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禽分枝杆菌副结核亚种保护性抗原的研究进展
引用本文:徐凤宇,姜秀云,么乃全,钱爱东.禽分枝杆菌副结核亚种保护性抗原的研究进展[J].中国兽医科学,2011(7).
作者姓名:徐凤宇  姜秀云  么乃全  钱爱东
作者单位:吉林农业大学动物科技学院;吉林农业大学动物生产及产品质量安全教育部重点实验室;吉林农业大学生命科学学院;
基金项目:国家科技支撑计划项目(2007BAD55B05); 国家自然科学基金项目(30471285); 吉林省教育厅项目(2011)
摘    要:为了给副结核病新型疫苗研究中抗原的选择提供参考,综述了超氧化物歧化酶和巯基过氧化物酶等酶类、热休克蛋白、抗原85复合物及其他一些抗原在激发实验动物细胞和体液免疫中所发挥的作用,同时总结了在实际应用中可供借鉴的经验。

关 键 词:禽分枝杆菌副结核亚种  保护性抗原    热休克蛋白  

Research advances in protective antigens of Mycobacterium avium subsp. paratuberculosis
XU Feng-yu a,b,JIANG Xiu-yun c,YAO Nai-quan a,QIAN Ai-dong a,b.Research advances in protective antigens of Mycobacterium avium subsp. paratuberculosis[J].Veterinary Science in China,2011(7).
Authors:XU Feng-yu a  b  JIANG Xiu-yun c  YAO Nai-quan a  QIAN Ai-dong a  b
Institution:XU Feng-yu a,b,JIANG Xiu-yun c,YAO Nai-quan a,QIAN Ai-dong a,b(a.College of Animal Science and Technology,b.Key Laboratory of Animal Production,Product Quality and Security of the Ministry of Education,c.College of Life Sciences,Jilin Agricultural University,Changchun 130118,China)
Abstract:In order to provide references for the choice of antigen in development of new vaccines against paratuberculosis,the paper reviews the functions of some enzymes,such as superoxide dismutase(SOD) and thiol peroxidase,heat shock proteins,antigen85 complex and the other antigens during the sti-mulation of cellular and humoral immunity in laboratory animals,and some available experience in application is also summarized.
Keywords:Mycobacterium avium subsp  paratuberculosis  protective antigen  enzyme  heat shock proteins  
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