保肾片治疗慢性肾衰竭气阴两虚兼湿浊证临床观察

目的：观察保肾片对慢性肾衰竭(CRF)气阴两虚兼湿浊证的疗效。方法：采用随机、双盲双模拟、对照方法，治疗组22例患服用保肾片加空白模拟片，对照组24例患服用肾康宁加空白模拟片。观察两组患治疗前后中医证候积分值、血肌酐(SCr)、内生肌酐清除率(CCR)变化情况。结果：治疗组总有效率为86．4％，对照组总有效率为70．0％。两组患中医证候积分值、SCr均显下降(P＜0．05或P＜0.01)，CCR明显升高(P＜0．05或P＜0．01);且治疗组较之于对照组，上述指标明显改善(P＜0．05或P＜0．01)。结论：保肾片可明显改善CRF气阴两虚兼湿浊证的临床表现，降低SCr水平，提高CCR。

Clinical Observation on Treatment of Chronic Renal Failure(Deficiency of Both Qi and Yin,Damp Pathogen Syndrome) with Baoshen Tablet

Objective:To observe the curative efficacy of Baoshen tablet (BST) in treating chronic renal failure(CRF) with deficiency of both Qi and Yin and damp pathogen syndrome (DQYDS).Method: The randomized, double blind,double imitated and controlled trial was used.22 cases in treatment group were treated with BST and imitated tablet,and 24 cases in control group with Shenkangning tablet and imitated tablet.ThechangesofthecumulativescoresoftraditionalChinesemedicine(TCM )syndrome ,thelevelsofserumcreatinine (SCr)andcreatinineclearancerate(CCR)beforeandaftertreatmentinbothgroupswereobserved .Result:The totaleffectiveratewas 86 .4 %intreatmentgroup ,but 70 .0 %incontrolgroup .ThescoresofTCMsyndrome andthelevelsofSCrwerebothsignificantlydecreased (P <0 .0 5orP <0 .0 1)intwogroups ,CCRwassignifi cantlyincreased ,meanwhiletheindexesintreatmentgroupweremoresignificantlyimprovedthanthoseincon trolgroup(P <0 .0 5orP <0 .0 1) .Conclusion :BSTcanmarkedlyimprovetheclinicalmanifestationsofCRF withDQYDS ,decreasethelevelsofSCr ,butincreaseCCR .