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A DYS438 null allele observed in two generations of a large family |
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| Authors: | B. Glock E.M. Dauber E.M. Schwartz-Jungl |
| Affiliation: | a Division of Blood Group Serology, Medical University of Vienna, Waehringer Guertel 18-20/4I, A-1090 Vienna, Austria b Institute of Legal Medicine, Innsbruck Medical University, Müllerstrasse 44, A-6020 Innsbruck, Austria |
| Abstract: | Typing of Y-chromosomal STR loci using the AmpFISTR® Yfiler kit showed a DNA profile lacking the DYS438 allele in an Austrian Caucasoid brother pair.Buccal swabs were collected from additional males of two generations and different branches of the family. All family members investigated did not show a DYS438 allele in their Yfiler profile. Using the Powerplex® Y system an allele with dramatically reduced peak height was amplified. Subsequent sequencing of the DYS438 locus exhibited a transition upstream of the repetitive region. |
| Keywords: | Y chromosome STR DYS438 Null allele |
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