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| 基质金属蛋白酶2在冠心病猝死心肌中的表达 | |
| 引用本文： | 吴薇,冯相平,陈新山. 基质金属蛋白酶2在冠心病猝死心肌中的表达[J]. 中国法医学杂志, 2009, 24(1): 1-4 |
| 作者姓名： | 吴薇 冯相平 陈新山 |
| 作者单位： | 1. 华中科技大学同济医学院法医学系,湖北,武汉,430030;北京世纪坛医院医务处,北京,100038 2. 华中科技大学同济医学院法医学系,湖北,武汉,430030;温州医学院法医学系,浙江,温州,325035 3. 华中科技大学同济医学院法医学系,湖北,武汉,430030 |
| 摘 要： | 目的探讨基质金属蛋白酶2（mmp2）在冠心病猝死（SCD）心肌细胞和间质中的表达与SCD的关系。方法选取本教研室2003年51例死亡鉴定病例，分为SCD组，患有冠心病但非SCD组（对照组1），无严重冠脉粥样硬化（As）病变和其它心血管疾病组（对照组2），无严重As病变但有其它心脏病组（对照组3）。采用免疫组化SABC法染色及图像分析技术，检测mmp2在各组心肌细胞和间质内表达的阳性率（R值）和平均灰度值（H值），并比较各组间的差异。结果SCD组与3个对照组之间心肌细胞内romp2H值的差异均有显著性意义；SCD组与对照组2和3之间心肌间质内mmp2H值的差异有显著性意义；镜下各组心肌间质及心肌细胞内表达的阳性率差别明显。结论心肌间质及心肌细胞内mmp2同相表达增高与SCD的发生有密切关系，联合检测心肌和间质mmp2的表达对诊断SCD有重要意义。 |
| 关 键 词： | 法医病理学 冠心病猝死 基质金属蛋白酶2 心肌 免疫组织化学 |
Significance of matrix metalloproteinas-2 expression in myocardia and interstitial in the case of sudden coronary death |
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| WU Wei,FENG Xiangping,CHEN Xinshan. Significance of matrix metalloproteinas-2 expression in myocardia and interstitial in the case of sudden coronary death[J]. Chinese Journal of Forensic Medicine, 2009, 24(1): 1-4 | |
| Authors: | WU Wei FENG Xiangping CHEN Xinshan |
| Affiliation: | WU Wei1;2;FENG Xiangping1;3;CHEN Xinshan1/1.Faculty of Forensic Medicine;Tongji Medical College of Huazhong University of Science and Technology;Wuhan 430030;China;2.Administration Department;Beijing Shijitan Hospital;Beijing 100038;3.Department of Forensic Medicine;Wenzhou Medical College;Zhejiang Wenzhou 325035;China |
| Abstract: | Objective To investigate matrix metalloproteinas-2(mmp2) expression in myocardia and interstitial in the cases of sudden coronary death(SCD) and its relationship with SCD.Methods Heart samples of 51 cases,which autopsied in our department in 2003,were selected and classified as 4 groups of SCD and 3 control groups.Control group-1 was coronary heart disease(CHD) but not SCD,control group-2 had no serious atherosclerosis(As) or any other cardiovascular disease,control group-3 had no serious As but had other h... |
| Keywords: | forensic pathology sudden coronary death matrix metalloproteinas-2 myocardium immunohistochemistry |
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