| 化痰降气胶囊治疗实验性慢性支气管炎病理观察 |
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| 作者姓名： | 马燕 张睿 周丽 |
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| 作者单位： | 安徽中医学院第一附属医院药学部 |
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| 基金项目： | 国家中医药管理局资助项目 |
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| 摘 要： | 目的:初步观察化痰降气胶囊对大鼠实验性慢性支气管炎的治疗作用.方法:实验分组为化痰降气胶囊高、中、低剂量组(0.140,0.070,0.035 g/ml),桂龙咳喘宁组(0.53 g/kg),假手术组,模型组,气管注射脂多糖复制大鼠慢性支气管炎模型,光镜下观察化痰降气胶囊给药组大鼠的病理组织学改变.结果:化痰降气胶囊给药组大鼠的病理组织学指标明显改善,可减轻纤毛上皮脱落,减少杯状细胞增生和炎细胞浸润等症状,高剂量组效果优于中、低剂量组.结论:化痰降气胶囊对实验性慢性支气管炎大鼠具有治疗作用.
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| 关 键 词： | 慢性支气管炎 化痰降气胶囊 病理 |
Huatan Jiangqi Capsule in Treating Experimental Chronic Bronchitis: A Histopathologic Study |
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| Authors: | MA Yan ZHANG Rui ZHOU Li |
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| Abstract: | Objective:To initially observe therapeutic effects of Huatan Jiangqi(HTJQ) Capsule in treating experimental chronic bronchitis in rats.Methods: Rats were randomized into high-,middle-and low-dosage of HTJQ Capsule groups(0.140,0.070,0.035 g/ml,respectively),Guilong Kechuan Ning(GLKCN) Capsule group and sham operation group.The rat model of chronic bronchitis was induced by injecting lipopolysaccharide.The histopathologic changes of rats in all groups were observed under light microscope.Results: The histopathologic conditions of rats in HTJQ Capsule groups were markedly improved.HTJQ Capsule could relieve the amotio of ciliated epithelium;decrease the accrementition of caliciform cells and the infiltrating of inflammatory cells.The effects of high-dosage of HTJQ Capsule were superior to those of middle-and low-dosage of HTJQ Capsule.Conclusion: HTJQ Capsule possesses therapeutic effects on experimental chronic bronchitis in rats. |
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| Keywords: | Chronic bronchitis Huatan Jiangqi Capsule Histopathology |
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