肾脏组织肌红蛋白检测在法医病理诊断中的应用价值

应用免疫组化方法,对49例被尸检的人肾组织进行肌红蛋白检测,其中生前有广泛软组织损伤的损伤组22例,冠心病猝死组15例,并用12例无上述病史的人肾脏组织作对照.结果显示损伤组有8例(8/22)远曲小管及集合管管腔内管型呈肌红蛋白阳性或强阳性;冠心病猝死组有3例皮质肾小管内管型呈阳性;对照组均为阴性.说明肾肌红蛋白检测对挤压综合征(crushsyndrome,CS)死后诊断有重要价值.

THE VALUATION OF DETECTING MYOGLOBINOF KIDNEY IN FORENSIC PATHOLOGICAL DIAGNOSIS

By immunohistochemistry staining,myoglobin detection was made in the k idney block of 49cases,22of which with extensive injury in muscle and soft tissue before their death a s injury group,15of which with sudden death from coronary artery disease(CAD)as CAD group,and 12of which free from any of the above histories as control.The study showed that in the injury group,the positive rate of myoglobin masses was in the cavities of renal and collecting tubules of 8cases(8/22).In the CAD group,there are few myoglobin masses in the cortical renal tubules in 3cases(3/15),whereas the all detection in the con trol group were negative.Myoglobin detection of kidney may play an im-portant role in forensic pathologic al diagnosis of crush syndrome (CS).