| 甲基苯丙胺对大鼠认知和脑电图的影响 |
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| 引用本文： | 王峰,黄宏平,朱庆春,张环环,王邦安,汪萌芽.甲基苯丙胺对大鼠认知和脑电图的影响[J].中国法医学杂志,2011,26(4):288-290. |
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| 作者姓名： | 王峰 黄宏平 朱庆春 张环环 王邦安 汪萌芽 |
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| 作者单位： | 1. 皖南医学院医学三系法医毒理和毒化教研室,安徽芜湖,241000
2. 皖南医学院人文与管理系细胞电生理研究室,安徽芜湖,241000 |
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| 基金项目： | 安徽省教育厅基金资助项目(KJ2008B233); 第四批安徽省优秀青年科技基金资助项目(08040106817) |
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| 摘 要： | 目的研究甲基苯丙胺（methamphetamine,MA）对脑功能的影响机制,实验设计观察慢性反复使用MA是否同时对大鼠认知行为和脑电活动产生影响。方法 14只雄性SD大鼠（180～200g）随机分为生理盐水注射组（对照组）和MA注射组（实验组5mg/kg体重）每天一次腹腔注射。连续注射7d后进行被动避暗回避行为测试和脑电图检测。结果与对照组相比,实验组大鼠表现为被动避暗回避行为的潜伏期延长,脑电图频谱分析显示δ波相对功率值减小,β波相对功率值增大,差异有统计学意义（P〈0.05）。结论慢性反复使用MA对大鼠被动回避行为和脑电活动均有影响,说明MA滥用造成的认知行为改变与中枢神经系统电生理活性改变有关。
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| 关 键 词： | 法医毒理学 甲基苯丙胺 认知行为 脑功能 大鼠 |
The effect of methamphetamine administration on cognitive behavior and electroencephalogram in rat |
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| WANG Feng,HUANG Hongping,ZHU Qingchun,ZHANG Huanhuan,WANG Banan,WANG Mengya.The effect of methamphetamine administration on cognitive behavior and electroencephalogram in rat[J].Chinese Journal of Forensic Medicine,2011,26(4):288-290. |
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| Authors: | WANG Feng HUANG Hongping ZHU Qingchun ZHANG Huanhuan WANG Banan WANG Mengya |
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| Institution: | WANG Feng1,HUANG Hongping2,ZHU Qingchun2,ZHANG Huanhuan2,WANG Banan2,WANG Mengya2/1.Department of The Third Medicine,Wan Nan Medical College,Anhui Wuhu 241000,China,2.Department of Humanity and Management,Cell Electrophysiology Lab |
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| Abstract: | Objective Methamphetamine(MA) is an addictive psychostimulant.In order to investigate the mechanism of MA influence on brain function,it was observed to the effect of chronic repeated MA administration on both cognitive behavior and electroencephalogram(EEG) in rat.Methods Fourteen male SD rats(180~200g) were randomly divided into saline injection group(control group) and MA injection group(experiment group),5.0 mg/kg,intraperitoneal(i.p.),qd for 7 days.Passive avoidance behaviors of rats were observed with... |
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| Keywords: | forensic toxicology methamphetamine cognitive behavior brain function rat |
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