| 早期心肌缺血猝死心肌Ⅰ型胶原的表达 |
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| 作者姓名： | Gao SH Liu C Tan QF Huang FJ |
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| 作者单位： | 1. 四川大学华西基础医学与法医学院,四川成都,610041
2. 四川大学华西医院感染性疾病中心,四川成都,610041 |
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| 摘 要： | 目的探讨Ⅰ型胶原蛋白在心肌早期缺血死后诊断中的法医学价值。方法将收集的案例心肌蜡块分为3组：正常对照组、早期心肌缺血组、心肌梗死组,用免疫组织化学技术（S-P法）,观察猝死心肌内Ⅰ型胶原的表达情况,对其结果进行半定量分析。结果早期心肌缺血组和心肌梗死组心肌细胞质以及细胞核染色阳性,且早期心肌缺血组与心肌梗死组表达强度相近,说明早期心肌缺血组在胶原网结构方面已经发生与心肌梗死相同的改变。结论Ⅰ型胶原可以作为早期心肌缺血的一个诊断指标。
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| 关 键 词： | 法医病理学 免疫组织化学 心脏性猝死 Ⅰ型胶原 |
Expression of myocardial collagen I in early acute myocardial ischemic of human |
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| Gao SH,Liu C,Tan QF,Huang FJ.Expression of myocardial collagen I in early acute myocardial ischemic of human[J].Journal of Forensic Medicine,2008,24(3):175-177,241. |
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| Authors: | Gao Shu-Hong Liu Cong Tan Qiu-Feng Huang Fei-Jun |
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| Institution: | West China School of Preclinical and Forensic Medicine, Sichuan University Chendu 610041, China. |
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| Abstract: | OBJECTIVE: To estimate the significance of myocardial collagen I in the early acute myocardial ischemia of human. METHODS: The myocardial paraffin block had normal group, early myocardial ischemia group and myocardial infarction group. The myocardial collagen I was observed with immunohistochemical staining and analyzed by half-quantity. RESULTS: The similar expression of collagen I was observed in the cytoplasm and nucleolus in two groups. CONCLUSION: The collagen I appeared in the myocardium of early acute myocardial ischemia of human. It may be an important index for postmortem diagnosis of the early acute myocardial ischemia. |
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| Keywords: | forensic pathology immunohistochemical staining sudden cardiac death collagen Ⅰ |
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