痛经合剂治疗原发性痛经机制的实验研究

目的:探讨痛经合剂治疗原发性痛经的药理学机制。方法:观察痛经合剂对正常雌性大鼠体外子宫平滑肌和催产素所致的子宫平滑肌收缩的作用,及其对雌性小鼠痛经模型和醋酸所致小鼠疼痛和对小鼠的催眠作用。结果:痛经合剂能显著抑制正常大鼠体外子宫平滑肌和催产素所致的体外子宫平滑肌的收缩,明显减少雌性小鼠痛经模型和醋酸所致小鼠扭体反应次数,显著增加戊巴比妥阈下发生睡眠的小鼠个数。结论:痛经合剂具有的解痉、镇痛、镇静作用,是其治疗原发性痛经的药理学依据。

Experimental Study on Treating Primary Dysmenorrhea with Tongjing Mixtures

Objective:To testify pharmacological effects of Chinese medicine Tongjing mixtures(TJM) in treating primary dysmenorrheal(PD).Method: To observe the autonomic contraction activities of free rat uterus both in normal status and in those induced by oxytocin and the action of TJM to menorrhalgin mice induced by oxytocin or by acetic acid.Meanwhile study the action of TJM to mice given sodium pentobartital.Result:TJM could strongly inhibit the autonomic contraction activities of free rat uterus both in normal status and in those induced by oxytocin,which is the main functional mechanism of TJM.It could significantly decrease the torsion times of menorrhalgia mice induced by oxytocin or by acetic acid.It could markedly increase the quantities of mice which fell asleep given sodium pentobartital.Conclusion: TJM can inhibit automatic contraction of uterus muscles,which may be pharmacological foundations of its medical effectiveness.