| 15个STR在单亲亲子鉴定中的排除分析 |
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| 引用本文： | 吕德坚,刘秋玲,陆惠玲,陈丽娴.15个STR在单亲亲子鉴定中的排除分析[J].中国法医学杂志,2003,18(6):332-334. |
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| 作者姓名： | 吕德坚 刘秋玲 陆惠玲 陈丽娴 |
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| 作者单位： | 中山大学中山医学院法医物证教研室,广东,广州,510089 |
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| 摘 要： | 目的评估15个短串联重复(DODIS)基因座和Penta D、Penta E)在单亲亲子鉴定中的亲权排除率。方法 以644个随机个体构成207046个假想的家系,然后统计不排除或只有一个基因座排除亲权关系的例数。结果有27个假想家系15个STR均不排除亲权关系,排除率为0.999869。有384个假想家系只有一个基因座排除,占0.185％。结论用15个STR认定单亲案的亲权关系时要谨慎。出现单个基因座排除时要检测更多的遗传标记,以区分是否系突变。
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| 关 键 词： | 法医物证学 亲权排除率 STR突变 单亲 |
| 文章编号： | 1001-5728(2003)06-0332-03 |
| 修稿时间： | 2002年11月1日 |
Exclusion of 15 Short Tandem Repeat Markers in Duo Paternity Testing |
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| LU Dejian,LIU Qiuling,LU
Huiling,CHEN Lixian /.Exclusion of 15 Short Tandem Repeat Markers in Duo Paternity Testing[J].Chinese Journal of Forensic Medicine,2003,18(6):332-334. |
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| Authors: | LU Dejian LIU Qiuling LU
Huiling CHEN Lixian / |
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| Institution: | LU Dejian,LIU Qiuling,LU
Huiling,CHEN Lixian /Department of Forensic Serology,Sun Yat-sen Medical College,74,Zhong-shan Road II,Guangzhou 510089 |
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| Abstract: | Objective Estimate the paternity exclusion probability for 15 short tandem repeats (CODIS set plus Penta D and Penta E) in duo paternity tests. Methods 644 random individuals were paired to con-struct 207046 fictitious duo families. Cases of non-exclusion or with only one exclusionarylocus were count-ed. Results 27 cases could not be excluded by the 15 STR loci. The combined probability of exclusion was 0.999869. Number of cases showing only one exclusionary locus was 384 (0.185%). Conclusion To con-firm relationship in duo cases with only 15 STRs should be careful. Extensive genetic markers is needed to discriminate one locus exclusion or mutation. |
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| Keywords: | Forensic physical evidence Probability of exclusion STR mutation Duo |
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