| Lutheran血型系统的分子遗传学基础 |
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| 引用本文： | 唐剑频,蒋丰慧,于晓军. Lutheran血型系统的分子遗传学基础[J]. 法律与医学杂志, 2009, 0(4) |
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| 作者姓名： | 唐剑频 蒋丰慧 于晓军 |
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| 作者单位： | 广东医学院东莞校区法医学教研室;广东医学院东莞校区门诊部;汕头大学医学院法医学教研室; |
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| 摘 要： | Lutheran血型系统含有18个抗原,LU1/LU2、LU18/LU19抗原位于LU/B-CAM糖蛋白上。LU/B-CAM糖蛋白的蛋白质部分由LU基因表达,LU基因位于19q13.2-13.3,含15个外显子、14个内含子。LU基因在转录时发生变位剪接,产生2.5、4.0kb前体mRNA。LU基因在镰状红细胞、卵巢癌和结肠上皮细胞癌呈高表达。LU/B-CAM糖蛋白是层粘素特异性受体。
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| 关 键 词： | Lutheran血型系统 LU基因 受体 变位剪接 |
Molecular Genetics of Lutheran Blood Group System |
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| Tang Jianpin. Molecular Genetics of Lutheran Blood Group System[J]. The Journal of Law & Medicine, 2009, 0(4) |
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| Authors: | Tang Jianpin |
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| Affiliation: | Tang Jianpin,Department of Forensic Medicine,Guangdong Medical College,Dongguan 523808,Jiang Fenghui,The Clinical of Guangdong Medical College,Yu Xiaojun,Medical College of Shantou University,Shantou 515041. |
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| Abstract: | Lutheran blood group system have 18 antigens,LU1/LU2 and LU18/ LU19 antigens are curried by LU/B-CAM glycoprotein. The open reading frame of LU gene is 15 exons and 14 introns on 19q13.2-13.3. Alternative splicing of intron 13 generates the 2.5 and 4.0 transcript spliceoforms encoding the long tail and the short tail LU polypeptides. LU gene high express in sickle red cells,ovarian cancer cells and epithelial colon carcinoma cells. LU/B-CAM glycoprotein are receptor of laminin. |
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| Keywords: | Lutheran blood group system LU gene Receptor Alternative splicing |
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