL-6诱发大鼠脑电的痫性放电。
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| 关 键 词： | 癫痫 柴胡皂苷a IL-6 脑电图 |
| 修稿时间： | 2007/4/2 0:00:00 |
The Effect of IL-6 Injected to Lateral Ventricle on Rat EEG and the Role of Saikosaponin a |
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| Authors: | XIE Wei BAO Yong LI Chang-zheng KANG Ping |
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| Institution: | Department of Traditional Chinese Medicine, Nan-fang Hospital, Southern Medical University, Guangdong Guangzhou 510515, China |
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| Abstract: | Objective: To study the effect of IL-6 injected to lateral ventricle on rats EEG and the role of Saikosaponin a(SSa).Methods: The rats EEG were examined within 24 h after the injection of IL-6 into lateral ventricle,and counted the sharp wave,computed the power and amplitude of the high-frequency(100 Hz)wave.Results: The sharp wave were induced by IL-6,and the power and amplitude of the high-frequency(100 Hz)wave were increased(P<0.05);the high dose of SSa can significantly reduced the piece of sharp wave(2,4,8,12 h,P<0.05),and it can decreased the power(4,8,12 h) and amplitude(1,4,8,12 h) of the high-frequency(100 Hz) wave(P<0.05).Conclusion: The high dose of SSa can inhibit the epileptic EEG of rats induced by IL-6. |
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| Keywords: | Epilepsy Saikosaponin a IL-6 EEG |
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