6-羟多巴胺对小鼠体重及其小肠黏膜结构的影响

采用组织学和图像分析技术,研究了小鼠经腹腔注射交感神经损毁剂6-羟多巴胺后小鼠体重和小肠绒毛长度、V/C比值、绒毛宽度以及黏膜厚度的变化。结果表明,注射6-羟多巴胺组与对照组小鼠相比,体重下降(约3.4%);小肠绒毛变短(5.6%~19.4%),V/C比值减少(0.88%~24.1%),绒毛变窄(8.8%~24.7%)、黏膜厚度变薄(4.4%~16.9%),其中空肠的绒毛长度和黏膜厚度减少较明显,而十二指肠和回肠的V/C比值和绒毛宽度减少较明显。提示交感神经的活动可影响小肠的黏膜结构,从而影响肠道的消化吸收功能。

Effects of 6-OHDA on the body weight and structure of small intestinal mucosa in mice

The changes of body weight,intestinal villus length,V/C value,villus width and mucous thickness in mice,which were injected intraperitoneally with the sympathetic denervation dose of 6-OHDA,were investigated.The results showed that the mice's body weigh decreased by about 3.4%after 6-OHDA treatment.Compared with the control group,the intestinal villus length,V/C value,villus width and mucous thickness in the 6-OHDA-treated group were significantly reduced by 5.6%-19.4%,0.88%-24.1%,8.8%-24.7% and 4.4%-16.9%,respectively.Among them,the reductions were very significant in the villus length and mucous thickness of jejunum,and the V/C values and villus lengths of both ileum and duodenum.The results suggest that the sympathetic nerves play a role in modulation of structures and functions of the intestinal mucosa.