| 中国汉族群体人类补体C8A多态性 |
| |
| 引用本文： | 张林,裴黎,李荣华,陈国弟,吴梅筠.中国汉族群体人类补体C8A多态性[J].中国法医学杂志,2000,15(2):72-74. |
| |
| 作者姓名： | 张林 裴黎 李荣华 陈国弟 吴梅筠 |
| |
| 作者单位： | 1. 华西医科大学法医物证教研室,成都,610041
2. 公安部物证鉴定中心,北京,100038 |
| |
| 摘 要： | 采用免疫沉淀、SDS-聚丙烯酰胺凝胶电泳 (SDS- PAGE)、被动转印及酶免分析 ,研究了人类补体 C8A等位基因频率在成都地区汉族群体中的分布。 12 1份样本被分为 3种常见型 ,即 C8A- A、C8A- B及 C8A- AB,由两个等位共显性基因 C8A * A及 C8A* B控制 ;同时发现了 2个稀有亚型 ,即 A3亚型及新发现的 Ax亚型。等位基因频率为 C8A* A=0 .5 0 83,C8A* B=0 .4835 ,C8A*稀有型 =0 ,0 0 83。说明 C8A多态性在中国群体中具有良好的分布 ,个人识别率(DP)达到 6 1.14% ,可用于法医学个人识别及亲子鉴定
|
| 关 键 词： | 补体第八成分(C8A) 多态性 亚型 |
| 修稿时间： | 1999年10月1日 |
Genetic polymorphism of human complement C8A in the Chinese Han population and a new allele |
| |
| ZHANG Lin,PEI Li,LI Ronghua,et al..Genetic polymorphism of human complement C8A in the Chinese Han population and a new allele[J].Chinese Journal of Forensic Medicine,2000,15(2):72-74. |
| |
| Authors: | ZHANG Lin PEI Li LI Ronghua |
| |
| Institution: | ZHANG Lin,PEI Li,LI Ronghua,et al./College of Forensic Medicine,West China University of Medical Sciences,Chengdu 610041 |
| |
| Abstract: | Genetic polymorphism of human C8A has been investigated by immunoprecipitation,and separation on sodium dodecylsulfate polyacrylasmide gel electrophoresis (SDS-PAGE)under non-reducing conditions, followed by west-blotting with immunoassay.In 121 samples from unrelated individuals of Chinese Han population,three common phenotypes and two rare phenotypes controlled by two common alleles, C8A*A and C8A*B,and two rare alleles which were designated C8A*A3 and C8A*Ax for acidic variants were observed.The C8A*Ax is a new rare allele.The gene frequencies were:C8A*A 0.5083,C8A*B 0.4835,C8A*A3 and Ax 0.0083,respectively. |
| |
| Keywords: | Human complement C8 Polymorphism New allele |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
