| 牛病毒性腹泻病毒生物型转化分子机制的研究进展 |
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| 引用本文： | 李慧昕,王君伟.牛病毒性腹泻病毒生物型转化分子机制的研究进展[J].中国兽医科学,2005,35(8):657-660. |
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| 作者姓名： | 李慧昕 王君伟 |
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| 作者单位： | 1. 中国农业科学院,哈尔滨兽医研究所,黑龙江,哈尔滨,150001
2. 东北农业大学,动物医学院,黑龙江,哈尔滨,150030 |
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| 摘 要： | 从病毒基因与宿主细胞基因的重组、病毒基因的复制与重排、病毒基因的重复复制和序列插入、病毒基因的缺失和点突变几个方面阐述了牛病毒性腹泻病毒(BVDV)由非致细胞病变型(NCP)向致细胞病变型(CP)转化的分子变异机制。总结了前人对NCP型向CP型BVDV转化研究的结果,归纳了5种生物型转化形式,揭示了BVDV具有高变异性。
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| 关 键 词： | 牛病毒性腹泻病毒 生物型 分子变异 |
| 文章编号： | 1000-6419(2005)08-0657-04 |
| 修稿时间： | 2005年5月24日 |
Research advance in molecular mechanism of biotype alteration of bovine viral diarrhea virus |
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| LI Hui-xin,WANG Jun-wei.Research advance in molecular mechanism of biotype alteration of bovine viral diarrhea virus[J].Veterinary Science in China,2005,35(8):657-660. |
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| Authors: | LI Hui-xin WANG Jun-wei |
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| Institution: | LI Hui-xin~ |
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| Abstract: | The molecular mechanism of bovine viral diarrhea virus biotype alteration from noncytopathogenic type to cytopathogenic type was reviewed on the aspects of recombination between the virus gene and host gene, duplication and rearrangement of the virus gene, reduplication and sequence insertion of the virus gene, deletion and point mutation of the virus gene. By comparing the mechanism from NCP BVDV to CP BVDV, 5 forms of biotype alteration were summarized on the basis of former researchers' (results). It suggested that BVDV was highly variable. |
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| Keywords: | bovine viral diarrhea virus biotype molecular alteration |
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