| 实验性脑挫伤后神经元和星形胶质细胞反应的时间性变化 |
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| 引用本文： | 周高举,秦启生.实验性脑挫伤后神经元和星形胶质细胞反应的时间性变化[J].中国法医学杂志,1998(1). |
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| 作者姓名： | 周高举 秦启生 |
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| 作者单位： | 武汉市中级人民法院法医室!430015，同济医科大学法医病理教研室!武汉，430030 |
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| 摘 要： | 运用免疫组化技术，以神经元特异性烯酸酶（NSE）和胶质纤维酸性蛋白（GFAP）作为标记物，观察大鼠实验性脑挫伤后不同存活时间中神经元和星形胶质细胞的数量变化。结果发现，伤后3h可见NSE和GFAP染色变化，且随着存活时间延长，脑皮质内挫伤处周围神经元逐步减少，而星形胶质细胞则逐渐增加，具有一定的时间规律性。为脑挫伤后早期存活时间的推断提供了新的方法。
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| 关 键 词： | 脑挫伤 免疫组织化学 神经元特异性烯醇酶（NSE） 胶质纤维酸性蛋白（GFAP） 损伤时间 |
A study of the relation between the survival time and neurons,astrocites after experimental brain contusion |
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| Zhou Gaoju. et al..A study of the relation between the survival time and neurons,astrocites after experimental brain contusion[J].Chinese Journal of Forensic Medicine,1998(1). |
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| Authors: | Zhou Gaoju |
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| Abstract: | In this study,the changes of NSE and GFAP in the forebrain of rats at various survival time(3h to 120h) after experimental brain contusion were detemined by quantitative immunohistochemistry. The results demonstrated that the variat ions of NSE and GFAP were detected at 3h, the levels of NSE were steadily decroasod and the levels of GFAP were regularly increased with increasing of the survival time. This method could be used for estimating the early survival time died from brain injury. |
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| Keywords: | Brain contusion Immunohistochemistry NSE GFAP Survival time |
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